Vitamin A status, hospitalizations, and other outcomes in young children with sickle cell disease

Schall, Joan I.; Zemel, Babette S.; Kawchak, Deborah A.; Ohene‐Frempong, Kwaku; Stallings, Virginia A.

doi:10.1016/j.jpeds.2004.03.051

Cited by 41 publications

(42 citation statements)

References 38 publications

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“…BMI Z-scores were low, and there were higher rates of hospital admission of vitamin A-deficient patients than of those with normal levels. 122 Zinc deficiency in SCD occurs at levels suggesting chronic zinc depletion and appears to be associated with chronic haemolysis and hyperzincuria. 123 Growth retardation and hypogonadism were observed in zinc-depleted men, suggesting its contribution to impaired growth and sexual maturation in SCD.…”

Section: Micronutrient Deficiencymentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises evidence of nutritional status in children with SCD in relation to anthropometric status, disease severity, body composition, energy metabolism, micronutrient deficiency and endocrine dysfunction. Methods: A literature search was conducted on the Medline/PUBMED, SCOPUS, SciELO and LILACS databases to July 2007 using the keywords sickle cell combined with nutrition, anthropometry, growth, height and weight, body mass index, and specific named micronutrients. Results: Forty-six studies (26 cross-sectional and 20 longitudinal) were included in the final anthropometric analysis. Fourteen of the longitudinal studies were conducted in North America, the Caribbean or Europe, representing 78.8% (2086/2645) of patients. Most studies were observational with wide variations in sample size and selection of reference growth data, which limited comparability. There was a paucity of studies from Africa and the Arabian Peninsula, highlighting a large knowledge gap for low-resource settings. There was a consistent pattern of growth failure among affected children from all geographic areas, with good evidence linking growth failure to endocrine dysfunction, metabolic derangement and specific nutrient deficiencies. Conclusions: The monitoring of growth and nutritional status in children with SCD is an essential requirement for comprehensive care, facilitating early diagnosis of growth failure and nutritional intervention. Randomised controlled trials are necessary to assess the potential benefits of nutritional interventions in relation to growth, nutritional status and the pathophysiology of the disease.

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Section: Micronutrient Deficiencymentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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show abstract

“…Increased protein turnover adds an additional nutritional burden (29,32). Nutrient deficiencies based on biomarkers have been reported for vitamins B 6 (33,34), D (35), and E (36,37); retinol (38); and zinc (39 -41). In a 12-mo trial, zinc supplementation was shown to increase linear growth in children with SCD-SS (40).…”

Section: Growth Failure In Sickle Cell Diseasementioning

confidence: 99%

Effects of Delayed Pubertal Development, Nutritional Status, and Disease Severity on Longitudinal Patterns of Growth Failure in Children With Sickle Cell Disease

et al. 2007

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“…Em relação à vitamina A, Schall et al 9 verificaram que 66% das crianças apresentavam concentração de retinol sérico abaixo dos níveis considerados ótimos (30 µg/dL) e, destas, 17% encontravam-se na faixa de deficiência de vitamina A (< 20 µg/dL). Kawchak et al 13 observaram que a ingestão de vitamina A foi menor entre as crianças com idade ≥ 9 anos comparadas às crianças mais novas, enquanto Schall et al 9 não encontraram baixa ingestão de vitamina A através de um único recordatório de 24 horas.…”

Section: Resultsunclassified

“…Kawchak et al 13 observaram que a ingestão de vitamina A foi menor entre as crianças com idade ≥ 9 anos comparadas às crianças mais novas, enquanto Schall et al 9 não encontraram baixa ingestão de vitamina A através de um único recordatório de 24 horas.…”

Section: Resultsunclassified

“…Estudos apontam que estes pacientes apresentam baixa ingestão dietética de alguns micronutrientes, como o ácido fólico, nutriente importante no processo de formação de eritrócitos e de vitamina B 6 , 7 assim como a deficiência de zinco e vitamina A, que são micronutrientes essenciais para o crescimento e maturação sexual adequados. 8,9 Com intuito de abordar os aspectos nutricionais da anemia falciforme, o presente trabalho teve o objetivo de elaborar uma revisão sistemática sobre os conhecimentos disponíveis na literatura acerca das deficiências de micronutrientes na anemia falciforme em crianças e adolescentes portadores da doença.…”

Section: Introductionunclassified

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