Vitamin B6 and Cancer

Fortmeyer, H. P.

doi:10.1007/978-1-4612-4516-2_15

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Toxicity is recorded in animal experimentation when long‐term dietary Se levels as selenite or selenomethionine of 5 ppm or above were used 6,9 . This is in contradistinction to some trace elements and vitamins, where correcting deficiency reduces cancer risk, whereas increasing supplements several fold above RDI can lead to increasing rates of some cancers, as has been shown, for example, with pyridoxine 10 …”

Section: Introductionmentioning

confidence: 99%

Influence of selenised dairy proteins on biomarkers of colon cancer risk

McIntosh

2008

Nutrition & Dietetics

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Selenium is an essential trace element for mammals, and a component of at least 25 selenoproteins which incorporate the amino acid selenocysteine (Sec). These proteins include a number with oxidoreductase functions. An examination of the selenoproteins and their influence on carcinogenesis in an animal model may assist in determining their relevance in chemoprevention.Food sources offer a number of organic forms of selenium, with selenomethionine a common component, as in selenised yeasts. A selenium-rich dairy protein product has been developed (TaturaBioSe, Tatura Milk Industries, Tatura, Victoria) which could improve selenium status in populations considered marginal or deficient. It could also provide higher intakes (e.g. several fold above recommended dietary intake recommendations) of potential benefit as chemopreventive to those at greater risk of some selenium-responsive diseases, such as some sporadic colorectal cancers. Clinical studies are showing it to be a safe, palatable product for consumption in the form provided.Dairy protein selenium at 1 ppm in diet had a significant chemopreventive effect compared with control (0.05 ppm Se) in an azoxymethane model of colon cancer. Colon tumour incidence in rats was down by 29%, and tumour burden (colon tumours/rat) was halved, effects not observed when an equivalent Se concentration was provided as yeast selenium. When assessed by plasma Se concentration, this dairy protein form of selenium showed greater bioavailability (as assessed by plasma selenium) as well as efficacy in chemoprevention. Programmed cell death (apoptosis) was increased in colonic crypts and crypt height significantly diminished. The influence on early changes in carcinogenesis provides an insight into possible mechanism(s) of action. Histological and biochemical assays (e.g. monitoring oxidoreductase enzymes) could potentially provide early biomarkers with clinical relevance.

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Section: Introductionmentioning

confidence: 99%

Influence of selenised dairy proteins on biomarkers of colon cancer risk

McIntosh

2008

Nutrition & Dietetics

View full text Add to dashboard Cite

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Vitamin B6 and Cancer

Cited by 1 publication

References 13 publications

Influence of selenised dairy proteins on biomarkers of colon cancer risk

Influence of selenised dairy proteins on biomarkers of colon cancer risk

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