Vitamin B6 as an Antidote against the Rodenticide ‘Castrix’ (2-Chloro-4-methyl-6-dimethylaminopyrimidin)

Karlog, Ole; Knudsen, Erik S.

doi:10.1038/200790a0

Cited by 11 publications

(4 citation statements)

References 2 publications

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“…5 Pyridoxine-HCI, Onderlinge Pharmaceutische Groothandel, Utrecht, the Netherlands. 6 Phenobarbital, Onderlinge Pharmaceutische Groothandel, Utrecht, the Netherlands. They appeared to be caused by the alligator clips attaching the electrocardiogram leads.…”

Section: Resultsmentioning

confidence: 99%

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Crimidine (2‐chloro‐4‐(dimethylamino)‐6‐methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix®

Lumeij

Schotman

Vries

1983

Veterinary Quarterly

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Section: Resultsmentioning

confidence: 99%

“…The antidotal effect of vit B6 (6,7) and barbiturates (2) against the convulsive action of crimidine (2-chloro-4-(dimethylamino)-6-methylprimidine) have been described under experimental conditions. No clinical reports of succesfully treated cases of crimidine poisoning in dogs or cats are to be found in the literature.…”

Section: Introductionmentioning

confidence: 99%

Crimidine (2‐chloro‐4‐(dimethylamino)‐6‐methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix®

Lumeij

Schotman

Vries

1983

Veterinary Quarterly

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“…The seizures induced by the B6 antagonists have been well known to be completely suppressed by the administration of vitamin B6 (10,12,13). Both glutamic decarboxylase and GABA transaminase involving in GABA metabolism are vitamin B6 dependent enzymes, and the glutamic decarboxylase activity is particularly affected by vitamin B6 deficiency (6).…”

Section: Discussionmentioning

confidence: 99%

Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.

Matsuda

Kawamata

1976

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Pyrimidines and fused pyrimidines are heterocyclic aromatic compounds with a particular interest because they represent a large class of natural and synthetic compounds; many of which have biological and therapeutic applications [1,2]. Pyrimidine and fused pyrimidines are significant in agriculture chemicals; insecticides [3,4], rodenticide [5,6], fungicides [7,8], and herbicides [9,10]. Pharmaceutical's preparations are some of the biological activities of fused pyrimidines derivatives [11,12], e.g., anticancer [13,14], antimicrobial agents [15,16] and antibacterial [17].…”

Section: Introductionmentioning

confidence: 99%

Biological Activity of Fused Pyrimidine Derivatives on Vital Parameters of Male Albino Rats

Mahmoud

2022

Bulletin of Faculty of Science, Zagazig University

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The objective of the current study was to evaluate the toxicity of oral administration of three synthesized organic compounds by us; 2-Amino-3-benzyl-6-(benzylthio) pyrimidin-4(3H)-one (amino pyrimidine), 3-Benzyl-7-hydroxy-5-(4-hydroxyphenyl)-2-(phenylamino)pyrido [2,3-d]pyrimidin-4(3H)-one (pyridopyrimidine) and N -{[1-Benzyl-4-(benzylthio)-6-oxo-1,6-dihydropyrimidin-2yl]carbamothioyl}benzamide (pyrimidine benzamide) for 28 days on some biochemical parameters and hepatic and renal histopathological changes in male albino rats. All the three tested pyrimidine's derivatives showed significant decrease of the body weight, total proteins and significant increase in liver weight and liver index when compared to control group. Additionally, the activities of serum transaminases (ALT and AST) and alkaline phosphate (ALP) were increased significantly in amino pyrimidine, pyridopyrimidine and pyrimidine benzamide treated groups when compared to control group. Moreover, significant inhibition of serum cholinesterase activity (ChE) and hemoglobin (Hb) value were observed with oral administration of the three investigated pyrimidine's derivatives in comparison to control rats. Concerning renal function indicators; serum urea was increased significantly in rats after receiving amino pyrimidine, pyridopyrimidine and pyrimidine benzamide. On the other hand, creatinine levels were increased by administration of amino pyrimidine, pyridopyrimidine and pyrimidine benzamide.The MDA level was detected to be increased significantly and TAC was decreased significantly in rats received amino pyrimidine, pyridopyrimidine, and pyrimidine benzamide. Histopathological examination of rats administered amino pyrimidine, pyridopyrimidine and pyrimidine benzamide, revealed disturbed hepatic and renal architecture that confirm the biochemical results which report hepatic and renal damage. The obtained data demonstrate the toxic effect of the evaluated fused pyrimidine derivatives in male albino rats.

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Vitamin B6 as an Antidote against the Rodenticide ‘Castrix’ (2-Chloro-4-methyl-6-dimethylaminopyrimidin)

Cited by 11 publications

References 2 publications

Crimidine (2‐chloro‐4‐(dimethylamino)‐6‐methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix®

Crimidine (2‐chloro‐4‐(dimethylamino)‐6‐methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix®

Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.

Biological Activity of Fused Pyrimidine Derivatives on Vital Parameters of Male Albino Rats

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