Vitamin C ameliorates high dose Dexmedetomidine induced liver injury

Abstract

BACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses. MATERIAL AND METHODS: Thirty fi ve wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCl intraperitoneally (ip), Dexmedetomidine 5 μg.kg -1 (ip), Dexmedetomidine 5 μg.kg -1 ip plus Vitamin C (100 mg.kg -1 ), Dexmedetomidine 10 μg.kg -1 ip and Dexmedetomidine 10 μg.kg -1 ip plus Vitamin C (100 mg.kg -1 ). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated. RESULTS: Hepatocyte degeneration was signifi cantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were signifi cantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were signifi cantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was signifi cantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively). CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pretreatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30). Text in PDF www.elis.sk.

Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity

“…Interestingly, vitamin C supplementation could attenuate all these indicator inductions in the liver caused by PFOA treatment ( Table 1 ). Although many studies have demonstrated the positive effects of vitamin C on chemical-induced hepatotoxicity and liver injury [17] , [18] , [19] , our study is the first to suggest a protective role of this vitamin in PFOA-induced liver damage. Therefore, to better understand the mechanisms underlying this protective role of vitamin C, integrative omics analyses including comparative transcriptomic and metabolomic analyses for determining the profile changes of genes and metabolites, respectively, was conducted.…”

“…A similar protective effect of vitamin C was reported for fipronil-induced oxidative stress in mouse liver [16] . Furthermore, vitamin C exhibited protective effects on arsenic-induced hepatic anomalies and dexmedetomidine-induced liver injury in rats [18] , [19] .…”

Amelioration of the hepatotoxic effects of nonsteroidal drugs using vitamin C and determination of their relationship with the lipid profile

“…Vitamin C can ameliorate liver tissue damage induced by dexmedetomidine because it protects against toxic free radicals and minimises lipid peroxidation-mediated cellular damage. 39 Vitamin C can also improve the hepatotoxic effects of fenitrothion in rats by reducing oxidative stress. 40 Furthermore, vitamin C can suppress the inflammatory response and endoplasmic reticulum stress-mediated liver damage induced by perfluorooctane sulfonate in mice.…”

Use of Dexmedetomidine in Liver Disease: A Systematic Review and Meta-Analysis

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