Vitamin C and Cardiovascular Disease: A Systematic Review

Ness, Andrew R; Powles, John; Khaw, Kay‐Tee

doi:10.1177/174182679600300606

Cited by 28 publications

(25 citation statements)

References 54 publications

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“…Plasma vitamin C, fruit intake, and dietary vitamin C intake were significantly and inversely associated with mean concentrations of C-reactive protein, an acute phase reactant, and tissue plasminogen activator antigen, a marker of endothelial dysfunction, even after adjustment for confounders. The findings suggest that vitamin C has anti-inflammatory effects and is associated with lower endothelial dysfunction in men with no history of CHD or diabetes [189][190][191][192][193][194][195][196]. Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress.…”

Section: Vitamin C and Immunitymentioning

confidence: 90%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.

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Section: Vitamin C and Immunitymentioning

confidence: 90%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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“…Although we did not have detailed data on dietary or supplemental nutrient intake in our study, our analyses done among subjects reporting knee pain did not support such an explanation. Despite the limited inference possible from the cross-sectional study design, it should be noted that similar use of cross-sectional measures of serum micronutrients has proved informative in studies of cardiovascular disease, in which prospective studies have later corroborated cross-sectional results 32,33 . Second, the measure of carotenoids in serum may be reflective of, but not necessarily specific to, carotenoid levels at the site of action.…”

Section: Discussionmentioning

confidence: 99%

Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project

Roos

Arab

Renner

et al. 2001

Public Health Nutr.

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Objective: Antioxidant intake has been associated with less progression of radiographic knee osteoarthritis (OA), but studies of carotenoid biomarkers and OA have not been done. We examined associations between serum concentrations of nine naturally occurring carotenoids and radiographic knee OA. Design: The study design was matched case±control. Sera were analysed by highperformance liquid chromatography for nine carotenoids: lutein, zeaxanthin, a-and b-cryptoxanthin, trans-and cis-lycopene, a-carotene, and trans-and cis-b-carotene. Conditional logistic regression was used to estimate the association between tertiles of each carotenoid and radiographic knee OA, independent of body mass index, education, serum cholesterol, and the other carotenoids.

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“…Vitamin C (ascorbic acid) is an extremely effective antioxidant that has been demonstrated to have potent antioxidant actions in human plasma and is associated with an 11 % reduction in stroke prevalence (21,139,140) . Vitamin C has been shown to significantly improve endothelium-dependent vasodilatation in diabetics and patients with coronary artery disease, perhaps by reducing excess superoxide production, and thereby decreasing the levels of NO inactivation (141) . Interestingly, there are no studies documenting the role that vitamin C may have in preventing stroke-mediated endothelial cell dysfunction.…”

Section: Antioxidant Vitamins E and Cmentioning

confidence: 99%

“…Nutrition Research Reviews (141) Vitamin C and CVD Review Vitamin C's protective effect against stroke is well documented whereas the evidence that vitamin C is protective against CHD is less consistent Launer & Kalmijn (1998) (125) Antioxidants and cognitive function Review Effect of antioxidants on cognitive impairment or dementia needs further investigation…”

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confidence: 99%

Stroke: roles of B vitamins, homocysteine and antioxidants

2009

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In the present review concerning stroke, we evaluate the roles of B vitamins, homocysteine and antioxidant vitamins. Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. Several studies have reported important benefits on reducing the risk of stroke and improving the post-stroke-associated functional declines in patients who ate foods rich in micronutrients, including B vitamins and antioxidant vitamins E and C. Folic acid, vitamin B6and vitamin B12are all cofactors in homocysteine metabolism. Growing interest has been paid to hyperhomocysteinaemia as a risk factor for CVD. Hyperhomocysteinaemia has been linked to inadequate intake of vitamins, particularly to B-group vitamins and therefore may be amenable to nutritional intervention. Hence, poor dietary intake of folate, vitamin B6and vitamin B12are associated with increased risk of stroke. Elevated consumption of fruits and vegetables appears to protect against stroke. Antioxidant nutrients have important roles in cell function and have been implicated in processes associated with ageing, including vascular, inflammatory and neurological damage. Plasma vitamin E and C concentrations may serve as a biological marker of lifestyle or other factors associated with reduced stroke risk and may be useful in identifying those at high risk of stroke. After reviewing the observational and intervention studies, there is an incomplete understanding of mechanisms and some conflicting findings; therefore the available evidence is insufficient to recommend the routine use of B vitamins, vitamin E and vitamin C for the prevention of stroke. A better understanding of mechanisms, along with well-designed controlled clinical trials will allow further progress in this area.

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Vitamin C and Cardiovascular Disease: A Systematic Review

Cited by 28 publications

References 54 publications

Vitamin C in Disease Prevention and Cure: An Overview

Vitamin C in Disease Prevention and Cure: An Overview

Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project

Stroke: roles of B vitamins, homocysteine and antioxidants

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