Vitamin C and Fertility

Cw, Wilson

doi:10.1016/s0140-6736(73)90919-7

Cited by 21 publications

(6 citation statements)

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“…Dietary supplementation of vitamin C during pregnancy may reduce the frequency of birth defects [21] , has been suggested for pregnant mothers a daily supplement of at least 500 mg of vitamin C starting as early in pregnancy as possible [22]. Deficiencies in antioxidants during pregnancy have been shown to adversely affect fetoplacental unit development, therefore vitamin C intake can play a role in protecting fetal tissues from abnormalities [13] .Women should avoid large doses of vitamin C because it can dry up cervical fluid, preventing sperm from reaching the ova.…”

Section: Vitamin Cmentioning

confidence: 99%

Protective Role of Vitamin C on Histopathological Effect of Formaldehyde on Reproductive System in Female Albino Mice (Histological Study).

Treesh¹

2019

IJAR

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Section: Vitamin Cmentioning

confidence: 99%

Protective Role of Vitamin C on Histopathological Effect of Formaldehyde on Reproductive System in Female Albino Mice (Histological Study).

Treesh¹

2019

IJAR

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“…Thus it is possible that the hypercholesterolaemia in the pregnant guinea-pigs receiving the lower dose of ascorbic acid may have been due to a state of latent vitamin C-deficiency resulting from an increased requirement for the vitamin during pregnancy (Martin er ul. 1957; Wilson & Loh, 1973;Paul & Duttagupta, 1974). The low dose of ascorbic acid would appear to be adequate to prevent a state of hypovitaminosis C in the virgin guinea-pigs since these animals did not exhibit a hypercholesterolaemia.…”

Section: Discussionmentioning

confidence: 99%

“…Gall-stone formation in these animals was associated with an increased hepatic secretion of cholesterol and a decreased secretion of bile acids, the latter being due primarily to a reduction in the secretion of chenodeoxycholic acid (Jenkins, 1978). Since several studies have shown increased requirements for vitamin C during pregnancy (Martin et al 1957;Wilson & Loh, 1973;Paul & Duttagupta, 1974), the following study was undertaken to establish if a reduced ascorbic acid intake during gestation influenced the composition of the bile and hence cholelithiasis.…”

mentioning

confidence: 99%

Vitamin C status, serum cholesterol levels and bile composition in the pregnant guinea-pig

Jenkins

1980

Br J Nutr

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1. Pregnant guinea-pigs receiving a low dose of L-ascorbic acid (0.2 mg/100 g body-weight per d) developed a hypercholesterolaemia in the third trimester of pregnancy, whereas no change in serum cholesterol levels was observed in pregnant animals receiving a higher dose of the vitamin (2 mg/100 g body-weight per d).2. Pregnancy in the group of guinea-pigs receiving the higher dose of L-ascorbic acid was associated with an increased biliary secretion of bile acids. No change was observed in the biliary secretion of bile acids in pregnant animals receiving the lower dose of L-ascorbic acid, but these animals secreted significantly more cholesterol.3. Changes in the biliary secretion of cholesterol and bile acids in the pregnant guinea-pig according to L-ascorbic acid intake were reflected in the composition of the gall-bladder bile. Thus, the gall-bladder bile of guinea-pigs receiving the lower dose of L-ascorbic acid contained more cholesterol, while the gall-bladder bile of those animals receiving the higher dose of the vitamin had a higher content of bile acids.4. The increased cholesterol content of the gall-bladder of pregnant guinea-pigs receiving the lower dose of L-ascorbic acid resulted in decreased bile acid:cholesterol and phospholipid: cholesterol values, conditions predisposing to cholelithiasis.

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“…Large quantities of ascorbate are utilized during conception. Thus, a daily supply of at least 500 µg of vitamin C, starting as early in pregnancy as possible, has been suggested (25). Although a significant influence of AA on reproduction has been proposed by several authors (26), until now, little has been done to examine these proposals in practice.…”

Section: Introductionmentioning

confidence: 99%