Vitamin C intake and the risk of preterm delivery

Siega‐Riz, Anna Maria; Promislow, Joanne H. E.; Savitz, David A.; Thorp, John M.; McDonald, Thad

doi:10.1067/s0002-9378(03)00363-6

Cited by 83 publications

(62 citation statements)

References 14 publications

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“…Both low intakes of vitamin C and folate have been linked with preterm birth. 78,79 Even in women with BN who alternate food restriction with bingeeating, we found that over half of the women with BN studied had less than two-thirds the RDA for calcium, iron, and zinc (when considering nonbinge foods only), and when considering total intake (binge plus non-binge intake) one-fourth reported intake of less than two-thirds the RDA for iron and zinc. 80 Placing these results in context, women with AN tend to maintain low BMI even after recovery.…”

Section: Maternal Bmi and Nutritionmentioning

confidence: 68%

Anorexia nervosa: Definition, epidemiology, and cycle of risk

Bulik

Reba

Siega-Riz

et al. 2005

Int. J. Eat. Disord.

134

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Section: Maternal Bmi and Nutritionmentioning

confidence: 68%

Anorexia nervosa: Definition, epidemiology, and cycle of risk

Bulik

Reba

Siega-Riz

et al. 2005

Int. J. Eat. Disord.

134

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“…20 Therefore, vitamin C plays role in maintaining mechanical and biomechanical strength of the chorioamniotic membranes structure and formation throughout gestation. 1 In 1964, a relationship between maternal vitamin C status and the occurrence of PROM was first proposed that vitamin C plays an essential role in the synthesis of collagen as well as its stabilization by cross-linking. 21 Hadley et al (1990) have shown that there were lower levels of ascorbic acid (vitamin C) in serum, leucocytes, and amniotic fluid of cases with PPROM as compared to the control group yet it was unsure considering the effect of hemodilution.…”

Section: Vitamin C and Prommentioning

confidence: 99%

“…24 In addition, Simhan et al (2005) reported vitamin C usage significantly increased the gestational age at delivery, neonatal Apgar score, birth-weight, and latency period. 29 Siega et al (2003) emphasized by showing groups with vitamin C intake of less than 10 th percentile had twice the risk of preterm delivery because of PROM. 1 Contrary to that, Vermilion et al (2000) showed no difference incidence of PROM between group that received vitamin C plus ferrous sulfate compared to the control group.…”

Section: Vitamin C and Prommentioning

confidence: 99%

“…29 Siega et al (2003) emphasized by showing groups with vitamin C intake of less than 10 th percentile had twice the risk of preterm delivery because of PROM. 1 Contrary to that, Vermilion et al (2000) showed no difference incidence of PROM between group that received vitamin C plus ferrous sulfate compared to the control group. 30 Steyn et al (2003) stated that vitamin C supplementation may only be apparent in the patient with a history of vitamin C deficiency.…”

Section: Vitamin C and Prommentioning

confidence: 99%

“…1 This is one of the most common problems in obstetrics and affects 10-20% of all pregnancies. 2 PROM cause adverse pregnancy outcomes such as preterm delivery and high rates of maternal morbidity and and accounts for 70% perinatal mortality worldwide.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is vitamin C able to prevent premature rupture of membranes?

Aryanti¹

2016

Int J Reprod Contracept Obstet Gynecol

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Macronutrient and Micronutrient Intake Among US Women Aged 20 to 44 Years

Miketinas,

Luo,

Firth

et al. 2024

JAMA Netw Open

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ImportanceNutritional status before and during pregnancy is important for maternal health and fetal growth and development.ObjectiveTo describe secular trends in nutrient intake from foods, beverages, and supplements among pregnant and nonpregnant women of reproductive age in the US.Design, Setting, and ParticipantsThis was a secondary series of cross-sectional analyses of the 1999-2018 National Health and Nutrition Examination Survey (NHANES). Pregnant (n = 1392) and nonpregnant (n = 9737) women aged 20 to 44 years who provided at least 1 reliable dietary recall were included for analysis. These analyses were performed between February 2022 and July 2024.Main Outcomes and MeasuresThe primary outcomes included the mean usual intake of macronutrients and micronutrients, as well as the prevalence of inadequate intake of micronutrients.ResultsThis representative sample included 1392 pregnant women (mean [SE] age, 28.5 [0.3] years) and 9737 nonpregnant women (mean [SE] age, 32.2 [0.1] years). Among pregnant women, a weighted mean (SE) of 27.0% (1.8%) of women were in their first trimester, and 33.8% (2.2%) were in their second trimester. Mean (SE) carbohydrate intake decreased between 1999-2000 and 2013-2018 among pregnant women (306.9 [7.6] to 274.9 [5.7] g/d; β = −2.1 [0.4]; P &lt; .001) and between 1999-2000 and 2017-2018 among nonpregnant women (251.9 [4.9] to 216.9 [3.3] g/d; β = −1.9 [0.4]; P = .002). Between 1999-2000 and 2013-2018, the proportion of pregnant women who consumed below the Estimated Average Requirement of vitamin A increased by 10.9 percentage points (pp) (95% CI, 5.2-16.7 pp), and the proportion of pregnant women who consumed below the Estimated Average Requirement of vitamin C increased by 8.9 pp (95% CI, 3.9-14.0 pp). Similarly, the proportion of nonpregnant women with inadequate intake of vitamin A, vitamin C, and iron increased by 19.9 pp (95% CI, 12.3-27.5 pp), 11.1 pp (95% CI, 4.5-17.7 pp), and 4.9 pp (95% CI, 1.7-8.2 pp), respectively, between 1999-2000 and 2017-2018. The mean (SE) calcium intake increased from 1120.6 (41.4) to 1308.7 (49.0) mg/d for pregnant women (β = 11.7 [4.3]; P = .03) and from 849.5 (19.8) to 981.2 (27.9) mg/d for nonpregnant women (β = 6.7 [2.6]; P = .03; β2 = −1.3 [0.2]; P &lt; .001). Among pregnant women, the prevalence of inadequate intake decreased by 16.1 pp (95% CI, 8.3-23.9 pp) for magnesium (P &lt; .001) and 33.2 pp (95% CI, 24.0-42.4 pp) for vitamin K (P &lt; .001); among nonpregnant women, the proportion with inadequate intake decreased by 16.1 pp (95% CI, 10.4-21.7 pp) for calcium (P &lt; .001), 15.5 pp (95% CI, 7.3-23.6 pp) for magnesium (P &lt; .001), and 33.3 pp (23.5-43.0 pp) for vitamin K (P &lt; .001).Conclusions and RelevanceThis cross-sectional study of pregnant and nonpregnant women of reproductive age found that vitamin A, vitamin C, and iron intake decreased over the past 2 decades, which may have substantial maternal and fetal health implications. By identifying these nutrient gaps and trends in inadequate intake in this at-risk population, scientific, health care, and regulatory communities may be better poised to adopt recommendations to improve nutrient intake.

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Vitamin C intake and the risk of preterm delivery

Cited by 83 publications

References 14 publications

Anorexia nervosa: Definition, epidemiology, and cycle of risk

Anorexia nervosa: Definition, epidemiology, and cycle of risk

Is vitamin C able to prevent premature rupture of membranes?

Macronutrient and Micronutrient Intake Among US Women Aged 20 to 44 Years

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