Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding

Xing, Yaru; Zhao, Bing; Li, Yin; Guo, Mingquan; Shi, Huiping; Zhu, Zhaoqin; Zhang, Lin; He, Juan; Ling, Yun; Gao, Menglu; Lu, Hongzhou; Mao, Enqiang; Zhang, Lijun

doi:10.1016/j.jpba.2021.113927

Cited by 31 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Significant evidence indicates that patients with severe respiratory infections have depleted vitamin C status, with the prevalence of deficiency increasing with the severity of the condition [18][19][20]. The vitamin C status of patients with COVID-19 has been reported in several small observational studies (Table 1) [21][22][23][24][25][26]. Plasma concentrations of vitamin C in most of these patients were reported to be very low with 70-80% of the patients having hypovitaminosis C (plasma concentration <23 µmol/L) [22,24].…”

Section: Vitamin C Status In Patients With Covid-19mentioning

confidence: 99%

Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of Evidence

Holford¹,

Carr

Zawari

et al. 2021

Life

View full text Add to dashboard Cite

Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin. Administration of intravenous vitamin C to patients with pneumonia and sepsis appears to decrease the severity of the disease and potentially improve survival rate. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes pneumonia, sepsis and acute respiratory distress syndrome (ARDS) in severe cases, and is referred to as coronavirus disease 2019 (COVID-19). Patients with COVID-19 infection also appear to have depleted vitamin C status and require additional supplementation of vitamin C during the acute phase of the disease. To date there have been 12 vitamin C and COVID-19 trials published, including five randomised controlled trials (RCTs) and seven retrospective cohort studies. The current level of evidence from the RCTs suggests that intravenous vitamin C intervention may improve oxygenation parameters, reduce inflammatory markers, decrease days in hospital and reduce mortality, particularly in the more severely ill patients. High doses of oral vitamin C supplementation may also improve the rate of recovery in less severe cases. No adverse events have been reported in published vitamin C clinical trials in COVID-19 patients. Upcoming findings from larger RCTs will provide additional evidence on vitamin supplementation in COVID-19 patients.

show abstract

Section: Vitamin C Status In Patients With Covid-19mentioning

confidence: 99%

Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of Evidence

Holford¹,

Carr

Zawari

et al. 2021

Life

View full text Add to dashboard Cite

show abstract

“…Two studies found vitamin C deficient levels in COVID-19 patients [24,25]. Vitamin C levels were undetectable (detection limit 1.5 mg/L) in more than 90% of patients with COVID-19-associated ARDS in a study which was not in the scope of this review [157].…”

Section: Discussionmentioning

confidence: 87%

“…Limitation such as the sample size was related. Xing et al (2021) [25], also found lower plasma vitamin C levels in patients with COVID-19 compared to healthy volunteers.…”

Section: Studies Addressing Vitamin C Status In Hospitalized Patients With Covid-19mentioning

confidence: 83%

Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

Pedrosa

Barros

Leite-Lais

2022

Clinical Nutrition ESPEN

View full text Add to dashboard Cite

The pathogenicity of the current coronavirus disease shows postulates that optimal status of essential nutrients is crucial in supporting both the early viraemic and later hyperinflammatory phases of COVID-19. Micronutrients such as vitamin C, D, zinc, and selenium play roles in antioxidant, antiinflammatory, antithrombotic, antiviral, and immuno-modulatory functions and are useful in both innate and adaptive immunity. The purpose of this review is to provide a high-level summary of evidence on clinical outcomes associated with nutritional risk of these micronutrients observed in patients with COVID-19. A literature search was performed on PubMed and Google Scholar to obtain findings of crosssectional and experimental studies in humans. The search resulted in a total of 1212 reports including all nutrients, but only 85 were included according to the eligibility criteria. Despite the diversity of studies and the lack of randomized clinical trials and prospective cohorts, there is evidence of the potential protective and therapeutic roles of vitamin C, D, zinc, and selenium in COVID-19. The findings summarized in this review will contribute to guide interventions in clinical practice or in future clinical studies.

show abstract

“…Among routine supplementation with multivitamins and minerals, vitamin D deficiency must be assessed [100,101,108,109], as it has been studied that it reduces the risk of the common cold and other similar viral infections [108]. While vitamin C was found to be deficient in COVID-19 patients [110] and could be used to decrease the vulnerability to lower respiratory tract infections, the evidence is still insufficient to support its efficacy to protect people from the SARSCoV2 infection [108,110]. Immunonutrients influence the immune system and improve metabolic and nutritional indices, and can promote patient recovery [104,107,111] by reducing the risk and consequences of infection, including viral respiratory infections [106,107].…”

Section: Dietary Guidelines In Covid-19 Treatmentsmentioning

confidence: 99%

Nutrition in the Actual COVID-19 Pandemic. A Narrative Review

et al. 2021

View full text Add to dashboard Cite

The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global health crisis. The present study discusses the main finding in nutrition sciences associated with COVID-19 in the literature. We conducted a consensus critical review using primary sources, scientific articles, and secondary bibliographic indexes, databases, and web pages. The method was a narrative literature review of the available literature regarding nutrition interventions and nutrition-related factors during the COVID-19 pandemic. The main search engines used in the present research were PubMed, SciELO, and Google Scholar. We found how the COVID-19 lockdown promoted unhealthy dietary changes and increases in body weight of the population, showing obesity and low physical activity levels as increased risk factors of COVID-19 affection and physiopathology. In addition, hospitalized COVID-19 patients presented malnutrition and deficiencies in vitamin C, D, B12 selenium, iron, omega-3, and medium and long-chain fatty acids highlighting the potential health effect of vitamin C and D interventions. Further investigations are needed to show the complete role and implications of nutrition both in the prevention and in the treatment of patients with COVID-19.

show abstract

Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding

Cited by 31 publications

References 31 publications

Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of Evidence

Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of Evidence

Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

Nutrition in the Actual COVID-19 Pandemic. A Narrative Review

Contact Info

Product

Resources

About