Vitamin D: an essential component for skeletal health

Wimalawansa, Sunil J.

doi:10.1111/j.1749-6632.2011.06374.x

Cited by 21 publications

(34 citation statements)

References 123 publications

(243 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among other complications such as sepsis and cholestasis [3,5], patients on PN are at significantly increased risk of developing metabolic bone disease (MBD) [6,7]. This complication, which may manifest as bone pain or pathologic fractures [8], has been shown to disproportionally affect children with IF relative to matched controls [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Pediatric intestinal failure: Predictors of metabolic bone disease

Demehri¹,

Simha²,

Stephens³

et al. 2015

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Pediatric intestinal failure: Predictors of metabolic bone disease

Demehri¹,

Simha²,

Stephens³

et al. 2015

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…Vitamin D is essential for health and is involved in many functions, including the optimal functioning of the musculoskeletal system. Indeed, it stimulates both dietary calcium absorption and osteoid mineralization and has major regulating roles in bone turnover and muscle function (1). Consequently, hypovitaminosis D is associated with defects in bone development in infants as well as with osteoporosis in postmenopausal women, and it can severely impact welfare and health in elderly populations in general.…”

mentioning

confidence: 99%

“…Vitamin D is a generic term that includes several cholesterol-derived compounds, such as vitamin cholecalciferol (D 3 ) and its metabolites 25-hydroxycholecalciferol [25(OH)D 3 ] and 1,25-dihydroxycholecalciferol [1,25(OH) 2 D 3 ]. D 3 can be either synthetized in the skin from 7-dehydrocholesterol under the influence of UV light or provided through the diet.…”

mentioning

confidence: 99%

ABCB1 (P‐glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux

et al. 2018

View full text Add to dashboard Cite

Efficient intestinal absorption of dietary vitamin D is required in most people to ensure an adequate status. Thus, we investigated the involvement of ATP binding cassette subfamily B member 1 (ABCB1) in vitamin D intestinal efflux. Both cholecalciferol (D) and 25-hydroxycholecalciferol [25(OH)D] apical effluxes were decreased by chemical inhibition of ABCB1 in Caco-2 cells and increased by ABCB1 overexpression in Griptites or Madin-Darby canine kidney type II cells. Mice deficient for the 2 murine ABCB1s encoded by Abcb1a and Abcb1b genes ( Abcb1) displayed an accumulation of 25(OH)D in plasma, intestine, brain, liver, and kidneys, together with an increased D postprandial response after gavage compared with controls. 25(OH)D efflux through Abcb1 intestinal explants was markedly decreased compared with controls. This reduction of 25(OH)D transfer from plasma to lumen was further confirmed in vivo in intestine-perfused mice. Docking experiments established that both D and 25(OH)D could bind with high affinity to Caenorhabditis elegans P-glycoprotein, used as an ABCB1 model. Finally, in a group of 39 healthy male adults, a single-nucleotide polymorphism (SNP) in ABCB1 (rs17064) was significantly associated with the fasting plasma 25(OH)D concentration. Thus, we showed here for the first time that ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.-Margier, M., Collet, X., le May, C., Desmarchelier, C., André, F., Lebrun, C., Defoort, C., Bluteau, A., Borel, P., Lespine, A., Reboul, E. ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux.

show abstract

“…Extra-skeletal disorders, such as autoimmune diseases, obesity, type 2 diabetes, and cancer prevention, may require a higher level of serum vitamin D (48)(49)62).…”

Section: Healthy Blood Levels Of Vitamin Dmentioning

confidence: 99%

“…Both the IOM and the Endocrine Society reports recommend increasing the safe intake of vitamin D to 4,000 IU/day (35,52). Serum levels of vitamin D as high as 60 ng/mL are safe, but the long-term safety of levels higher than 60 ng/ mL has not been established (48). Nevertheless, some population-based cross-sectional studies, such as NHANES, give some indication of increased all-cause mortality with high serum levels of vitamin D (63-64).…”

Section: Institute Of Medicine (Iom) 2010 Report On Vitamin Dmentioning

confidence: 99%

Vitamin D: what clinicians need to know

Wimalawansa

2012

Sri Lanka J. Diabetes Endocrinol. Metab.

View full text Add to dashboard Cite

Recent literature on vitamin D is full of controversies regarding its measurement, benefits, diagnosis, and management of its deficiency. In addition to addressing the consequences of deficiency, benefits of its replenishment, and clinical recommendations for supplements, this review addresses extra-skeletal effects of vitamin D. Vitamin D is essential for skeletal health and prevention of falls and injuries. Vitamin D enhances intestinal calcium absorption and mineralization of osteoid tissues. Rickets in children and osteomalacia in adults are classic manifestations of severe vitamin D deficiency. Cohort studies suggest that low 25 hydroxyvitamin D [25(OH)D] affects numerous and diverse physiologic functions, such as control of cell growth including cancer cells, protection against autoimmune disorders, and muscular coordination. Emerging data also suggest that low vitamin D levels may worsen disorders, including cancer, metabolic syndrome, obesity and diabetes, infectious diseases, and autoimmune disorders. Whether increased incidences of these diseases are consequences of widespread vitamin D deficiency is to be determined. Moreover, many reported relationships between vitamin D deficiency and diseases are based on epidemiological observations. Measurement of serum 25(OH)D is the way to evaluate vitamin D status. Serum 25(OH)D levels below 20 ng/mL are considered deficient, whereas optimum levels are between 30 and 50 ng/mL. An additional 1,000 IU of vitamin D per day generally is sufficient for lighter-skinned individuals; elderly, obese, and dark-skinned individuals and other groups of patients may need an additional 2,000 IU or more per day to maintain physiologic serum 25(OH)D levels.

show abstract

Vitamin D: an essential component for skeletal health

Cited by 21 publications

References 123 publications

Pediatric intestinal failure: Predictors of metabolic bone disease

Pediatric intestinal failure: Predictors of metabolic bone disease

ABCB1 (P‐glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux

Vitamin D: what clinicians need to know

Contact Info

Product

Resources

About