Vitamin D and Acute Lower Respiratory Infection in Saskatchewan Children

Ks, Leis; McNally, J. Dayre; Montgomery,; Am, Rosenberg; Sankaran, Koravangattu

doi:10.1093/pch/14.suppl_a.49aa

Cited by 4 publications

(15 citation statements)

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“…Characteristics of the 10 included studies are presented in Table 1. This table contains 7 case-control studies,18–20,22,26,27 1 prospective observational study,24 1 prospective case-control study,13 and 1 matched cohort study 10. Three studies were conducted in China,10,18,20 2 in Iran,13,27 1 in Egypt,19 1 in Poland,26 1 in Italy,24 and 1 in Nigeria 22.…”

Section: Resultsmentioning

confidence: 99%

“…This table contains 7 case-control studies, [18][19][20]22,26,27 1 prospective observational study, 24 1 prospective case-control study, 13 and 1 matched cohort study. 10 Three studies were conducted in China, 10,18,20 2 in Iran, 13,27 1 in Egypt, 19 1 in Poland, 26 1 in Italy, 24 and 1 in Nigeria. 22 The assessment of the methodological quality of the included studies is presented in Table 2.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…7 Multiple studies have attempted to evaluate the involvement of vitamin D deficiency in the pathophysiology of pneumonia in children. [8][9][10][11][12][13][14] Several clinical studies have evaluated the preventive role of vitamin D supplementation as complementary to antibiotic therapy in children with pneumonia. 9 Systematic reviews show that vitamin D supplementation reduces the adverse outcomes related to pneumonia 15 and also has a preventive effect on respiratory tract infections.…”

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confidence: 99%

“…In addition to these treatments, micronutrients and vitamins for the prevention and treatment of pneumonia and its complications have been reported 7. Multiple studies have attempted to evaluate the involvement of vitamin D deficiency in the pathophysiology of pneumonia in children 8–14. Several clinical studies have evaluated the preventive role of vitamin D supplementation as complementary to antibiotic therapy in children with pneumonia 9.…”

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confidence: 99%

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Serum Vitamin D Levels and the Risk of Pneumonia in Children

Huang

2021

Topics in Clinical Nutrition

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This systematic review and meta-analysis aimed to evaluate the association between serum vitamin D concentrations and the risk of pneumonia in children. Human studies reporting serum vitamin D levels in children with pneumonia and healthy controls were collected from different databases. The standardized mean difference and 95% confidence interval were calculated to evaluate the relationship between risk incidence of pneumonia and serum vitamin D levels. The results of analysis showed that serum vitamin D levels in children with pneumonia were significantly lower than those in healthy control children.

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Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Serum Vitamin D Levels and the Risk of Pneumonia in Children

Huang

2021

Topics in Clinical Nutrition

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“…The mean serum levels of serum 25OHD among subjects with recurrent group A streptococcal tonsillo-pharyngitis were significantly lower than those of the controls [Nseir et al 2012], suggesting an association between VD levels and recurrent group A streptococcal tonsillo-pharyngitis in adults. Children with a VD intake of less than 80 IU/kg/day were greater than four times more likely to have acute lower RTIs compared with children with a VD intake exceeding 80 IU/kg/day [Leis et al 2012]. There was a significant correlation between VD deficiency (<15 ng/ml) and the need for supplementary oxygen and ventilator management in acute lower RTIs in hospitalized Japanese children [Inamo et al 2011], suggesting that the immunomodulatory properties of VD may influence the severity of acute lower RTI.…”

Section: Increased Frequency Of Various Respiratory Diseases In Vd Hymentioning

confidence: 91%

Beneficial role of vitamin D₃ in the prevention of certain respiratory diseases

Lương

Nguyễn

2013

Ther Adv Respir Dis

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There is evidence of aberrations in the vitamin D-endocrine system in subjects with respiratory diseases. Vitamin D deficiency is highly prevalent in patients with respiratory diseases, and patients who receive vitamin D have significantly larger improvements in inspiratory muscle strength and maximal oxygen uptake. Studies have provided an opportunity to determine which proteins link vitamin D to respiratory pathology, including the major histocompatibility complex class II molecules, vitamin D receptor, vitamin D-binding protein, chromosome P450, Toll-like receptors, poly(ADP-ribose) polymerase-1, and the reduced form of nicotinamide adenine dinucleotide phosphate. Vitamin D also exerts its effect on respiratory diseases through cell signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the Wnt/β-catenin signaling pathway, prostaglandins, reactive oxygen species, and nitric oxide synthase. In conclusion, vitamin D plays a significant role in respiratory diseases. The best form of vitamin D for use in the treatment of respiratory diseases is calcitriol because it is the active metabolite of vitamin D3 and modulates inflammatory cytokine expression. Further investigation of calcitriol in respiratory diseases is needed.

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The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review

Marusca,

Reddy,

Blaj

et al. 2023

Diseases

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Childhood respiratory tract infections (RTIs) pose a significant health burden, especially in children under six years old. The main objective of this systematic review was to assess the effectiveness of vitamin D supplementation in the prevention of RTI in this population while also exploring potential effect modifiers such as age, baseline vitamin D status, and type of respiratory infection. A systematic review of the literature published up to February 2023 was conducted according to PRISMA guidelines, searching PubMed, Web of Science, Cochrane, and Scopus databases. Eight studies met the inclusion criteria, which investigated the association between vitamin D supplementation and respiratory infections in children between zero and five years old. The included studies were conducted between 2012 and 2021, encompassing a total of 2189 children from five randomized trials, two case-control studies, and one prospective cohort study. The relationship between vitamin D supplementation and the prevention of childhood RTI was not consistently observed across all included studies. Pooled results demonstrated varied effects of vitamin D supplementation on respiratory infection incidence, severity, and symptoms. Three studies reported statistically significant associations between low vitamin D levels and respiratory infections (OR = 4.90, OR = 6.97), while one study found that children who received vitamin D supplementation of 800 UI/day for 3 months during the cold season had fewer episodes of respiratory symptoms (RR = 0.55) and recovered more quickly from acute RTI. Lastly, according to one study, vitamin D intake < 80 IU/kg/day was significantly associated with the risk of acquiring pneumonia (OR 7.9) but not bronchiolitis. The remaining five studies found no statistically significant differences in infection rates or severity (p-value > 0.050). The available evidence on the effectiveness of vitamin D supplementation for preventing and treating respiratory infections in children under six years old is limited, with only a few favorable effects being reported. In some cases, a dose of 80 UI/kg/day was found to provide significant protection for acute respiratory infections, although in the major trials the only benefit was a quicker recovery and fewer respiratory symptoms, with no impact on incidence and severity of respiratory infections. Nevertheless, the study protocol, the supplementation dose, and duration of supplementation had significant variations between studies, leading to inconclusive findings.

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Vitamin D and Acute Lower Respiratory Infection in Saskatchewan Children

Cited by 4 publications

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Serum Vitamin D Levels and the Risk of Pneumonia in Children

Serum Vitamin D Levels and the Risk of Pneumonia in Children

Beneficial role of vitamin D₃ in the prevention of certain respiratory diseases

The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review

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Vitamin D and Acute Lower Respiratory Infection in Saskatchewan Children

Cited by 4 publications

References 0 publications

Serum Vitamin D Levels and the Risk of Pneumonia in Children

Serum Vitamin D Levels and the Risk of Pneumonia in Children

Beneficial role of vitamin D3 in the prevention of certain respiratory diseases

The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review

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Beneficial role of vitamin D₃ in the prevention of certain respiratory diseases