Vitamin D and Calcium as Key Potential Factors Related to Colorectal Cancer Prevention and Treatment: A Systematic Review

Pierard, Stephanie Marie Cruz; Nestares, Teresa; Amaro-Gahete, Francisco J.

doi:10.3390/nu14224934

Cited by 10 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, clinical trials have found that vitamin D supplementation can improve the survival rates of cancer patients 28 . Vitamin D supplementation, as indicated by a systematic review and meta-analysis, was associated with a 30% reduction in overall adverse survival outcomes, a 24% reduction in CRC-speci c death, and a 33% reduction in disease progression or survival 29 .…”

Section: Discussionmentioning

confidence: 99%

The association between vitamin E intake, vitamin D intake and colorectal cancer: evidence from NHANES 2007–2018

Zhu,

Zhang,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: We aimed to investigate the relationship between dietary and supplemental intake of vitamin E and vitamin D and colorectal cancer (CRC) using the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018 in the United States. Method: Data from the NHANES database covering the period 2007 to 2018 were collected. Total vitamin D and vitamin E intake were determined using recall questionnaires for both dietary and dietary supplement intake. CRC patients were identified based on survey questionnaire data. To examine the relationship between vitamin E and vitamin D intake and CRC, we conducted weighted multivariate regression analysis and interaction analysis. Results: Our study included a total of 27,635 participants, among whom 183 individuals (0.6%) were diagnosed with colorectal cancer. After adjusting for all covariates, multivariable logistic regression analysis indicated that total vitamin E intake was not associated with the occurrence of colorectal cancer (P > 0.05). The intake of total vitamin D was also unrelated to the likelihood of colorectal cancer (P > 0.05). Interaction tests revealed no significant impact of these relationships. Conclusion: In summary, the intake of both vitamin D and vitamin E is not associated with the occurrence of colorectal cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

The association between vitamin E intake, vitamin D intake and colorectal cancer: evidence from NHANES 2007–2018

Zhu,

Zhang,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that lactase persistent individuals typically consume more milk than their lactase-non-persistent counterparts [ 67 , 68 ]. Given the known impact of milk consumption on CRC risk [ 26 , 27 , 69 , 70 , 71 , 72 , 73 , 74 ], it is plausible that the protective effect of LPH on CRC risk is partially mediated through catalyzed products of milk [ 75 , 76 , 77 ] and key milk components, namely calcium [ 12 , 13 , 78 ] and vitamin D [ 14 , 79 ]. Other milk-derived compounds, such as butyric acid, conjugated linoleic acid, sphingolipids, and lactoferrin [ 80 , 81 , 82 ], also contribute to the protective effect of LPH.…”

Section: Discussionmentioning

confidence: 99%

“…There is also evidence linking calcium to a lower risk of mutations in the KRAS gene, a significant determinant in the carcinogenesis of CRC [ 6 ]. Vitamin D modulates molecular pathways relevant to CRC development, including the downregulation of the COX-2 gene and the upregulation of 15-hydroxyprostaglandin dehydrogenase (15-PDGH), leading to a reduction in local prostaglandin levels and hence inhibiting cancer cell survival [ 14 ]. Moreover, it interferes with β-catenin-mediated gene transcription, primarily by promoting Vitamin D receptor (VDR) binding to β-catenin, emphasizing its suppressive role on tumor growth [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

“…Diminished LPH levels or activity, leading to lactose maldigestion, are linked to decreased calcium [ 9 ] and vitamin D intake [ 10 ], along with a reduced abundance of beneficial gut bacteria, Bifidobacterium [ 11 ]. Observational studies have reported that reduced calcium [ 12 , 13 ] and vitamin D [ 14 , 15 ] intake are associated with increased CRC risk, suggesting protective roles of calcium and vitamin D in CRC development. In addition, clinical studies have shown that dietary intake of Bifidobacterium modulates gut microbiota towards CRC prevention [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Han,

Yao,

Yamazaki

et al. 2024

Nutrients

View full text Add to dashboard Cite

Previous research has found that milk is associated with a decreased risk of colorectal cancer (CRC). However, it is unclear whether the milk digestion by the enzyme lactase-phlorizin hydrolase (LPH) plays a role in CRC susceptibility. Our study aims to investigate the direct causal relationship of CRC risk with LPH levels by applying a two-sample Mendelian Randomization (MR) strategy. Genetic instruments for LPH were derived from the Fenland Study, and CRC-associated summary statistics for these instruments were extracted from the FinnGen Study, PLCO Atlas Project, and Pan-UK Biobank. Primary MR analyses focused on a cis-variant (rs4988235) for LPH levels, with results integrated via meta-analysis. MR analyses using all variants were also undertaken. This analytical approach was further extended to assess CRC subtypes (colon and rectal). Meta-analysis across the three datasets illustrated an inverse association between genetically predicted LPH levels and CRC risk (OR: 0.92 [95% CI, 0.89–0.95]). Subtype analyses revealed associations of elevated LPH levels with reduced risks for both colon (OR: 0.92 [95% CI, 0.89–0.96]) and rectal cancer (OR: 0.92 [95% CI, 0.87, 0.98]). Consistency was observed across varied analytical methods and datasets. Further exploration is warranted to unveil the underlying mechanisms and validate LPH’s potential role in CRC prevention.

show abstract

“…However, the evidence on whether vitamin D intake or serum levels affect cancer incidence, progression, or mortality is mixed in observational studies and clinical trials. A large number of studies reported that higher intake or circulating vitamin D was associated with a decreased CRC risk ( 12 – 14 ). Conversely, these are null findings from randomized trials and systematic reviews ( 15 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

Adequate vitamin D level associated with reduced risk of sporadic colorectal cancer

Deng

Huangfu

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

PurposeThe effect of vitamin D level pertinent to colorectal cancer incidence, progression, or mortality risk is complicated, and study findings are mixed. Therefore, we evaluated whether serum vitamin D [25-hydroxyvitamin D, 25(OH)D] is associated with the incidence of sporadic colorectal cancer (CRC).MethodsThis study is a retrospective analysis of the relationship between serum 25(OH)D level and the risk of CRC. Age, sex, body mass index, history of polyp, disease conditions (i.e., diabetes), medications, and other eight vitamins were used as confounding factors. A total of 389 participants were enrolled in this study, including comprising 83 CRC patients without a family history and 306 healthy controls, between January 2020 and March 2021 at the Department of Colorectal Surgery and Endoscope Center at the Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. Adjusted smoothing spline plots, subgroup analysis, and multivariate logistic regression analysis were conducted to estimate the relative risk between serum 25(OH)D and sporadic CRC risk.ResultsAfter fully adjusting the confounding factors, it was found that circulating 25(OH)D played a protective role in patients with CRC (OR = 0.76 [0.63, 0.92], p = 0.004) and that an adequate vitamin D level was significantly associated with a reduced CRC risk compared to vitamin D deficiency or sufficiency (OR = 0.31 [0.11, 0.9], p = 0.03). According to this study, statins did not affect the potential protective effects of vitamin D (OR = 1.02 [0.97, 1.08], p = 0.44) and may account for the inverse association between serum 25(OH)D and colorectal cancer.ConclusionAn adequate level of serum 25(OH)D was associated with a reduced CRC risk, especially for the elderly. The finding on the absence of protective effect of vitamin D in the statin use subgroup, suggests it may be one of the substantial contributing confounders, and warrants further investigation.

show abstract

Vitamin D and Calcium as Key Potential Factors Related to Colorectal Cancer Prevention and Treatment: A Systematic Review

Cited by 10 publications

References 36 publications

The association between vitamin E intake, vitamin D intake and colorectal cancer: evidence from NHANES 2007–2018

The association between vitamin E intake, vitamin D intake and colorectal cancer: evidence from NHANES 2007–2018

Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Adequate vitamin D level associated with reduced risk of sporadic colorectal cancer

Contact Info

Product

Resources

About