Vitamin D and Calcium Supplement Use and High-Risk Breast Cancer: A Case–Control Study among BRCA1 and BRCA2 Mutation Carriers

Guyonnet, Emma; Kim, Shana J.; Pullella, Katherine; Zhang, Cindy X.; McCuaig, Jeanna; Armel, Susan; Narod, Steven A.; Kotsopoulos, Joanne

doi:10.3390/cancers15102790

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Studies addressing CaD supplementation in the context of BC prevention are indeed scarce. Most articles in the scientific literature focus on the study of supplementation of both factors separately [ 117 , 118 ], so combined CaD supplementation and its association with BC risk require further research.…”

Section: Resultsmentioning

confidence: 99%

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review

Torres,

Cameselle,

Otero

et al. 2024

Nutrients

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Vitamin D deficiency is currently a significant public health issue closely linked to numerous diseases, such as breast cancer. This study aims to determine the estimated optimal serum levels of vitamin D to have a protective effect against breast cancer, in addition to exploring the biological mechanisms and risk factors involved. A literature search of articles published in the last 5 years was conducted, and simple statistical analyses using mean and standard deviation were performed to calculate the average concentration of vitamin D from different available studies. It has been observed that serum levels of vitamin D ≥ 40.26 ng/mL ± 14.19 ng/mL could exert a protective effect against breast cancer. Additionally, various biological mechanisms, such as those related to the immune system, and risk factors like diet implicated in this relationship were elucidated. Consequently, it can be concluded that proper serum levels of vitamin D may have a protective effect against breast cancer, and dietary supplementation may be an appropriate procedure to achieve these optimal vitamin D concentrations.

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Section: Resultsmentioning

confidence: 99%

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review

Torres,

Cameselle,

Otero

et al. 2024

Nutrients

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“…We hypothesize that our cancer group could have been better self-educated and made attempts at healthier nutrition, regardless of the fact that such behaviors do not act as prophylaxis at that stage of the disease. Guyonnet et al reported that an increased intake of vitamin D and calcium lowered the risk of developing breast cancer, mainly among the carriers of the BRCA1 gene [ 42 ]. It has also been demonstrated that higher consumption of essential amino acids, which are mainly found in dairy products—leucine, isoleucine, and valine—is associated with longer survival among breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Eating Behaviors and Physical Activity versus the Big Five Personality Traits in Women with a Hereditary Predisposition to Breast or Ovarian Cancer

Pięta,

Bień,

Pięta

et al. 2024

Nutrients

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The Big Five personality traits—neuroticism, extroversion, openness to experience, agreeableness, and conscientiousness—represent continuous, individual features that affect a number of vital health aspects, including morbidity, self-reported health status, or lifestyle. The aim of this study was to analyze the relationship between the eating behaviors and engagement in physical activity of women with a hereditary predisposition to breast or ovarian cancer and the Big Five personality traits. A total of 357 women, participants of ‘The National Program for Families With Genetic/Familial High Risk for Cancer’, were included in the study. In the healthy group, the following statistically significant predictors were found in variables: agreeableness—meal frequency (β = 0.151; p = 0.030); neuroticism—consumption of fruits and vegetables (β = −0.177; p = 0.016) and cereal products (β = −0.223; p = 0.002); openness to experience—consumption of plant-based fats (β = 0.141; p = 0.034) and physical activity (β = 0.153; p = 0.021). In the cancer group, the frequency of dairy consumption (β = 0.286; p = 0.003) and physical activity (β = 0.370; p = 0.000) were found to be statistically significant predictors for the openness to experience variable. Neuroticism is associated with less frequent consumption of fresh fruits and vegetables as well as cereal products. Openness to experience was more often linked with a higher frequency of dairy consumption, plant-based fats, and physical activity. Women with breast or ovarian cancer and a higher openness to experience consumed dairy and engaged in physical activity more often than their peers with the remaining personality traits.

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Vitamin D deficiency and malignancies

Krivosheev,

Bilan

2023

Sanitary Doctor

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The analysis of domestic and foreign literature shows that oncological diseases are most often accompanied by a low level of 25(OH)D in the blood serum of patients and a high prevalence of deficiency and severe deficiency of vitamin D. It can be confidently stated that the level of 25(OH)D in serum blood of oncological patients, on average, is lower than in healthy people of the corresponding sex and age. In this regard, statistical studies were carried out, which demonstrated the prevalence of vitamin D deficiency in the countries of Europe and North America, which is directly proportional to the level of annual mortality from cancer and the probability of death from cancer, any type of cardiovascular disease, diabetes and chronic respiratory diseases, and this relationship is statistically significant (p < 0.001). Oncological morbidity and mortality from cancer in the Russian Federation naturally increases especially in higher latitudes, which, along with other reasons, is associated with a limitation in the duration of the effective production of vitamin D3 in human skin under the influence of ultraviolet radiation. Some clinical studies of vitamin D supplementation as a therapeutic agent are showing measurable positive results in cancer, with far more positive than in placebo groups. However, negative results that are harmful to patients participating in clinical experiments have not been established in the study of many hundreds of studied articles on this issue. The most commonly seen beneficial effects of vitamin D supplementation have been in the treatment of breast and colorectal cancer, which are particularly noticeable in patients with low baseline serum levels of 25(OH)D and high daily doses of 25(OH)D3 supplementation well above standard recommendations of 400–800 IU daily. Due to the high prevalence of vitamin D deficiency among cancer patients, taking into account international positive experience, it seems very useful and necessary to create domestic scientific foundations and expand the clinical practice of using vitamin D supplements as a therapeutic agent for cancer.

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Vitamin D and Calcium Supplement Use and High-Risk Breast Cancer: A Case–Control Study among BRCA1 and BRCA2 Mutation Carriers

Cited by 3 publications

References 25 publications

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review

Eating Behaviors and Physical Activity versus the Big Five Personality Traits in Women with a Hereditary Predisposition to Breast or Ovarian Cancer

Vitamin D deficiency and malignancies

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