Vitamin D and its therapeutic relevance in pulmonary diseases

Ahmad, Shaniya; Arora, Shweta; Khan, Salim; Mohsin, Mohd; Mohan, Anant; Manda, Kailash; Syed, Mansoor Ali

doi:10.1016/j.jnutbio.2020.108571

Cited by 50 publications

(28 citation statements)

References 186 publications

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“…Vitamin D has recognized effects in the immune system and defense against infectious diseases, particularly viral respiratory infections [ 78 ]. It has been demonstrated that vitamin D reinforces mucosal integrity and counteracts the inflammatory response which contributes to acute respiratory distress syndrome and lung injury [ 79 ]. Recent studies published in the literature have investigated these immune-modulating properties of vitamin D against coronavirus disease 2019 (COVID-19), the severe acute respiratory syndrome caused by the SARS-CoV-2 virus, that has affected the world since the end of 2019, with controversial findings [ 80 , 81 ].…”

Section: Vitamin D and Covid-19 In Parkinson’s Diseasementioning

confidence: 99%

Vitamin D Status and Parkinson’s Disease

et al. 2022

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Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field.

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Section: Vitamin D and Covid-19 In Parkinson’s Diseasementioning

confidence: 99%

Vitamin D Status and Parkinson’s Disease

et al. 2022

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“…11 Low vitamin D level has been linked to inflammation modulation, impaired host defense, elevation of protease expression, and airway remodeling. 25 An imbalance between protease and anti-protease was found in the lungs of patients with COPD. Protease works to break down connective tissue components and anti-protease works to inhibit the breakdown process.…”

Section: Dovepressmentioning

confidence: 99%

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Soeroto¹,

Setiawan²,

Asriputri³

et al. 2021

IJGM

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Purpose: This study aimed to assess the association between vitamin D levels and forced expiratory volume in one second (FEV1), number of exacerbations, and symptoms based on COPD assessment test (CAT) scores in stable COPD patients in Indonesia. Patients and Methods: An observational cross-sectional study was conducted. Subjects were stable COPD patients who were treated at a pulmonary clinic in a tertiary referral hospital in West Java from March to June 2018. Results: Thirty subjects were recruited this study with an average age 62±8 years. The mean vitamin D level was 20.17±8.91 ng/mL. Half of the patients had low vitamin D level (<20ng/ mL) (50%). The mean FEV1 (%) predicted value was 37.2±14. The median exacerbation per year was 1 (0-5) and symptoms based on CAT score was 14 (3-34). No correlation was found between vitamin D levels and FEV1 (%) predicted value (r=0.126, p=0.253). Vitamin D level was inversely correlated with number of exacerbations (r=−0.639, p<0.001) and CAT (r= −0.802, p<0.001). Conclusion: Low level of vitamin D was associated with more frequent exacerbation and higher CAT scores but was not associated with FEV1 (%) predicted.

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“…Animal studies have reported the potential biological roles of vitamin D in alveolar and vascular development—including in the differentiation of type II pneumocytes, lung mesenchymal stem cells, and vascular endothelial cells—and in the synthesis and secretion of surfactant phospholipids ( 36 – 38 ). In addition, vitamin D also modulates immune processes and the proliferation and differentiation of numerous other cell types ( 39 ). As a result, vitamin D deficiency contributes to several respiratory complications and lung function impairments in premature infants, including airway hyperresponsiveness, increased resistance, and reduced compliance ( 15 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Utility of umbilical cord blood 25-hydroxyvitamin D levels for predicting bronchopulmonary dysplasia in preterm infants with very low and extremely low birth weight

Fu²,

Feng³

2022

Front. Pediatr.

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Background and objectiveThere remains controversy regarding vitamin D deficiency and bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) and extremely low birth weight (ELBW) preterm infants. This study aimed to determine the prevalence of vitamin D deficiency assessed by umbilical cord blood 25-hydroxyvitamin D [25(OH)D] in preterm infants in northeast China and to evaluate the ability and optimal threshold of 25(OH)D for predicting BPD.MethodsThe clinical data of VLBW and ELBW preterm infants with known cord-blood 25(OH)D levels were analyzed retrospectively. Infants were divided into groups based on their cord-blood 25(OH)D levels and BPD diagnosis. Logistic regression was performed to assess the risk factors for BPD and a nomogram was established. Receiver operating characteristic (ROC) curve analysis was used to evaluate the optimal threshold of cord-blood 25(OH)D concentration for predicting BPD.ResultsA total of 267 preterm infants were included, of which 225 (84.3%) exhibited vitamin D deficiency and 134 (50.2%) were diagnosed with BPD. The incidence of BPD was lower in the group with a 25(OH)D level of >20 ng/ml than in the other groups (P = 0.024). Infants with BPD had lower cord-blood 25(OH)D levels than those without BPD (11.6 vs. 13.6 ng/ml, P = 0.016). The multivariate logistic regression model revealed that 25(OH)D levels (odds ratio [OR] = 0.933, 95% confidence interval [95% CI]: 0.891–0.977), gestational age (OR = 0.561, 95% CI: 0.425–0.740), respiratory distress syndrome (OR = 2.989, 95% CI: 1.455–6.142), and pneumonia (OR = 2.546, 95% CI: 1.398–4.639) were independent risk factors for BPD. A predictive nomogram containing these four risk factors was established, which had a C-index of 0.814. ROC curve analysis revealed that the optimal cutoff value of 25(OH)D for predicting BPD was 15.7 ng/ml (area under the curve = 0.585, 95% CI: 0.523–0.645, P = 0.016), with a sensitivity of 75.4% and a specificity of 42.9%.ConclusionsA cord-blood 25(OH)D level of <15.7 ng/ml was predictively valuable for the development of BPD. The nomogram established in this study can help pediatricians predict the risk of BPD more effectively and easily.

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Vitamin D and its therapeutic relevance in pulmonary diseases

Cited by 50 publications

References 186 publications

Vitamin D Status and Parkinson’s Disease

Vitamin D Status and Parkinson’s Disease

Association Between Vitamin D Levels and FEV1, Number of Exacerbations, and CAT Score in Stable COPD Patients in Indonesia

Utility of umbilical cord blood 25-hydroxyvitamin D levels for predicting bronchopulmonary dysplasia in preterm infants with very low and extremely low birth weight

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