Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Tirabassi, Giacomo; Sudano, Maurizio; Salvio, Gianmaria; Cutini, Melissa; Muscogiuri, Giovanna; Corona, Giovanni; Balercia, Giancarlo

doi:10.1155/2018/3720813

Cited by 23 publications

(26 citation statements)

References 36 publications

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“…Notably, we observed a significant association between higher vitamin D levels and higher testosterone concentrations only in men older than 56 years of age. Previous studies have yielded conflicting results regarding associations between testosterone and vitamin D levels [15][16][17]. Our results therefore suggest the possibility that the age of subjects may play an important role in accounting for some of the variations in vitamin D levels that have been previously observed.…”

Section: Discussionmentioning

confidence: 49%

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Samoszuk¹,

Morgentaler

Groot

et al. 2019

Int J Impot Res

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Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI). In a smaller exploratory study of 19 otherwise healthy men presenting for evaluation of possible hypogonadism, pre-albumin (a.k.a. transthyretin, a marker of anabolism) and testosterone were measured. Men with lower levels of testosterone had significantly (p < 0.001) lower mean levels of PSA, SHBG, luteinizing hormone, and estradiol. Overall, men with low levels of testosterone also had significantly (p < 0.001) higher mean levels of LDH and BAP, but these associations varied between men who were younger or older than 56 years. There was a moderate but statistically significant positive correlation (r = 0.63, p < 0.05) between testosterone levels and pre-albumin. These results confirm our hypothesis that testosterone deficiency is associated with a broad range of systemic changes demonstrable in hormonal and non-hormonal serum assays in men over 40 years old being tested for possible hypogonadism.

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Section: Discussionmentioning

confidence: 49%

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Samoszuk¹,

Morgentaler

Groot

et al. 2019

Int J Impot Res

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“…One study included 102 males having vitamin D levels under 30 ng/ml, with a 12-month follow-up that received vitamin D replacement therapy, and found both self-reported IIEF-5 score and serum testosterone levels exhibited a stepladder increases in the follow-up duration (Canguven, Talib, Ansari, Yassin, & Al Naimi, 2017). Along with this same line, erection function showed a significant improvement after vitamin D replacement therapy in another longitudinal study (Tirabassi et al, 2018). However, in another study cohort, assessing the effect of vitamin D supplementation in dialysis patients, there were no significant changes in sexual parameters (Blumberg et al, 1980).…”

Section: Discussionmentioning

confidence: 92%

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

2018

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Suboptimal levels of serum vitamin D levels have been implied to be associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). The present systematic review and meta-analysis was performed to evaluate the vitamin D levels in subjects with ED compared to controls and the 5-item version of the international index of erectile function (IIEF-5) score in subjects with vitamin D deficiency compared to those without vitamin D deficiency in order to elucidate the role of vitamin D in the pathogenesis of ED. Studies evaluating the possible association between vitamin D levels and ED were initially screened and thus included following electronic literature search of database Cochrane Library, PUBMED, EMBASE and MEDLINE. Essential article information including outcome measures was extracted from the qualified studies by two independent authors, and STATA 12.0 software was used conducted the meta-analysis. Subgroup analyses were conducted by vitamin D detection methods and sample size. The standard mean difference (SMD) as well as the 95% confidence intervals (95% CIs) was applied to estimate the outcome measures. A total of seven articles were included in our meta-analysis with a total of 4,132 subjects. Pooled estimate was in favour of increased vitamin D levels in subjects without ED with a SMD of 3.027 ng/ml, 95%CI 2.290-3.314, p = 0.000. However, subgroup analysis showed an opposite trend, after one study with a sample size over 1,000 that could possibly influence the weight balance was excluded, with a SMD of 0.267, 95%CI −0.052 to 0.585, p = 0.101. We also identified about 0.320 higher in IIEF-5 score (95%CI = 0.146-0.494, p = 0.000) in subjects without vitamin D deficiency versus with vitamin D deficiency. Nevertheless, subgroup analysis based on vitamin D detection methods obtained differential results (radioimmunoassay subgroup, SMD(95%CI) = 0.573 (0.275-0.870), p = 0.000; immunoassay subgroup, SMD(95%CI) = 0.189 (−0.025 to 0.404), p = 0.084). In conclusion, results from the present meta-analysis did not provide a strong relationship between vitamin D and the risk of ED. However, the results should be interpreted with caution and more high quality studies are warranted. K E Y W O R D S5-item version of the international index of erection function, erectile dysfunction, metaanalysis of VD and ED, meta-analysis, vitamin D

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“…Therefore, 13 were found suitable for inclusion in this study. Three of these latter studies were excluded for the study design: they were intervention studies [13][14][15]. The articles by Bellastella and colleagues [17] and Zhang and colleagues [18] were excluded because we could not extract useful data for the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The few studies of this type have given conflicting results. In fact, Tirabassi and colleagues have shown that vitamin D supplementation, given until normal circulating levels were restored, is associated with an improvement in ED that is independent of circulating testosterone levels [13]. Similarly, Canguven and colleagues estimated that supplementation with 600,000 units of ergocalciferol per month for 12 months is associated with a progressive improvement in ED and an increase of serum testosterone levels [14].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, almost all of these studies included a cohort of patients with important comorbidities (e.g., diabetes mellitus, renal failure, hypogonadism, benign prostatic hyperplasia) [8][9][10][11][12][13][14][15][16][17][18], which in themselves are well-known causes of ED. Furthermore, very few studies have evaluated the effects of vitamin D supplementation on sexual dysfunction [13][14][15][16]. Therefore, the purpose of this meta-analysis was to evaluate the levels of 25(OH)D 3 among patients with and without ED and if the severity of ED is different in patients with and without vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

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Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis

et al. 2020

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Erectile dysfunction (ED) is found very frequently in the male population, in particular in its arteriogenic form, which also represents an important predictor of cardiovascular diseases (CVDs). Some evidence suggests that vitamin D could play a role in cardiovascular risk prevention thanks to its ability to reduce endothelial damage, oxidative stress, the production of inflammatory cytokines, and dyslipidemia. Since ED and CVDs have pathogenic mechanisms in common, numerous studies have evaluated a possible association between vitamin D deficiency (blood concentrations of 25-hydroxyvitamin D < 20 ng/mL) and ED, but with conflicting results. This meta-analysis was therefore performed to clarify the discrepancy of the data so far published. To achieve this, articles have been searched extensively in the Pubmed, MEDLINE, Cochrane, Academic One Files, Google Scholar, and Scopus databases from the first day they were created until January 2020. The search strategy included pertinent Medical Subjects Headings (MeSH) terms. Of the 431 items retrieved, only eight observational studies were included, resulting in a total sample size of 4055 patients. It was found that 25-hydroxyvitaminD (25(OH)D) levels did not show any significant difference between patients with and without ED. However, when patients with vitamin D deficiency only were taken into account, the international index of erectile function (IIEF) score for erectile dysfunction was significantly worse than in controls. This association remained significant even when eugonadal-only patients were considered. Finally, we found that eugonadal patients with severe ED have lower 25(OH)D3 levels than patients with mild ED. In conclusion, this meta-analysis suggests an association between vitamin D deficiency and the presence of severe forms of ED, independent of testicular function.

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Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Cited by 23 publications

References 36 publications

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Association of low testosterone with changes in non-cardiovascular biomarkers in adult men

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis

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