Vitamin D and muscle strength, functional ability and balance in peritoneal dialysis patients with vitamin D deficiency

Taşkapan, Hülya; Baysal, Özlem; Karahan, Dogu; Durmuş, Bekir; Altay, Zühal; Ulutaş, Özkan

doi:10.5414/cn107160

Cited by 48 publications

(30 citation statements)

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“…Similar results were reported of beneficial effects on muscular performance and injury occurrence in elite ballet dancers [10]. Further, when patients suffering from chronic kidney failure (with or without the need for dialysis) were supplemented with vitamin D an improvement of muscle strength, functional ability and balance was observed [11]. Muscle strength and performance for elderly was reported to be best for levels >75 nmol/L [12].…”

Section: Discussionsupporting

confidence: 72%

Do Professional Soccer Players have a Vitamin D Status Supporting Optimal Performance in Winter time?

G¹

2014

J Sports Med Doping Stud

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Background: Vitamin D is well known for its role in calcium homeostasis and bone metabolism. In addition 25 (OH) vitamin D3 (25OHD3) deficiency is correlated with muscle pain and weakness, hence there is increasing interest in optimal 25OHD3 levels for athletes. We investigated the prevalence of 25OHD3 deficiency and the ethnical variation in 25(OH)D concentrations among professional soccer players in the winter season.

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Section: Discussionsupporting

confidence: 72%

Do Professional Soccer Players have a Vitamin D Status Supporting Optimal Performance in Winter time?

G¹

2014

J Sports Med Doping Stud

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“…Similarly, Ardawi et al 20 found that sedentary life and lack of physical activity are associated with lower levels of vitamin D. Nonetheless, it is not clear whether the physical activity is a factor that leads to increases in vitamin D level, or conversely it is vitamin D that improves physical activity. In fact, studies of dialysis patients 25,26 and older frail people 27,28 demonstrated an amelioration of the abilities of physical exertion, and subsequently improved the quality of life of these persons. Such a reciprocal relation cannot be disentangled in cross-sectional or retrospective designs, and needs prospective research.…”

Section: Discussionmentioning

confidence: 99%

Comparison of vitamin D deficiency in Saudi married couples

2012

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BACKGROUND/OBJECTIVE: Vitamin D deficiency is highly prevalent in Saudi Arabia. The study objective was to compare vitamin D deficiency in Saudi married couples. SUBJECTS/METHODS: This cross-sectional study was carried out in the Royal Guard primary health care center in Riyadh, Saudi Arabia on a consecutive sample of 50 Saudi married couples attending the center without complaints related to vitamin D deficiency. Data were collected through an interview questionnaire addressing the risk factors and dietary habits. Quantitative determination of total 25-hydroxy vitamin D in blood was done by Electro-Chemical Luminescence assay. Fieldwork was carried out from December 2010 to January 2011. RESULTS: Men had higher sun exposure (P ¼ 0.001), more use of light clothes at home (P ¼ 0.002) and more intake of milk (P ¼ 0.023) and soft drinks (P ¼ 0.001). Vitamin D was higher in men with mean difference about 9 nmol/l (Po0.001). The prevalence of vitamin D deficiency (o25 nmol/l) was 70% in women, compared with 40% in men (P ¼ 0.001). Multivariate analysis identified male gender, physical activity and the intake of milk as statistically significant positive independent predictors of vitamin D level, adjusted for factors as age, sun exposure, clothing, skin color, BMI, soft drinks and animal protein intake. CONCLUSION: Vitamin D deficiency is very high among Saudi married couples, especially wives. Female gender is an independent predictor of lower vitamin D level, in addition to sedentary lifestyle and low milk consumption. There is a need to revise the levels set for the diagnosis of vitamin D deficiency or insufficiency in the study region.

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“…Many studies have evaluated vitamin D (either cholecalciferol or ergocalciferol) as a treatment for vitamin D insufficiency or SHPT in adults with predialysis CKD [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]. Most were open-label studies and some were conducted in patients exhibiting SHPT.…”

Section: Discussionmentioning

confidence: 99%

Modified-Release Calcifediol Effectively Controls Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease

et al. 2014

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Background/Aims: Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D repletion therapy: a modified-release (MR) formulation of calcifediol designed to raise serum 25-hydroxyvitamin D in a gradual manner to minimize the induction of CYP24 and, thereby, improve the SHPT control. Methods: This randomized, double-blind, placebo-controlled trial evaluated MR calcifediol in CKD subjects (n = 78) with plasma intact parathyroid hormone (iPTH) >70 pg/ml and serum total 25-hydroxyvitamin D <30 ng/ml. Subjects received daily treatment for six weeks with oral MR calcifediol (30, 60 or 90 µg) or a placebo. Results: More than 90% of subjects treated with MR calcifediol achieved serum 25-hydroxyvitamin D levels ≥30 ng/ml versus 3% of subjects treated with placebo (p < 0.0001). Mean plasma iPTH decreased from baseline (140.3 pg/ml) by 20.9 ± 6.2% (SE), 32.8 ± 5.7 and 39.3 ± 4.3% in the 30, 60 and 90 µg dose groups, respectively, and increased 17.2 ± 7.8% in the pooled placebo group (p < 0.005). No clinically significant safety concerns arose during MR calcifediol treatment. Conclusion: Oral MR calcifediol appears safe and highly effective in treating SHPT associated with vitamin D insufficiency in CKD.

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Vitamin D and muscle strength, functional ability and balance in peritoneal dialysis patients with vitamin D deficiency

Cited by 48 publications

References 0 publications

Do Professional Soccer Players have a Vitamin D Status Supporting Optimal Performance in Winter time?

Do Professional Soccer Players have a Vitamin D Status Supporting Optimal Performance in Winter time?

Comparison of vitamin D deficiency in Saudi married couples

Modified-Release Calcifediol Effectively Controls Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease

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