COVID-19, which affects the whole world, has affected people, societies and human relations throughout the process. The COVID-19 pandemic both limited people's social lives and changed the perspective of people who carry the virus. Anxiety, fear, haste, loneliness, worry were the most common emotions. In this study, we aimed to evaluate how social warnings affect people, the effects of death risk due to the disease, the side effects of the drugs used on behavior change, and the underlying factors. 189 cases were included in the study. The study was designed in the style of a 20-question questionnaire on the effects of covid-19 and treatment options on the behavior pattern. The responses were evaluated and interpreted as percentages. Variables on family and social behavior related to anxiety, fear, panic, and loneliness caused by COVID-19 and the drugs used in its treatment were observed. Negative effects of COVID-19 were observed in family and community relations. COVID-19 has caused psychological and sociological changes in interpersonal and social behaviors all over the world. There are differences in behavioral patterns among societies. In Turkish society, behavioral changes arising from the characteristic and patriarchal characteristics of the society have been observed. A more detailed assessment of the effects of COVID-19 and subsequent pandemics on the individual and society remains important.
Background
Familial Mediterranean Fever (FMF) is a genetic auto-inflammatory disease. Mutations in the MEFV gene cause inappropriate immune system triggering, leading to inflammatory episodes in the peritoneum, pleura, and joints. In the severe COVID-19 picture, the hyperimmune response and inflammatory process develop and the clinic worsens. The FMF disease, the drugs used for its treatment, and the situation that different genetic mutations will display in the course of COVID-19 arouse interest.
Methods
In this study, common and different points in COVID-19 follow-up processes were evaluated by online questionnaire method according to different gene mutations in 158 FMF patients who had gene analysis. Participants were asked 21 questions and the data provided were compared between FMF MEFV gene mutations
Results
104 out of 158 cases did not get COVID-19. 8 of 54 cases who get COVID-19 were hospitalized. No statistically significant difference was found between gene mutations when evaluated and compared in terms of susceptibility to COVID-19, vaccination status and presence of additional chronic diseases.
Conclusion
The present study provides guidance on the role of FMF genetic mutations in the course of COVID-19. Our study may suggest that FMF MEFV gene mutations do not have a protective role against COVID-19. The results also suggest that, as an inverse effect, MEFV gene mutations do not increase the risk of hyper-immune response and SARS, which play a role in the severe course of COVID-19.
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