Vitamin D and Primary Immunodeficiencies

Paulino, Talita Lemos; Rafael, Marina Neto; Silva, Rosangela da; Santos-Valente, Elisangela; Souza, Fabíola Isabel Suano de; Sarni, Roseli Oselka Saccardo; Costa‐Carvalho, Beatriz Tavares

doi:10.9734/bjmmr/2015/17469

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…In our study, there was no significant difference between groups in IgM while IgG were found to be significantly decreased in vitamin D deficiency group compared to vitamin D resistance group. This runs with Paulino et al (10) documented that in the group of children with IgG deficiencies, vitamin D concentrations were significantly lower than in other patients without IgG deficiencies, something that was also observed in patients with primary and secondary immunodeficiency. Also, Dąbrowska-Leonik et al (11) demonstrated that patients with reduced Ig G had statistically-significant lower vitamin D concentrations than children with normal concentrations of IgG and they found that IgG deficiency does not result from the synthesis-inhibiting effect of vitamin D. Moreover, they showed that vitamin D3 supplementation was needed in patients with reduced IgG levels, and also in the case of associated reduced IgA and IgM concentrations.…”

Section: Discussionsupporting

confidence: 80%

Serum Immunoglobulins in Children with Vitamin D Resistant Rickets

Amin

Kamal

Gaballah³

et al. 2019

Suez Canal University Medical Journal

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Background: Vitamin D plays an immunoregulatory role in both the innate and adaptive immune systems. Rickets is a disorder that can develop due to a lack of vitamin D, calcium, or phosphate. Aim: The aim of this study was to assess serum immunoglobulins as one of the aspects of humoral immunity in children with vitamin D resistant rickets. Subjects and Methods: This casecontrol study was performed on 60 patients divided into Group (A):30 cases with vitamin D resistant rickets patients who were presented with rachitic manifestation who did not respond to therapeutic doses of the vitamin. Group (B):30 cases with untreated classic vitamin D deficiency rickets. Group (C): 30 healthy subjects as a control group. All subjects were subjected to detailed history taking including age, sex, weight, dietary history, medication history, and physical examination including vital signs, body weight, and head circumference. Laboratory investigations that included calcium, phosphorus, alkaline phosphatase, electrolytes, ESR, urine analysis, parathyroid hormone, vitamin D, and Immunoglobulin assay. Results: There is a significant decrease of IgA in vitamin D deficiency rickets and vitamin D resistant rickets than in controls (3.74 ± .867, 3.13 ± 1.72, 5.01 ± 1.61, respectively with P =0.012).There is a significant decrease of IgG in vitamin D deficiency rickets and a significant increase in vitamin D resistant rickets than in controls (523.5 ± 136.3, 751.25 ±163.5, 692.0 ± 186.4, respectively with P =0.009). There is no significant difference in IgM in the three studied groups. Conclusion: Patients with vitamin D deficiency have significantly lower IgG levels, while vitamin D resistant patients have significantly higher IgG levels. Whereas, both groups have lower IgA and normal IgM levels.

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Section: Discussionsupporting

confidence: 80%

Serum Immunoglobulins in Children with Vitamin D Resistant Rickets

Amin

Kamal

Gaballah³

et al. 2019

Suez Canal University Medical Journal

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“…[10,11] However, few studies have been reported concerning with vitamin D status in patients with primary immunodeficiency (PID). [12] This study aimed to investigate the relationship among clinical characteristics, frequency of infections, and seasonal serum vitamin D levels of patients with PID on regular intravenous immunoglobulin (IVIG) therapy.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency

Çetinkaya¹,

Ayvaz²,

Cüzdanci³

et al. 2019

Turk J Immunol

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Introduction: Vitamin D is a hormone responsible in the regulation of immune response. This study was designed to assess the relationship of vitamin D deficiency on the development of infections in patients with primary immunodeficiency (PID). Materials and Methods:A total of 39 patients (M/F: 23/16) and 39 age-and sex-matched healthy controls (M/F: 23/16) were enrolled in the study. We measured the frequency of infections and serum vitamin D levels in winter and summer seasons. Results:The median age of the patient and control groups were 15.0 (Interquartile range: 7.5-26.0) years and 14.0 (9.0-25.0) years, respectively (p=0.810). Winter and summer vitamin D levels were similar both in patient and control groups (p=0.492 for winter, p=0.503 for summer). Number of the patients with low serum vitamin D levels and with infections were higher in winter than in summer. Autoimmune and inflammatory diseases (AID) were predominantly observed in patients with low winter vitamin D levels and in common variable immunodeficiency (CVID) group. Patients with CVID had lower serum vitamin D levels both in summer (p=0.048) and in winter (p=0.008). Conclusions:In this study, we showed the seasonal variation of serum vitamin D in patients with PID. There was also increased frequency of CVID and AID in those patients with low vitamin D levels. In addition, vitamin D might be given in winter to the patients with PID to take infections and autoimmune disorders under control. ÖzGiriş: D vitamini, bağışıklık cevaplarının düzenlenmesinden sorumlu bir hormondur. Bu çalışma, D vitamini eksikliğinin primer immün yetersizliği olan hastalarda (PİY) enfeksiyon gelişimi ile ilişkisini değerlendirmek için tasarlanmıştır.Gereç ve Yöntemler: Çalışmaya toplam 39 hasta (E / K: 23/16) ve 39 yaş ve cinsiyet uyumlu sağlıklı kontrol grubu (E / K: 23/16) alındı. Kış ve yaz aylarında enfeksiyon sıklığı ve serum D vitamini düzeyleri saptandı.Bulgular: Hasta ve kontrol grubunun ortanca yaşı 15.0 (çeyrekler arası aralık: 7.5-26.0) ve 14.0 (9.0-25.0) idi (p = 0.810). Kış ve yaz D vitaminleri hem hasta hem de kontrol grubunda benzerdi (p=0.492 kış için, p0.503 yaz için). Serum D vitamini düzeyi düşük ve enfeksiyonu olan hastaların sayısı kışın yaz aylarında olduğundan daha fazla idi. Otoimmün ve enflamatuvar hastalıklar (OIH) ağırlıklı olarak, düşük kış D vitamini düzeyi olan hastalarda ve yaygın değişken immün yetersizlikli hastalık (YDİY) grubunda gözlemlendi. YDİY tanılı hastaların hem yaz (p=0.048) hem de kış (p=0.008) D vitamini düzeyleri düşüktü.Sonuç: Bu çalışmada PİY tanılı hastalarda serum D vitamini düzeylerinin mevsimsel değişimi gösterilmiştir. Düşük D vitamini düzeyleri olan hastalarda ayrıca YDİY ve OİH sıklığı artmıştır. Ek olarak, D vitamini, enfeksiyonları ve otoimmün hastalıkları kontrol altına almak için PID'li hastalara kışın verilebilir.Anahtar Kelimeler: Otoimmün hastalıklar, enfeksiyon, primer immün yetersizlik, D vitamini eksikliği

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