Vitamin D and psychosis: Mini meta-analysis

Murri, Martino Belvederi; Respino, Matteo; Masotti, Mattia; Innamorati, Marco; Mondelli, Valeria; Pariante, Carmine M.; Amore, Mario

doi:10.1016/j.schres.2013.07.017

Cited by 98 publications

(67 citation statements)

References 27 publications

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“…Furthermore, we found that VD deficiency could aggravate the antipsychotic-induced activation of the SREBP system, which can be partly restored by VD supplementation, suggesting that INSIG/SREBP pathway is involved in the beneficial effects of VD on lipid profile. These findings are significant since patients with psychosis are prone to have suboptimal VD status and co-prevalent metabolic syndrome during the chronic hospitalization and antipsychotic therapy (Belvederi Murri et al, 2013;Nousen et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that patients with psychotic disorders are prone to have deficient or insufficient vitamin D (VD) status (Belvederi Murri et al, 2013;Valipour et al, 2014) and concomitant metabolic syndrome during the chronic hospitalization and antipsychotic therapy. VD, which was traditionally associated with musculo-skeletal system, now is implicated as a pleiotropic secosteroid affecting multiple aspects of human physiology.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency exacerbates atypical antipsychotic-induced metabolic side effects in rats: Involvement of the INSIG/SREBP pathway

Dang¹,

Jiang²,

Cai³

et al. 2015

European Neuropsychopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency exacerbates atypical antipsychotic-induced metabolic side effects in rats: Involvement of the INSIG/SREBP pathway

Dang¹,

Jiang²,

Cai³

et al. 2015

European Neuropsychopharmacology

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“…Two recent meta-analyses have indicated significantly lower serum -25 hydroxy vitamin D (S-25 OH D) in patients with established psychiatric disorders compared to healthy controls (Belvederi Murri et al, 2013;Valipour et al, 2014), in line with previous studies showing an association between lower S-25 OH D and having a diagnosis in the schizophrenia spectrum (Rey-Sanchez et al, 2009;Partti et al, 2010). Correspondingly, in a study of diagnostically diverse psychiatric out-patients the lowest S-25 OH D levels were found in patients with schizophrenia or autism spectrum disorders (Humble et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.

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“…Itzhaky et al 17 found in their study that hypovitaminosis D is more prominent in schizophrenic patients compared to patients with depression. Moreover, in the meta-analysis of Belvederi Murri et al 28 and in the study of Schneider et al 13 , it was found that 25(OH)D levels between these two disorders were similar. The cause of this contradiction could be attributed to the small number of samples included in the study, and to the fact that vitamin D was considered deficient at different values, and to the existing geographic and cultural variability of the patients included.…”

Section: Cmjmentioning

confidence: 93%

Hypovitaminosis D according to psychiatric diagnosis groups: A study with control group

Mert¹

2016

Cumhuriyet Med J

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SUMMARYObjective: One of the risk factor for different psychiatric disorders has been indicated as hypovitaminosis D. The present study aimed to compare 25 (OH) D level between 4 different types of psychiatric disorders (schizophrenia, bipolar disorder, depression and anxiety disorder) and healthy controls, and to assess the risk factors of hypovitaminosis D in psychiatric inpatients. Method: This retrospective study included 974 individuals [depression (n=553), bipolar disorder (n=135), schizophrenia (n=186) and anxiety disorder (n=100)] who received inpatient treatment in psychiatry clinic between 2012 and 2014, and 574 individuals in control group who were not diagnosed with a psychiatric condition. A 25 (OH) D level less than 21 ng/mL was considered to indicate hypovitaminosis D. Results: 25 (OH) D level average of the control group was found to be significantly higher than that of the four psychiatric diagnosis groups (p<0.05). There was no significant difference among 25 (OH) D level of psychiatric diagnosis groups (p<0.05). Comparing 25 (OH) D level among age groups in each study group, it was found that 25 (OH) D level of schizophrenic patients with an age range of 35-54 was found to be significantly lower than that of schizophrenic patients with an age range of 18-34 (p<0.05). 25 (OH) D levels by genders were lower among women in all diagnosis groups (p<0.05), while they were similar for both genders in control group (p>0.05). Logistic regression analysis of the study parameters suggested that the female gender (odds ratio: 3.46; 95% confidence interval: 0.99-1.01), winter and spring seasons (odds ratio: 2.56; 95% confidence interval: 1.69-3.86 and odds ratio: 2.03; 95% confidence interval: 1.33-3.11, respectively) were significant predictors in level of vitamin D in psychiatric inpatients. Conclusions: Hypovitaminosis D is a condition that frequently exists in inpatients in psychiatry clinic suffering from schizophrenia, bipolar disorder, anxiety disorder and d epression. Being a female, winter and spring are the most remarkable risk factors in these patients. Keywords: Hypovitaminosis D, schizophrenia, bipolar disorder, depression, anxiety Sonuç: Psikiyatri kliniğinde yatarak tedavi gören şizofreni, bipolar bozukluk, anksiyete ve depresyon hastalarında vitamin D eksikliği sıklıkla görülen bir durumdur. Bu hastalarda kadın olma ve kış-ilkbahar mevsimleri vitamin D eksikliği için en önemli risk faktörleri olarak belirlenmiştir.

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Vitamin D and psychosis: Mini meta-analysis

Cited by 98 publications

References 27 publications

Vitamin D deficiency exacerbates atypical antipsychotic-induced metabolic side effects in rats: Involvement of the INSIG/SREBP pathway

Vitamin D deficiency exacerbates atypical antipsychotic-induced metabolic side effects in rats: Involvement of the INSIG/SREBP pathway

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Hypovitaminosis D according to psychiatric diagnosis groups: A study with control group

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