Vitamin D and the occurrence of depression: causal association or circumstantial evidence?

Bertone‐Johnson, Elizabeth R.

doi:10.1111/j.1753-4887.2009.00220.x

Cited by 211 publications

(166 citation statements)

References 64 publications

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“…Recent findings from a randomised trial suggest that high doses of supplemental vitamin D may improve mild depressive symptoms [59]. However, important questions persist concerning such issues as: 1) how does vitamin D affect monoamine function and hypothalamicpituitary-adrenal axis response to stress; 2) does vitamin D supplementation improve mood in individuals with moderate-to-severe depression; and 3) is vitamin D sufficiency protective against incidents of depression and recurrence.…”

Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Vitamin D. Vitamin D deficiency is associated with depression and psychosis in epidemiologic samples (Bertone-Johnson 2009;Berg et al 2010). Vitamin D is neuroprotective to hippocampal cells, regulating calcium ion channels and activating protein kinase C (PKC) and mitogen-activated protein kinase (maPK) pathways (McCann and Ames 2008).…”

Section: Effects On Inflammation and Relation To Mood Changesmentioning

confidence: 99%

Nutritional and Safety Outcomes from an Open-Label Micronutrient Intervention for Pediatric Bipolar Spectrum Disorders

Frazier

Gracious²,

Arnold³

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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Objective: The purpose of this study was to report the safety, tolerability, and serum micronutrient concentrations and their correlations with mood changes from an 8 week pilot feasibility study of a 36 ingredient multinutrient supplement, EMPowerplus (EMP+), for pediatric bipolar spectrum disorders (BPSD). Methods: Ten children ages 6-12 received EMP + escalating from one to four capsules t.i.d., with four children increased to the maximum suggested dose, five capsules t.i.d. Outcome measures were micronutrient concentrations in serum and red blood cells, vital signs, body mass index (BMI), dietary intake (Food Frequency Questionnaire and 24 hour dietary recall interview), and mood and global functioning ratings. Results: Seven children (70%) completed the study. Three (30%) terminated early for tolerability and compliance issues. Adverse effects were mild and transient, and chiefly consisted of initial insomnia or gastrointestinal (GI) upset. No differences occurred in BMI ( p = 0.310) or waist-hip ratio (WHR; p = 0.674) pre-to postsupplementation. Four of the tested serum vitamin concentrations increased from pre-to postsupplementation: vitamin A-retinol, vitamin B6, vitamin E-a-tocopherol; and folate (all p < 0.05). The increase in serum 25-OH vitamin D approached significance ( p = 0.063). No differences were found in dietary intake pre-to postsupplementation, suggesting that blood nutrient level increases were caused by EMP + . Conclusions:In this open prospective study, short-term use of EMP + in children with BPSD appeared safe and welltolerated, with a side effect profile preferable to first-line psychotropic drugs for pediatric bipolar spectrum disorders. A double-blind, randomized clinical trial is feasible, appears safe, and is warranted by open-label clinical outcomes and plausible mechanisms of action, combined with documentation of increased serum concentrations of specific micronutrients.

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“…Due to the research methodological limitation including study design, sample size, lack of control of confounding factors and other issues; it is difficult to confidently interpret a significant causal association vs. a circumstantial evidence between vitamin D level and occurrence of depression. 23 Nevertheless, majority of the studies support an association between low levels of vitamin D and depression.…”

Section: Epidemiologymentioning

confidence: 99%

Vitamin D for Depression with a Seasonal Pattern: an Effective Treatment Strategy

Sarkar¹

2017

IPMRJ

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Vitamin D and the occurrence of depression: causal association or circumstantial evidence?

Cited by 211 publications

References 64 publications

Application of fatty acid and lipid measurements in neuropsychiatry

Application of fatty acid and lipid measurements in neuropsychiatry

Nutritional and Safety Outcomes from an Open-Label Micronutrient Intervention for Pediatric Bipolar Spectrum Disorders

Vitamin D for Depression with a Seasonal Pattern: an Effective Treatment Strategy

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