Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

Patrick, Rhonda P.; Ames, Bruce N.

doi:10.1096/fj.14-268342

Cited by 403 publications

(266 citation statements)

References 224 publications

(255 reference statements)

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“…Similar experiments provided hints regarding the role of serotonin in maintaining the mental balance and avoiding depression [61], but none of these studies successfully dissected the exact relation. Recently, association of compounds such as vitamin D, 2 marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with serotonin release and control has been reported, confirming their indirect impact on mental disorders [62].…”

Section: Role Of Serotonin In Psycho-behavioural Manifestationmentioning

confidence: 98%

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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Structural changes in different regions of the brain have become clinically relevant and regarded as the signature phenomenon for neurological diseases. Morphological changes in brain are also associated with neuronal and neurochemical alterations. Studies have showed that minute changes in neurochemical levels may have marked impact on the psychobehaviour of the subject. Several neurological disease profiles have been reported with such specific psychobehavioural expression. However, application of behavioural abnormalities as possible disease progress markers has not been considered and emphasised much. Reports suggested that-the subjects, who have already entered into the terminal stage of the disease, used to show cardinal behavioural signs for a specific disease profile. However, psychological expressions are comparatively early expressive. As most of the neurodegenerative disorders are unidirectional and progressive by nature, therapeutic intervention at the right time is essential for attaining the desired outcome. Moreover, early diagnosis can aid in managing the disease progression also. Psychobehavioural analysis could meet the expected outcome of disease diagnosis if implemented properly and timely. In the present review, we have amalgamated the reported behavioural anomalies with the supportive background from neurochemical basis. Further, we have concluded that behaviour centric studies could be a potential diagnostic tool for the early diagnosis of major neurological diseases such as Alzheimer disease, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), Bipolar disorder, Schizophrenia, Impulse control disorder (ICD) and Obsessive-compulsive disorder (OCD).

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Section: Role Of Serotonin In Psycho-behavioural Manifestationmentioning

confidence: 98%

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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“…18,19 Ein af þeim tilgát-um sem settar hafa verið fram til að útskýra þessar niðurstöður er að D-vítamín gegni mikilvaegu hlutverki við myndun á taugaboð-efninu serótónín, sem meðal annars tekur þátt í ferlum tengdum félagsfaerni og vitsmunagetu. 20 Einkenni geðrofssjúkdóma geta meðal annars falið í sér skerta vitsmunagetu og tilhneigingu til að draga sig í hlé félagslega. Ómega-3 fitusýrur, sér í lagi eicosapentaenoic sýra (EPA) og docosahexaenoic sýra (DHA), hafa einnig verið tengdar við framleiðslu serótóníns.…”

Section: Umraeðaunclassified

“…Ómega-3 fitusýrur, sér í lagi eicosapentaenoic sýra (EPA) og docosahexaenoic sýra (DHA), hafa einnig verið tengdar við framleiðslu serótóníns. 20 Ávinningur af D-vítamín-og ómega-3 faeðubótargjöf fyrir sjúklinga með geðrofssjúkdóma hefur verið rannsakaður að undanförnu og benda niðurstöður til þess að faeðubót geti dregið úr einkennum sjúkdómsins. 20 Frekari rannsókna er þörf til að unnt sé að móta klínískar leiðbeiningar um notkun faeðubótarefna fyrir þennan hóp.…”

Section: Umraeðaunclassified

“…20 Ávinningur af D-vítamín-og ómega-3 faeðubótargjöf fyrir sjúklinga með geðrofssjúkdóma hefur verið rannsakaður að undanförnu og benda niðurstöður til þess að faeðubót geti dregið úr einkennum sjúkdómsins. 20 Frekari rannsókna er þörf til að unnt sé að móta klínískar leiðbeiningar um notkun faeðubótarefna fyrir þennan hóp. 20 Hins vegar er mikilvaegt að tryggja naega neyslu á D-vítamíni og ómega-3 fitusýr-um í faeði einstaklinga með geðrofssjúkdóma líkt og annarra hópa samfélagsins.…”

Section: Umraeðaunclassified

“…20 Frekari rannsókna er þörf til að unnt sé að móta klínískar leiðbeiningar um notkun faeðubótarefna fyrir þennan hóp. 20 Hins vegar er mikilvaegt að tryggja naega neyslu á D-vítamíni og ómega-3 fitusýr-um í faeði einstaklinga með geðrofssjúkdóma líkt og annarra hópa samfélagsins. Í ljósi niðurstaðna rannsóknar okkar maetti faera rök fyrir því að ráðleggja þyrfti faeðubót sem gefur D-vítamín og ómega-3 fitusýrur fyrir ungt fólk með geðrofssjúkdóma á Íslandi, takist ekki að auka neyslu á feitum fiski, sem er góð uppspretta þessara efna, með einhverjum leiðum.…”

Section: Umraeðaunclassified

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Fæðuval ungra Íslendinga með geðrofssjúkdóma og þróun líkamsþyngdar þeirra á 8 til 12 mánaða tímabili

Fridthjofsdottir¹,

Geirsdóttir²,

Jónsdóttir³

et al. 2017

LBL

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Dietary Lipids and Health

Morzelle¹,

Watkins²,

Li³

et al. 2020

Bailey's Industrial Oil and Fat Products

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Lipids are essential components of living organisms and support multiple biological and physiological functions in the human body. They serve as the structural building material of all membranes of cells and organelles. Lipids and their derivatives also serve as signaling molecules that facilitate a variety of physiological functions. In addition, lipids are recognized as important biomarkers of disease and are involved in several pathological conditions. Individual fatty acids can influence biological processes, such as membrane‐associated receptors and signal transduction systems, and ion channels. Recent literature also demonstrates a specific role of fatty acids in gene modulation and protein expression to influence risk of chronic disease. Polyunsaturated fatty acids (PUFAs) are the focus of substantial research interest in this area mainly because of their ability to be converted to various bioactive regulatory molecules, such as prostaglandins, leukotrienes, and thromboxanes. Arachidonic acid (AA, 20:4n‐6) and eicosapentaenoic acid (EPA, 20:5n‐3) are two major players in the regulation and production of these bioactive molecules. In addition, an absolute requirement of docosahexaenoic acid (DHA) is necessary for normal neural and retinal development in the infant and young child. Besides the study of these PUFA molecules, numerous animal and human studies also suggest that other dietary lipids, such as cholesterol and saturated fatty acids, increase serum cholesterol as well as LDL‐cholesterol concentrations. In summary, this article provides a contemporary understanding of food lipids in nutrition and health, especially the underlying cellular and molecular mechanisms of the actions of these bioactive dietary lipids.

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Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

Cited by 403 publications

References 224 publications

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Fæðuval ungra Íslendinga með geðrofssjúkdóma og þróun líkamsþyngdar þeirra á 8 til 12 mánaða tímabili

Dietary Lipids and Health

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