Vitamin D concentrations and COVID-19 infection in UK Biobank

Hastie, Claire E.; Mackay, Daniel; Ho, Frederick K.; Celis‐Morales, Carlos; Katikireddi, Srinivasa Vittal; Niedzwiedz, Claire L.; Jani, Bhautesh; Welsh, Paul; Mair, Frances S; Gray, Stuart R.; O’Donnell, Catherine; Gill, Jason M.R.; Sattar, Naveed; Pell, Jill P.

doi:10.1016/j.dsx.2020.04.050

Cited by 422 publications

(525 citation statements)

References 19 publications

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“…Our findings about the increased risk of testing positive for COVID-19 with likely deficient vitamin D status compared with likely sufficient vitamin D status contrasts with the findings of a recent study by Hastie et al 33 That article examined the association between vitamin D deficiency and testing positive for COVID-19 within the UK Biobank and did not find a statistically significant association. However, the vitamin D levels studied were between 10 and 14 years before the COVID-19 diagnosis, and the analysis did not control for treatment after the levels were assessed.…”

Section: Discussioncontrasting

confidence: 99%

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

et al. 2020

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Key Points Question Is vitamin D status, reflecting vitamin D levels and treatment, associated with test results for coronavirus disease 2019 (COVID-19)? Findings In this cohort study of 489 patients who had a vitamin D level measured in the year before COVID-19 testing, the relative risk of testing positive for COVID-19 was 1.77 times greater for patients with likely deficient vitamin D status compared with patients with likely sufficient vitamin D status, a difference that was statistically significant. Meaning These findings appear to support a role of vitamin D status in COVID-19 risk; randomized clinical trials are needed to determine whether broad population interventions and interventions among groups at increased risk of vitamin D deficiency and COVID-19 could reduce COVID-19 incidence.

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Section: Discussioncontrasting

confidence: 99%

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

et al. 2020

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“…An observational study based on the UK Biobank data claimed that no link between vitamin D concentrations and risk of COVID-19 infection either overall or separated ethnic groups (16). However, one study used causal inference analysis, supported the hypothesis that vitamin D plays a causal role in COVID-19 outcomes via modi cation of host responses to SARS-CoV-2 (24).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, numerous population-based studies have evaluated the Vitamin D de ciency in COVID-19 patients relative to controls; however, the ndings have been inconsistent. Some studies showed that COVID-19 patients had a lower 25 hydroxyvitamin D (25OHD) concentration compared with healthy controls (8,(11)(12)(13), while others found no association (14)(15)(16). The inconsistent ndings from these epidemiological studies may be due to differences in the study design, study population, assays used for measuring Vitamin D de ciency.…”

mentioning

confidence: 99%

Association of 25 Hydroxyvitamin D Concentration with Risk of COVID-19: A Mendelian Randomization Study

Liu

Tian

Zhang

et al. 2020

Preprint

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Background: Coronavirus disease 2019 (COVID-19) has caused a large global pandemic. In observational studies, 25 hydroxyvitamin D (25OHD) concentration has been associated with an increased risk of Coronavirus disease 2019 (COVID-19). However, it remains unclear whether this association is causal.Methods: We performed a two-sample Mendelian randomization (MR) to explore the causal relationship between 25OHD concentration and COVID-19, using summary data from the genome-wide association studies (GWASs) and using 25OHD concentration-related SNPs as instrumental variables (IVs). Results: MR analysis did not show any evidence of a causal association of 25OHD concentration with COVID-19 susceptibility and severity (odds ratio [OR]=1.136, 95% confidence interval [CI] 0.988-1.306, P=0.074; OR=0.889, 95% CI 0.549-1.439, P=0.632). Sensitivity analyses using different instruments and statistical models yielded similar findings, suggesting the robustness of the causal association. No obvious pleiotropy bias and heterogeneity were observed.Conclusions: The MR analysis showed that there might be no linear causal relationship of 25OHD concentration with COVID-19 susceptibility and severity.

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“…A correlation between vitamin D levels and risk of COVID-19 has not been established to date. 75 However, in other infectious diseases, supplementation has been shown to be beneficial. 76 Thus, we marginally support appropriate vitamin D supplementation (CIII).…”

Section: Preventionmentioning

confidence: 99%

Evidence-based management of COVID-19 in cancer patients: Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)

Giesen

Sprute²,

Rüthrich

et al. 2020

European Journal of Cancer

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Since its first detection in China in late 2019 the novel coronavirus SARS-CoV-2 and the associated infectious disease COVID-19 continue to have a major impact on global health care and clinical practice. Cancer patients, in particular those with haematological malignancies, seem to be at an increased risk for a severe course of infection. Deliberations to avoid or defer potentially immunosuppressive therapies in these patients need to be balanced against the overarching goal of providing optimal antineoplastic treatment. This poses a unique challenge to treating physicians. This guideline provides evidence-based recommendations regarding prevention, diagnostics and treatment of SARS-CoV-2 infection and COVID-19 as well as strategies towards safe antineoplastic care during the COVID-19 pandemic. It was prepared by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) by critically reviewing the currently available data on SARS-CoV-2 and COVID-19 in cancer patients applying evidence-based medicine criteria.

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Vitamin D concentrations and COVID-19 infection in UK Biobank

Cited by 422 publications

References 19 publications

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

Association of 25 Hydroxyvitamin D Concentration with Risk of COVID-19: A Mendelian Randomization Study

Evidence-based management of COVID-19 in cancer patients: Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)

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