Vitamin D Decreases Respiratory Syncytial Virus Induction of NF-κB–Linked Chemokines and Cytokines in Airway Epithelium While Maintaining the Antiviral State

Hansdóttir, Sif; Monick, Martha M.; Lovan, Nina; Powers, Linda S.; Gerke, Alicia K.; Hunninghake, Gary W.

doi:10.4049/jimmunol.0902840

Cited by 307 publications

(315 citation statements)

References 82 publications

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“…Though more investigation is needed, basic research suggests that vitamin D may be important in viral defense, 165,166 reduction of virally induced airway inflammation, 167 and response to steroid therapy. [168][169][170] Cross-sectional data in children suggest a significant negative association between 25(OH)D and asthma symptoms, 171,172 and a significant positive association between 25(OH)D and both lung function and steroid response.…”

Section: Vitamin Dmentioning

confidence: 99%

Obesity, Nutrition, and Asthma in Children

Lang

2012

Pediatric Allergy, Immunology, and Pulmonology

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Section: Vitamin Dmentioning

confidence: 99%

Obesity, Nutrition, and Asthma in Children

Lang

2012

Pediatric Allergy, Immunology, and Pulmonology

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“…[25][26][27][28][29] Specific binding sites for 1,25(OH)2D3 localized to type II pneumocytes have been found in fetal rat lungs and it has been shown that vitamin D accelerates type II pneumocyte maturation, increases the surfactant synthesis and secretion and has a critical role in epithelialmesenchymal interaction during lung growth. 17,18 In probable pathophysiology of TTN, immaturity of epithelial sodium channels (ENaC) is now believed to be major factor in failure of lung fluid resorption.…”

Section: Discussionmentioning

confidence: 99%

Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

Singh

Sood

Narang

et al. 2017

Int J Contemp Pediatr

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Background: Transient tachypnea of newborn (TTN) is a common cause of respiratory distress in newborns with estimated incidence of 1-2% of all newborns. Although a self-limiting transient condition but it may cause severe morbidities. This study was conducted to find association of serum vitamin D levels in neonates who develop TTN as compared to normal healthy neonates.Methods: With thorough history with structured questionnaire and lab tests, serum vitamin D levels of 45 neonates who develop TTN were compared with 56 healthy neonates in control group.Results: Out of 45 neonates who develop TTN 39(86.7%) were deficient in vitamin D as compared to control group where 33(58.9%) out of 56 healthy neonates were deficient in vitamin D.Conclusions: Lower vitamin D levels at birth in term neonates is associated with increased risk of developing TTN and vitamin D may have a role in its pathogenesis.

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“…In their study, levels of mRNA of NF-KB related proinflammatory genes, tumor necrosis factor-a (TNF-o:), and MIF changed significantly during weight gain or weight loss periods (3). Besides, there is evidence that vitamin D induces Ikappa B alpha, an NF-kappaB inhibitor, in cells from certain different lineages (29). It could therefore be deduced that different levels of NF-KB in obese and lean subjects played a role in our study as the underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

MIF Expression in Induced Peripheral Blood Mononuclear Cells by Vitamin D3 and its Potential Correlation with Resting Metabolic Rate in Obesity

et al. 2011

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Macrophage migration inhibitory factor (MIF) plays a pivotal role in systemic and local inflammatory and immune responses. The aim of this study is to assess MIF gene expression in PBMCs harvested from obese individuals and to compare it with that of lean subjects to analyze any potential relationship between resting metabolic rate as well as several different parameters and MIF expression in PBMC. We also aim to assess anti-inflammatory characteristics of vitamin D 3 on MIF expression in vitro. Participants were 30 obese and 18 non-obese subjects who were assessed following an overnight fasting for RMR by means of indirect calorimetry. Body composition was measured using a Bodystat device. The PBMCs were separated from whole blood by the Ficoll-hypaque technique. The mRNA was extracted and the cDNA was synthesized. This process was followed by real-time PCR using primer pairs specific for MIF mRNA and beta actin as internal control. Our findings clearly demonstrate that there were significant differences in terms of BMI, BMR predict, fat proportion, fat mass, free fat mass, TBW, visceral fat, fasting serum glucose, TG, HDL, Hs-CRP and RMR between the two groups. Moreover, the level of MIF expression in the obese group was approximately 2.5 times higher compared to the lean group. An increased level of MIF expression in the obese group and a decreased expression of that non-obese was observed after inducing PBMCs with vitamin D3. One of the intriguing results of this study was the observed reverse correlation between MIF expression and fat mass as well as fat proportion after PBMCs were cultured in the presence of vitamin D 3• Therefore, it could be concluded that MIF expression, which is in turn influenced by vitamin D 3 , has a role in the hyperactive immune profile and the pro-inflammatory state observed in obese individuals which is suggested to have a causal relationship with obesity.

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Vitamin D Decreases Respiratory Syncytial Virus Induction of NF-κB–Linked Chemokines and Cytokines in Airway Epithelium While Maintaining the Antiviral State

Cited by 307 publications

References 82 publications

Obesity, Nutrition, and Asthma in Children

Obesity, Nutrition, and Asthma in Children

Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

MIF Expression in Induced Peripheral Blood Mononuclear Cells by Vitamin D3 and its Potential Correlation with Resting Metabolic Rate in Obesity

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