Vitamin D: Defense Against Delirium?

Pungsornruk, Karla; Fedorko, L.; Djaiani, George

doi:10.1053/j.jvca.2020.03.034

Cited by 1 publication

(4 citation statements)

References 15 publications

(34 reference statements)

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“…It is already known that the vitamin D receptor can be found in nearly all regions of the brain (cortex, hippocampus, and hypothalamus, among others). Vitamin D can upregulate the expression of vitamin D receptors, thereby having neuroprotective effects against glutamate toxicity and reducing the production of oxidative stress [ 5 ]. 3.…”

Section: Discussionmentioning

confidence: 99%

“…3. Vitamin D can influence the genetic expression of delirium-related neurotransmitters such as acetylcholine, serotonin, dopamine, and aminobutyric acid within the neural brain [ 5 ]. From the genetic level, Bowman et al validated the relationship between vitamin D levels and delirium, showing that correcting low levels of vitamin D is necessary to prevent the occurrence of delirium [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Omega-3 polyunsaturated fatty acids, like vitamins and minerals, are essential for the human body and have anti-inflammatory and vasodilatory properties, which may protect blood vessels and maintain blood perfusion in the brain. Meanwhile, there is increasing evidence suggesting that vitamin D deficiency may have an association with delirium [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Its role in calcium homeostasis and bone has been extensively studied. Of course, there are also some studies showing some effects of vitamin D on cognition and delirium [ 5 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

Miao

et al. 2023

PLoS ONE

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Background Now the occurrence of delirium is more concerning to clinicians and psychiatrists. It has been reported that vitamin D deficiency may be a relevant factor in the development of delirium in hospitalized patients. Study objective To investigate the association between vitamin D concentration and delirium in hospitalized patients. Design Meta-analysis. Methods A systematic literature search was conducted using PubMed, EMBASE, and the Cochrane Library. The primary outcome was the occurrence of delirium in the inpatient setting. Odds ratios (OR) were calculated with random or fixed effects models. Results In this article, we define the normal range of vitamin D concentrations as greater than 75 nmol / L, 50–75 nmol / L as vitamin D insufficiency, 25–50 nmol / L as vitamin D deficiency, and less than 25 nmol / L as vitamin D severe deficiency. The Results showed that severe vitamin D deficiency (OR: 1.98 [1.41–2.79], P<0.001) and vitamin D deficiency (OR: 1.50 [1.12–2.00], P = 0.006) were more likely to develop delirium than normal vitamin D levels. Subgroup analysis also revealed that low vitamin D concentrations were associated with a higher incidence of delirium, whether the cutoff point was 25 nmol/L (OR: 1.52 [1.40–1.64], P<0.001), 50 nmol/L (OR: 1.47 [1.19–1.82], P<0.001), or 75 nmol/L (OR: 1.54 [1.21–1.96], P<0.001). The included studies scored medium and high on the Newcastle-Ottawa quality assessment scale. Conclusion Compared with normal vitamin D levels, severe vitamin D deficiency and vitamin D deficiency, but not vitamin D insufficiency, are associated with a higher incidence of delirium in hospitalized patients. Trial registration This review was registered in the PROSPERO database under identifier CRD42021271347. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271347.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Its role in calcium homeostasis and bone has been extensively studied. Of course, there are also some studies showing some effects of vitamin D on cognition and delirium [ 5 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

Miao

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

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Vitamin D: Defense Against Delirium?

Cited by 1 publication

References 15 publications

Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

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