Vitamin D deficiency – a possible link between osteoporosis and metabolic syndrome

Brázdilová, Kristína; Dlesk, Andrea; Koller, Tomas; Killinger, Zdenko; J, Payer

doi:10.4149/bll_2012_093

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…Apart from the relation of a low serum level of 25-OHD to greater bone turnover, bone loss and OS, it is in an inverse association with BMI [ 4 , 19 , 20 ]. It has been calculated in multivariate analysis that a decrease of 0.74 nmol/l in 25-OHD causes an increase in BMI [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between 25-Hydroxyvitamin D and Newly Diagnosed Type 2 Diabetes Mellitus in Postmenopausal Women with Osteoporosis

Vujosevic

Borozan²,

Radojević³

et al. 2014

Med Princ Pract

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Objective: The aim of the study was to determine a correlation between the level of 25-hydroxivitamin D (25-OHD) and the incidence of diabetes. Subjects and Methods: In this prospective observational study, 97 (out of an initial 100) Caucasian women with osteoporosis (OS) were monitored for 2 years for the incidence of diabetes. Logistic regression analysis was used to establish an association with and prognostic value of vitamin D for the onset of type 2 diabetes mellitus, as well as insulin resistance, body mass index (BMI), total cholesterol and triglyceride levels in the development of diabetes. The serum level of 25-OHD was measured using immunochemiluminescence in March and April 2011. Results: Of the 97 patients (mean age 51.64 ± 5.86 years, range 36.0-73.0), 21 (21.65%) were diagnosed with diabetes during the observational period. The study showed that the 22 patients with low levels of vitamin D were more susceptible to diabetes (odds ratio = 0.958). The cut-off value of vitamin D using a receiver operating characteristic curve was 62.36 nmol/l with a sensitivity of 39.5% and a specificity of 90.5%. With an increase in BMI and triglyceride levels, women were, respectively, 1,591 and 2,821 times more likely to get diabetes than those without an increase. Conclusion: This study showed that the patients with postmenopausal OS and hypovitaminosis D, besides a high BMI, elevated triglyceride levels and insulin resistance, had an increased risk of developing type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Relationship between 25-Hydroxyvitamin D and Newly Diagnosed Type 2 Diabetes Mellitus in Postmenopausal Women with Osteoporosis

Vujosevic

Borozan²,

Radojević³

et al. 2014

Med Princ Pract

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“…Vitamin D deficiency results in bone loss and increased inflammation through its immunomodulatory effects. [ 12 13 14 ] Recent data suggested that Vitamin D deficiency may play a role both in periodontal disease and DM. [ 14 15 16 ]…”

Section: Introductionmentioning

confidence: 99%

Low levels of serum Vitamin D in chronic periodontitis patients with type 2 diabetes mellitus: A hospital-based cross-sectional clinical study

Joseph¹,

Nagrale²,

Joseraj³

et al. 2015

J Indian Soc Periodontol

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Aim:Vitamin D is associated with inflammatory diseases such as periodontal disease and diabetes mellitus (DM). The aim of our study was to find out the level of serum Vitamin D in chronic periodontitis patients (CHP) with and without type 2 DM.Materials and Methods:This study consists of 141 subjects, including 48 controls. Case groups consisted of 43 chronic periodontitis patients with type 2 DM (CHPDM) and 50 CHP. pocket depth (PD), clinical attachment loss (CAL), modified gingival index (MGI), plaque index (PI), and calculus index (CI) were taken. Serum 25-hydroxyvitamin D (25[OH] D) level in ηg/ml was estimated by electrochemiluminescence immunoassay with Elecsys and cobase e immunoassay analysers(cobase e 411). Other laboratory investigations including fasting blood sugar (FBS) and serum calcium were measured in all subjects.Results:The mean serum 25(OH) D level was 22.32 ± 5.76 ηg/ml, 14.06 ± 4.57 ηg/ml and 16.94 ± 5.58 ηg/ml for control, CHPDM and CHP groups respectively. The difference was statistically significant (P < 0.05). The mean value of FBS was significantly high in CHPDM group as compared to CHP group. Periodontal parameters like MGI, PI, PD, and CI showed significant difference between groups (P < 0.05) and higher score was found in CHP group, while CAL and PI showed no statistically significant difference between CHP and CHPDM group (P > 0.05).Conclusions:This study observed a low level of serum Vitamin D level in patients with CHP and CHPDM. Low Vitamin D level was observed in case groups may be due to the diseases process rather than low Vitamin D acting as a cause for the disease.

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“…Nonhereditary factors include alteration of hormone levels, aging, and increased oxidative stress . 1,25‐Dihydroxyvitamin D [1,25(OH) 2 D] is an important factor for optimal bone health . Vitamin D, synthesized in skin tissue or absorbed via the intestine, is first metabolized by the action of liver 25‐hydroxylase, to 25‐hydroxyvitamin D [25(OH)D], which is then converted, by the action of renal 1α‐hydroxylase (encoded by Cyp27b1 ), or of extrarenal Cyp27b1 to active 1,25(OH) 2 D. This moiety then exerts its action by binding to the vitamin D receptor (VDR) .…”

Section: Introductionmentioning

confidence: 99%

“…(2) 1,25-Dihydroxyvitamin D [1,25(OH) 2 D] is an important factor for optimal bone health. (3) Vitamin D, synthesized in skin tissue or absorbed via the intestine, is first metabolized by the action of liver 25-hydroxylase, to 25-hydroxyvitamin D [25(OH)D], which is then converted, by the action of renal 1α-hydroxylase (encoded by Cyp27b1), or of extrarenal Cyp27b1 (4,5) to active 1,25(OH) 2 D. This moiety then exerts its action by binding to the vitamin D receptor (VDR). (6,7) Our previous studies, using double homozygous knockout of Cyp27b1 and the parathyroid hormone gene (Pth) or double homozygous knockout of Cyp27b1 and the calcium sensitive receptor gene (Casr), demonstrated that endogenous and exogenous 1,25(OH) 2 D could directly stimulate osteoblastic bone formation via the VDR.…”

Section: Introductionmentioning

confidence: 99%

The Polycomb Protein Bmi1 Plays a Crucial Role in the Prevention of 1,25(OH)2D Deficiency-Induced Bone Loss

Sun

Qiao

Cui

et al. 2019

Journal of Bone and Mineral Research

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We analyzed the skeletal phenotypes of heterozygous null Cyp27b1 (Cyp27b1+/−) mice and their wild‐type (WT) littermates to determine whether haploinsufficiency of Cyp27b1 accelerated bone loss, and to examine potential mechanisms of such loss. We found that serum 1,25‐dihydroxyvitamin D [1,25(OH)2D] levels were significantly decreased in aging Cyp27b1+/− mice, which displayed an osteoporotic phenotype. This was accompanied by a reduction of expression of the B lymphoma Moloney murine leukemia virus (Mo‐MLV) insertion region 1 (Bmi1) at both gene and protein levels. Using chromatin immunoprecipitation (ChIP)‐PCR, electrophoretic mobility shift assay (EMSA) and a luciferase reporter assay, we then showed that 1,25(OH)2D3 upregulated Bmi1 expression at a transcriptional level via the vitamin D receptor (VDR). To determine whether Bmi1 overexpression in mesenchymal stem cells (MSCs) could correct bone loss induced by 1,25(OH)2D deficiency, we overexpressed Bmi1 in MSCs using Prx1‐driven Bmi1 transgenic mice (Bmi1Tg) mice. We then compared the bone phenotypes of Bmi1Tg mice on a Cyp27b1+/− background, with those of Cyp27b1+/− mice and with those of WT mice, all at 8 months of age. We found that overexpression of Bmi1 in MSCs corrected the bone phenotype of Cyp27b1+/− mice by increasing osteoblastic bone formation, reducing osteoclastic bone resorption, increasing bone volume, and increasing bone mineral density. Bmi1 overexpression in MSCs also corrected 1,25(OH)2D deficiency‐induced oxidative stress and DNA damage, and cellular senescence of Cyp27b1+/− mice by reducing levels of reactive oxygen species (ROS), elevating serum total superoxide dismutase levels, reducing the percentage of γH2A.X, p16, IL‐1β, and TNF‐α–positive cells and decreasing γH2A.X, p16, p19, p53, p21, IL‐1β, and IL‐6 expression levels. Furthermore, 1,25(OH)2D stimulated the osteogenic differentiation of MSCs, both ex vivo and in vitro, from WT mice but not from Bmi1−/− mice and 1,25(OH)2D administration in vivo increased osteoblastic bone formation in WT, but not in Bmi1 −/− mice. Our results indicate that Bmi1, a key downstream target of 1,25(OH)2D, plays a crucial role in preventing bone loss induced by 1,25(OH)2D deficiency. © 2019 American Society for Bone and Mineral Research.

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Vitamin D deficiency – a possible link between osteoporosis and metabolic syndrome

Cited by 8 publications

References 18 publications

Relationship between 25-Hydroxyvitamin D and Newly Diagnosed Type 2 Diabetes Mellitus in Postmenopausal Women with Osteoporosis

Relationship between 25-Hydroxyvitamin D and Newly Diagnosed Type 2 Diabetes Mellitus in Postmenopausal Women with Osteoporosis

Low levels of serum Vitamin D in chronic periodontitis patients with type 2 diabetes mellitus: A hospital-based cross-sectional clinical study

The Polycomb Protein Bmi1 Plays a Crucial Role in the Prevention of 1,25(OH)2D Deficiency-Induced Bone Loss

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