Vitamin D Deficiency Adds an Element of Risk to Insulin Resistance in Colorectal Neoplasms

Abstract

IR increases the risk of CRNs, and a combination of IR and VitDdef further increases this risk. As both VitDdef and IR are modifiable risk factors, such associations may have important clinical implications in the prevention of CRNs.

Effect of serum 25-hydroxyvitamin D level on lung, breast, colorectal and prostate cancers: a nested case-control study

“…In a nested casecontrol study from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, colorectal cancer risk was significantly lower in the highest vitamin D quintile compared with the lowest quintile (11). In contrast, vitamin D level had no significant effect on colorectal cancer risk in a 2011 case-control study conducted in the USA (13) nor in a 2015 cross-sectional study conducted in South Korea (14). Similar results were obtained in our study, however, the sample size was too low to detect a small effect.…”

“…Evidence linking vitamin D deficiency with increased cancer risk and mortality has been found in studies conducted over the last 20-30 years (2,4). Although epidemiologic studies indicate that vitamin D levels are inversely associated with colorectal cancer (5)(6)(7)(8)(9)(10)(11)(12), several studies found inconsistent results for this association (13,14). The findings of epidemiologic studies investigating the relationship between vitamin D and breast cancer have been inconsistent.…”