Vitamin D deficiency among pediatric osteoarticular tuberculosis patients

Dabla, Pradeep Kumar; Agarwal, Anil; Mishra, Madhusudan; Sharma, Savita

doi:10.1016/j.jcot.2016.10.006

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…An observational study conducted to assess the serum concentration of 25(OH)D among children with active tuberculosis (TB) using non-TB pneumonia and healthy controls revealed that larger number of vitamin D deficient children were from active TB group [ 9 ]. Similarly, many studies conducted elsewhere [ [10] , [11] , [12] , [13] , [14] ] delineated similar findings including Dabla's study conducted among pediatric osteoarticular tuberculosis patients which revealed that 56% of active TB cases were vitamin D deficient and had lower levels of serum 25(OH)D compared to healthy controls [ 11 ]. However, significant number of studies found no significant difference in vitamin D deficiency status TB patients and healthy children [ [15] , [16] , [17] ].…”

Section: Introductionsupporting

confidence: 56%

“…Different studies among under five children shows that decreased level of 25(OH)D were more prevalent among under five children with respiratory tract infections (RTIs) and its deficiency was associated with increased risk of RTIs [ [8] , [9] , [10] ]. Furthermore, studies also shows that, normal to high serum 25(OH)D status appears to have some beneficial influence on the incidence and severity of some, though not all, types of infections [ [10] , [11] , [12] ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

Shaka

Kabthymer

Meshesha

et al. 2022

Annals of Medicine &Amp; Surgery

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Section: Introductionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

Shaka

Kabthymer

Meshesha

et al. 2022

Annals of Medicine &Amp; Surgery

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“…This is in contrast to prior studies that have reported articular involvement predominantly in the context of immunosuppression (Pigrau-Serrallach 2013, Calle 2018, Hodkinson 2009). Vitamin D deficiency has been associated with the osteoarticular TB, predominantly among paediatric patients (Dabla 2016).…”

Section: Discussionmentioning

confidence: 99%

Extraspinal articular tuberculosis: An 11-year retrospective study of demographic features and clinical outcomes in East London

McGuire

Rajagopal

Vaikunthanathan

et al. 2020

Journal of Infection

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The global incidence of tuberculosis (TB) infection was estimated by the WHO to be 10 million cases in 2018, 85% of whom had pulmonary TB (pTB) infection (WHO 2019). In Europe, the extrapulmonary TB (EPTB) incidence is increasing, accounting for 22.6% of new cases reported in 2017 (ECDC 2019). Furthermore, the incidence of articular TB infections has risen in Europe (Jutte 2004, Lesic 2010. This is reflected in UK surveillance data, where in 2017, 2.2% of new TB cases presented with non-spinal bone infections (Kruijshaar 2009, PHE 2018. Globally, this rise in EPTB infections has largely been ascribed to a growing population of immunosuppressed patients including those on long-term steroids and biologic therapies, as well as to an ageing population (Pigrau-Serrallach 2013, Byng-Maddick 2016). However, in low-incidence countries in Europe the rise in articular TB infections has also been attributed to increasing rates of migration (Jutte 2004, Krujishaar 2009. EPTB infection is thought to occur through haematogenous, contiguous or lymphatic spread in the primary infection stage, when mycobacteria can spread to any organ or tissue and remain dormant for years. Articular infection most commonly affects weight-bearing large joints such as the spine, knees and hips. Infection is often slowly progressing with joint effusions and pain, progressing to the formation of sinus tracts and eventually to complete joint destruction (Hogan 2017). Initial symptoms are vague and may mimic other conditions such as bacterial osteoarticular infection. This can result in significant diagnostic delay, especially in settings where TB is non-endemic and clinical suspicion is low (Erdem 2005, Broderick 2018). Most studies describing osteoarticular TB have focused on paediatric populations or on spinal TB with only a few published case series of extra-

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“…In India, three studies investigated serum 25(OH)D concentrations in children with osteoarticular TB [37,38] and intrathoracic TB [39]. Agarwal's study revealed hypovitaminosis D in 86% of patients while not discovering any discernible difference in 25(OH)D levels with respect to sex, age, or site of infection.…”

Section: Vitamin D and Tuberculosismentioning

confidence: 99%

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

2019

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Purpose Respiratory tract infections (RTIs) are a major cause of illness worldwide and the most common cause of hospitalization for pneumonia and bronchiolitis. These two diseases are the leading causes of morbidity and mortality among children under 5 years of age. Vitamin D is believed to have immunomodulatory effects on the innate and adaptive immune systems by modulating the expression of antimicrobial peptides, like cathelicidin, in response to both viral and bacterial stimuli. The aim of this review is to summarize the more recently published data with regard to potential associations of 25-hydroxyvitamin D [25(OH)D] with infectious respiratory tract diseases of childhood and the possible health benefits from vitamin D supplementation. Methods The literature search was conducted by using the PubMed, Scopus, and Google Scholar databases, with the following keywords: vitamin D, respiratory tract infection, tuberculosis, influenza, infancy, and childhood. Results Several studies have identified links between inadequate 25(OH)D concentrations and the development of upper or lower respiratory tract infections in infants and young children. Some of them also suggest that intervention with vitamin D supplements could decrease both child morbidity and mortality from such causes. Conclusions Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses.

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Vitamin D deficiency among pediatric osteoarticular tuberculosis patients

Abstract: The osteoarticular tuberculosis cases had low serum vitamin D levels compared to healthy controls. The low vitamin D levels were persistent irrespective of gender and age in osteoarticular tuberculosis children. There was widespread vitamin D insufficiency in apparently healthy controls.

Cited by 6 publications

References 11 publications

Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

Extraspinal articular tuberculosis: An 11-year retrospective study of demographic features and clinical outcomes in East London

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

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