Vitamin D deficiency and cardiovascular pathology

Подзолков, В. И.; Pokrovskaya, A. E.; Панасенко, О. І.

doi:10.26442/terarkh2018909144-150

Cited by 20 publications

(14 citation statements)

References 43 publications

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“…Vitamin D is a group of organic chemical compounds belonging to the group secosteroids, among which calcitriol (1,25-dihydroxycholecalciferol) performs the highest biological (hormonal) activity [26,141]. Vitamin D is currently at the center of research interest for many scientists due to its widespread deficiency, reaching about 30-50% on a global scale, especially in older age groups [19,142]. Many scientists have been involved in the research on the discovery and description of vitamin D properties.…”

Section: Vitamin D-function and Antioxidant Effectmentioning

confidence: 99%

“…Recently, attention has been paid to radioprotective properties of two hormones, whose synthesis depends on the specific light wavelengths, namely melatonin and vitamin D [ 17 , 18 ]. Both substances are endogenous compounds, but their deficiencies have been widely described in modern societies [ 19 , 20 ]. Melatonin as a strong direct and indirect antioxidant has been considered a radioprotector since the beginning of the 21st century [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D

Nuszkiewicz

Woźniak

Szewczyk-Golec

2020

IJMS

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Ionizing radiation (IR) has found widespread application in modern medicine, including medical imaging and radiotherapy. As a result, both patients and healthcare professionals are exposed to various IR doses. To minimize the negative side effects of radiation associated with oxidative imbalance, antioxidant therapy has been considered. In this review, studies on the effects of melatonin and vitamin D on radiation-induced oxidative stress are discussed. According to the research data, both substances meet the conditions for use as agents that protect humans against IR-induced tissue damage. Numerous studies have confirmed that melatonin, a hydro- and lipophilic hormone with strong antioxidant properties, can potentially be used as a radioprotectant in humans. Less is known about the radioprotective effects of vitamin D, but the results to date have been promising. Deficiencies in melatonin and vitamin D are common in modern societies and may contribute to the severity of adverse side effects of medical IR exposure. Hence, supporting supplementation with both substances seems to be of first importance. Interestingly, both melatonin and vitamin D have been found to selectively radiosensitise cancer cells, which makes them promising adjuvants in radiotherapy. More research is needed in this area, especially in humans.

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Section: Vitamin D-function and Antioxidant Effectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D

Nuszkiewicz

Woźniak

Szewczyk-Golec

2020

IJMS

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“…Low bone mass has been reported to be related to cardiovascular diseases 5 . It has been found that osteoporosis and HF share common risk factors, such as advanced age, vitamin D deficiency, renal disease and other comorbidities 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of the risk of incident heart failure in osteoporosis patients: a systematic review and meta-analysis of eligible cohort studies

Gu¹,

Yang²,

Zhang³

et al. 2020

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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“…It is now widely accepted that adequate vitamin D levels should be maintained in all life stages, from fetal development to old age. Low vitamin D status has been associated with an increased risk of rickets, osteoporosis, diabetes mellitus, cardiovascular disease, depression, autoimmunity and even pregnancy complications 5–12. Low prenatal and early life vitamin D levels may also increase susceptibility to schizophrenia and multiple sclerosis (MS) in later life 13–15.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status in an Australian patient population: a large retrospective case series focusing on factors associated with variations in serum 25(OH)D

et al. 2020

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ObjectivesTo investigate whether sex, age, medical specialty and seasonal variations in serum concentration of 25-hydroxy vitamin D (25(OH)D) are evident among an Australian patient population.DesignRetrospective study analysing the results of serum 25(OH)D lab tests and vitamin D supplementation from Royal Melbourne Hospital (RMH) between 2014 and 2017.SettingTertiary healthcare centre in Victoria, Australia.Participants30 023 patients (inpatient and outpatient) who had their serum 25(OH)D levels measured at RMH between 2014 and 2017.Main outcome measuresSerum 25(OH)D levels stratified according to patients’ sex, age and medical specialty admitted to, as well as the season and year (2014 to 2017) 25(OH)D level was measured.ResultsMean serum 25(OH)D level of study population was 69.9 nmol/L (95% CI 69.5 to 70.2). Only 40.2% patients in this cohort were sufficient in vitamin D (>75 nmol/L). On average, 25(OH)D levels in male patients were 6.1 units (95% CI 5.4 to 6.9) lower than in females. Linear regression analysis found that 25(OH)D levels increased by 0.16 unit (95% CI 0.14 to 0.18) for every year increase in age. One-way analysis of variance showed patients from neurology had the highest average 25(OH)D level, 76.8 nmol/L (95% CI 74.2 to 79.3) compared with other medical specialties. Mean 25(OH)D level during winter, 64.9 nmol/L (95% CI 64.2 to 65.6) was significantly lower compared with other seasons despite supplementation. Average 25(OH)D level measured in 2014, 71.5 nmol/L (95 CI% 70.8 to 72.2) was significantly higher than levels measured in 2016–2017.ConclusionsThere is a sex, age, medical specialty, seasonal and yearly variation in vitamin D status in an Australian patient population. The association between low vitamin D status and winter despite supplementation suggests other interventions are required to boost serum 25(OH)D levels.

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Vitamin D deficiency and cardiovascular pathology

Cited by 20 publications

References 43 publications

Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D

Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D

Assessment of the risk of incident heart failure in osteoporosis patients: a systematic review and meta-analysis of eligible cohort studies

Vitamin D status in an Australian patient population: a large retrospective case series focusing on factors associated with variations in serum 25(OH)D

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