Vitamin D Deficiency and Infertility: Insights From in vitro Fertilization Cycles

Paffoni, Alessio; Ferrari, Stefania; Viganò, Paola; Pagliardini, Luca; Papaleo, Enrico; Candiani, Massimo; Tirelli, Amedea Silvia; Fedele, Luigi; Somigliana, Edgardo

doi:10.1210/jc.2014-1802

Cited by 126 publications

(92 citation statements)

References 19 publications

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“…Recent reports have suggested that 25 hydroxyvitamin D ([25(OH)D]) was positively correlated with IVF pregnancy rate (Garbedian et al 2013, Paffoni et al 2014, Rudick et al 2014, whereas others found no significant association (Fabris et al 2014, Franasiak et al 2015, Abadia et al 2016. However, these studies were relatively small with between 100 and 150 participants in each deficient/ sufficient arms, and they defined different cut-off values for VitD insufficiency (<75 or <50 nmol/L), thus making comparisons difficult.…”

Section: Introductionmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.Reproduction (2017) 153 R29-R42

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Section: Introductionmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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“…They found that the clinical pregnancy rates were 20% and 31%, respectively, with an adjusted odds ratio of 2.15 for clinical pregnancy in women with vitamin D >/-20 ng/ml. Furthermore, a subgroup analysis revealed that the group with the highest serum level of vitamin D (>30 ng/ml) resulted in the highest chances of pregnancy [85].…”

Section: Vitamin D and Reproductionmentioning

confidence: 98%

“…In vitro studies, it has been shown that vitamin D receptors are expressed in murine endometrium and ovary throughout the estrous cycle, whereas knockout experiments have shown that vitamin D receptor null mice experience uterine hypoplasia and impaired folliculogenesis [85].…”

Section: Vitamin D and Reproductionmentioning

confidence: 99%

“…In a second study, the same authors examined serum 25(OH) D concentration among recipients of oocyte donation, finding a positive association between vitamin D status and clinical pregnancy rate and suggesting the specific effect of 25(OH)D levels on ART outcomes to be mediated by endometrial receptivity rather than by ovarian stimulation or embryo parameters [85]. Interestingly, both cyclic and early pregnancy endometrium represent an extrarenal site of vitamin D synthesis; thus, the effect of vitamin D at the uterine level is thought to be exerted via the vitamin D receptor (VDR) through either the regulation of target genes or the hormonal effects on the local immune response [84].…”

Section: Vitamin D and Reproductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and Female Reproduction

Elhusseini¹,

Lizneva²,

Gavrilova-Jordan³

et al. 2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D deficiency has an impact on the reproduction of more than 40% of reproductive age women globally. Fibroids are more common among African-American females owing to their decreased milk consumption and reduced absorption of ultraviolet rays, supporting the relation between vitamin D deficiency and fibroid development. Vitamin D has an inhibitory effect on leiomyoma cells by suppression of proliferation cell nuclear antigen (PCNA), BCL-2, BCL-w, CDK1, and catechol-Omethyltransferase (COMT) protein levels. A growing evidence support the relationship between vitamin D deficiency and endometriosis through overexpression of vitamin D recseptor (VDR) and α-hydroxylase enzyme, however, it is still unclear if the endometriosis patients could benefit from vitamin D supplementation. Effect of vitamin D supplementation on the metabolic outcomes of polycystic ovary (PCO) has been studied and reveled that it is negatively correlated with fasting glucose, fasting insulin, triglycerides, C-reactive protein, free androgen index, and Dehydroepiandrosterone (DHEAS) and positively associated with quantitative insulin sensitivity check index (QUICKI), high density lipoprotein cholesterol (HDL-C), and sexual hormone binding globulin (SHBG), whereas its impact on the ovarian function is still unclear. Vitamin D deficiency may worse the obstetrical outcomes, including preeclampsia, gestational diabetes, low birth weight, increased cesarean section rate, neonatal asthma, seizures, and preterm labor. The relationship between serum levels of 25-hydroxy-vitamin D (25(OH) D) and pregnancy rates in ART is still debatable, with the need to conduct more clinical trials toward it. The in vitro antiproliferative and prodifferentiative effect of vitamin D might find a role in control of hyperplastic overactive bladder. Several studies support that vitamin D deficiency constitutes a risk factor for development of many types of cancer such as breast, ovarian, and colorectal.

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“…The researchers concluded that vitamin D is an emerging factor influencing female fertility and IVF outcome. 22 Women with sufficient levels of vitamin D are significantly more likely to achieve clinical pregnancy following IVF.…”

Section: Clinical Efficiency Of Vitamin D In Female Infertilitymentioning

confidence: 99%

Role of sunshine vitamin D sufficiency in male and female infertility

Kumari

Hadalagi

2015

Int J Reprod Contracept Obstet Gynecol

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Vitamin D Deficiency and Infertility: Insights From in vitro Fertilization Cycles

Abstract: Vitamin D is an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.

Cited by 126 publications

References 19 publications

Molecular actions of vitamin D in reproductive cell biology

Molecular actions of vitamin D in reproductive cell biology

Vitamin D and Female Reproduction

Role of sunshine vitamin D sufficiency in male and female infertility

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Vitamin D Deficiency and Infertility: Insights From in vitro Fertilization Cycles

Abstract: Vitamin D is an emerging factor influencing female fertility and IVF outcome. Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation.

Cited by 126 publications

References 19 publications

Molecular actions of vitamin D in reproductive cell biology

Molecular actions of vitamin D in reproductive cell biology

Vitamin D and Female Reproduction

Role of sunshine vitamin &#147;D&#148; sufficiency in male and female infertility

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Product

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Role of sunshine vitamin D sufficiency in male and female infertility