Vitamin D Deficiency and Toxicity

Büyüker, Sultan Mehtap

doi:10.14744/ejmo.2018.0049

Cited by 4 publications

(3 citation statements)

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“…Cholecalciferol undergoes hydroxylation in the liver and kidney to yield its active form calcitriol. 8 Vitamin D has been recently highlighted as a regulator of immunity and allergy through multiple mechanisms including suppression of interleukin and immunoglobulin production by T and B -cells respectively. [9][10][11] However, the clinical evidence on the role of vitamin D in allergic disorders is inconclusive and such data on allergic conjunctivitis are particularly elusive.…”

Section: Introductionmentioning

confidence: 99%

Serum Vitamin D and Immunoglobulin E Levels In Patients With Seasonal Allergic Conjunctivitis

Alswailmi

Shah

Al-Mazaideh

et al. 2021

imjm

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INTRODUCTION: Seasonal allergic conjunctivitis (SAC) is a mild but common immunoglobulin E (IgE) mediated ocular allergy. Low serum vitamin D levels have been related to some allergic disorders but such data in the clinical context of SAC are missing. Our study investigated serum IgE and vitamin D levels in SAC patients. MATERIALS AND METHODS: A cross-sectional case-controlled study was conducted at University of Hafr Al-Batin, Saudi Arabia involving patients with established diagnosis of SAC and age[1]matched healthy control subjects. Standard patient evaluation of eye dryness (SPEED) questionnaire was scored for the frequency and severity of symptoms. Blood samples were taken to quantify serum IgE and vitamin D levels. Mean +- SD were calculated and independent sample t-test was applied for comparison between groups. RESULT: A total of 52 subjects were recruited into the study in which 26 subjects were patients aged between 20-60 years with an established diagnosis of SAC and another 26 subjects were age-matched healthy controls without any allergy. Mean serum IgE, vitamin D level and SPEED scores were significantly higher in SAC patients than in healthy control (2181.09 IU/ml +- 1062.33 vs 54.83 IU/ml +- 26.67; 38.96 ng/ml +- 11.37 vs. 29.47 ng/ml+- 11.73; 19.42 +- 4.81 vs. 2.19 +- 1.49) with p-value 0.001, 0.005, and 0.001 respectively. Mean vitamin D levels in both groups were within normal range. CONCLUSION: Higher serum vitamin D levels may be linked with SAC, but further research is needed to eliminate irregularities in the existing evidence on the influence of vitamin D in SAC.

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Section: Introductionmentioning

confidence: 99%

Serum Vitamin D and Immunoglobulin E Levels In Patients With Seasonal Allergic Conjunctivitis

Alswailmi

Shah

Al-Mazaideh

et al. 2021

imjm

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“…Vitamin D is a fat-soluble steroid hormone, may found in two forms: (1) Ergocalciferol (vitamin D 2 ) produced by plants and fungi. (2) Cholecalciferol (vitamin D 3 : 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) produced by the animal tissue and the cutaneous synthesis under the action of ultraviolet light at 7-dehydrocholesterol present in the skin (Zhang et al, 2015;Buyuker, 2019;de la Puente Yagüe et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Failure to determine appropriate doses in long-term treatments, age-inappropriate doses, and variable response to contraindication may result in toxicity (Buyuker, 2019). Therefore, in humans, vitamin D hypervitaminosis leads to increased calcium concentration in the blood leading to the calci ication of soft tissues and organs, such as the liver, kidney, heart and over calci ication of bones.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Al-Hayali

2020

ijrps

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The research was undertaken to evaluate the effects of vitamin D3 on the liver and kidney functions through some haematological and biochemical parameters. The results illustrate that high doses (30000 and 50000 IU) of vitamin D3 significantly reduce the rats' body weights in about 46% additionally much of symptoms like weakness, the rigidity of limbs, neurological irritation, difficulty in movement, respiration and deaths occurrence. The results also showed that the high doses vitamin D3 has a significant decreased in Red Blood Corpuscles (RBCs), Hemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), White Blood Corpuscles (WBCs), Lymphocytes (Lymph), Monocytes (Mono), Granulocytes (GRA) and Platelets (PLT) compared with the control group. In contrast, the Mean Corpuscular Hemoglobin Concentration (MCHC) and Platelet Distribution Width (PDW) significantly increased after 20-30 days of treatment . Besides, the results demonstrated a significant decrease in Alanine aminotransferase (ALT), Total Protein (TP), Creatinine (Cr) and increase in aspartate aminotransferase (AST), Blood Urea Nitrogen (BUN), Urea. While albumin did not give any significant differences. As well the study proved significantly increase in serum vitamin D3 concentration compared with the control group after 20-30 days of treatment. Since vitamin D3 can be beneficial for the organisms, but the overdoses of the vitamin can alter some parameters in the body.

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Effectiveness of an e-Book on Bone Health as Educational Material for Adolescents: Single-Group Experimental Study

Jamil,

Dhanaseelan,

Buhari

2024

JMIR Pediatr Parent

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Background Improved bone health during adolescence can have lifelong implications, reducing the risk of bone fragility. Objective This study aims to evaluate the effectiveness of an e-book in increasing knowledge about and promoting healthy practices related to bone health among Malay adolescents in Kuala Lumpur, Malaysia. Methods A total of 72 adolescents (female: n=51, 71%; age: mean 15, SD 0.74 y) were recruited from selected secondary schools. The participants answered a pretest web-based questionnaire on sociodemographic data, knowledge about osteoporosis, and physical activity. A video call was conducted to assess dietary calcium intake. Participants were provided with a link to an e-book on bone health and instructed to read it within 2 weeks. Postintervention assessments included those for knowledge, physical activity, dietary calcium intake, and acceptance of the e-book. Results There was a significant increase in the median knowledge score, which was 40.6% (IQR 31.3%-46.9%) during the pretest and 71.9% (IQR 53.9%-81.3%) during the posttest (P<.001). However, no changes were observed in dietary calcium intake or physical activity levels. Most participants did not meet the recommended calcium requirements (61/62, 98%) and exhibited sedentary behavior (pretest: 51/62, 82%; posttest: 48/62, 77%). The e-book, however, was well accepted, with the majority reporting that they understood the contents (70/72, 97%), liked the graphics (71/72, 99%), and approved of the layout (60/72, 83%) and font size (66/72, 92%) used. Conclusions The developed e-book effectively increases knowledge levels related to bone health and is well accepted among participants. However, this educational material did not improve bone health practices. Additional strategies are necessary to bridge the gap between knowledge and behavior change.

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Vitamin D Deficiency and Toxicity

Cited by 4 publications

References 0 publications

Serum Vitamin D and Immunoglobulin E Levels In Patients With Seasonal Allergic Conjunctivitis

Serum Vitamin D and Immunoglobulin E Levels In Patients With Seasonal Allergic Conjunctivitis

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Effectiveness of an e-Book on Bone Health as Educational Material for Adolescents: Single-Group Experimental Study

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