Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin d supplementation

Fernández, Nereida Fernández; Torres, Pedro L. Ballesteros; Matías, Diana Joao; Plaza, Francisco Jorquera; Goñi, José Luis Olcoz

doi:10.1016/j.gastre.2016.04.007

Cited by 10 publications

(5 citation statements)

References 31 publications

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“…Adaptive versus innate immunity. The role of VD in calcium regulation and bone homeostasis is well established (Holick et al, 2011;Lucey et al, 2013); however, VD has also been recognized as possessing immunomodulatory, anti-inflammatory, and antifibrotic properties (Arteh, Narra, & Nair, 2010;Fernandez-Fernandez et al, 2015;Kitson & Roberts, 2012). Additionally, VD has a key function in the management of cell proliferation and differentiation, both being extra-skeletal effects that are important in the pathogenesis and treatment of various etiologies of liver disease (Kitson & Roberts, 2012).…”

Section: Vd and The Immune Systemmentioning

confidence: 99%

“…Vitamin D (VD) has a number of pleiotropic effects including anti-inflammatory properties; antiapoptosis; antifibrosis; regulation of function in the kidney, heart, and immune system; and it maintains homeostasis by regulation of hormone secretion, cell proliferation, and differentiation (Lai & Fang, 2013). Research outlines the merits of VD supplementation (VDS) in patients with chronic liver disease (CLD) of various etiologies (Anty et al, 2014;DiCarlo et al, 2015;Eliades & Spyrou, 2015;Fernandez-Fernandez, Linares-Torres, Matias, Jorquera-Plaza, & Olcoz-Goni, 2015). Cited benefits can be stratified into areas such as the immune system (innate and adaptive), bone health, and all-cause mortality (Iruzubieta, Teran, Crespo, & Fabrega, 2014;Stokes, Volmer, Grunhage, & Lammert, 2013;Villar, Del Campo, Ranchal, Lampe, & Romero-Gomez, 2013).…”

Section: Introductionmentioning

confidence: 99%

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A vitamin D protocol post‐liver transplantation

Grant

2017

Journal of the American Association of Nurse Practitioners

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Background and purpose Adults with compromised liver function are inherently deficient and especially vulnerable to the consequences of vitamin D deficiency. Consequences of vitamin D deficiency include liver disease progression, infection, and graft failure. A vitamin D supplementation protocol is proposed to systematically optimize serum vitamin D levels according to guidelines in both pre‐ and post‐liver transplanted patients. Methods This quasiexperimental study included a sample of N = 45 post‐liver transplanted patients taking daily cholecalciferol (vitamin D3) 2500 units for 12 weeks, with a pre‐ and post‐lab measure of serum 25‐hydroxyvitamin D levels at a large academic facility. Conclusions Seventy‐eight percent of patients reached minimum guideline levels using the protocol with an average increase of serum vitamin D of 13.8 ng/mL. Long‐term outcomes of clinical significance may include decreased incidence of acute T‐cell‐mediated graft rejection and infections in the immunocompromised patient. Implications for practice Optimizing vitamin D in vulnerable patient populations such as chronic liver disease and the immunosuppressed posttransplanted patient has the potential to curtail complications of vitamin D deficiency. As a result, nurse practitioners employing a vitamin D protocol can create a favorable impact on patient quality of life, safety, and healthcare spending.

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Section: Vd and The Immune Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A vitamin D protocol post‐liver transplantation

Grant

2017

Journal of the American Association of Nurse Practitioners

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“…[12,39] Studies have demonstrated that vitamin D supplementation can improve liver function tests, reduce hepatic in ammation and brosis, decrease the risk of hepatocellular carcinoma, and improve functional status assessed by the Child-Pugh scale in patients with chronic liver disease. [40,41] However, further research is required to explore the clinical implications of vitamin D supplementation in liver cirrhosis, evaluate the e cacy and safety as an adjunctive therapy and delineate the details of its use including threshold for initiating therapy, dosage, optimal duration, delivery routes and therapeutic monitoring. These are necessary considerations when tailoring its use to various populations.…”

Section: Discussionmentioning

confidence: 99%

Association between serum vitamin D status and severity of liver cirrhosis: Implications for therapeutic targeting in Nigerian patients

Adiri,

Basil,

Onyia

et al. 2024

Preprint

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Background Liver cirrhosis is a chronic and progressive liver disease with significant global health implications. Recent evidence suggests an association between serum vitamin D levels and the severity of liver cirrhosis, potentially serving as a therapeutic target. This study aimed at investigating the relationship between serum vitamin D status and the severity of liver cirrhosis in a population of Nigerian patients. Methods This analytical, cross-sectional study involved 201 participants, including 103 with liver cirrhosis and 98 age- and sex-matched controls. Serum vitamin D was measured using ELISA, with deficiency defined as < 20 ng/ml. Cirrhosis severity was assessed using Child-Pugh and MELD scores. Spearman's correlation was used to assess the relationship between vitamin D and severity of liver cirrhosis while ordinal regression analysis assessed its performance as an indicator of the disease severity. Result Among cirrhotic patients, 36.9% were deficient, 31.1% insufficient, and 32.0% had sufficient vitamin D levels. Serum vitamin D showed strong negative correlations with Child-Pugh and MELD scores (r = -0.696, p < 0.001; r = -0.734, p < 0.001, respectively). Ordinal regression showed that higher vitamin D levels were associated with lower severity scores (Child-Pugh: OR = 0.856, 95% CI: 0.815–0.900, p < 0.001; MELD: OR = 0.875, 95% CI: 0.837–0.915, p < 0.001). Conclusion Lower serum vitamin D levels correlated with increased liver cirrhosis severity, suggesting its potential as both a prognostic marker and therapeutic target. Further studies should investigate the efficacy of vitamin D supplementation in improving cirrhosis outcomes.

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“…In a large cohort of patients with CLD ( n = 118), Lee et al observed that cirrhosis, African American race and female gender were independent risk determinants for severe VDD (25OHD < 17.5 nmol/L or 7 ng/mL) [ 49 ]. Decreased 25-hydroxylase activity, the malabsorption of fat-soluble vitamins, relatively insufficient vitamin D supplementation, malnutrition, low albumin and DBP, and poor sunlight exposure are some of the factors contributing to VDD in long-standing liver disease [ 50 , 51 , 52 , 53 ].…”

Section: Vitamin D and Chronic Liver Diseasementioning

confidence: 99%

Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention

Joshi¹,

Uday

2023

Nutrients

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Vitamin D plays a vital role in regulating calcium and phosphate metabolism and maintaining bone health. A state of prolonged or profound vitamin D deficiency (VDD) can result in rickets in children and osteomalacia in children and adults. Recent studies have demonstrated the pleiotropic action of vitamin D and identified its effects on multiple biological processes in addition to bone health. VDD is more prevalent in chronic childhood conditions such as long-standing systemic illnesses affecting the renal, liver, gastrointestinal, skin, neurologic and musculoskeletal systems. VDD superimposed on the underlying disease process and treatments that can adversely affect bone turnover can all add to the disease burden in these groups of children. The current review outlines the causes and mechanisms underlying poor bone health in certain groups of children and young people with chronic diseases with an emphasis on the proactive screening and treatment of VDD.

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Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin d supplementation

Cited by 10 publications

References 31 publications

A vitamin D protocol post‐liver transplantation

A vitamin D protocol post‐liver transplantation

Association between serum vitamin D status and severity of liver cirrhosis: Implications for therapeutic targeting in Nigerian patients

Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention

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