Vitamin D Deficiency in Postmenopausal Breast Cancer Survivors

Friedman, Claire F.; DeMichele, Angela; Su, Hua; Feng, Rui; Kapoor, Shiv; Desai, Krupali; Mao, Jun J.

doi:10.1089/jwh.2011.3009

Cited by 23 publications

(25 citation statements)

References 38 publications

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“…In our study of breast cancer patients, the first among Chinese women, we found that higher BMI was associated with vitamin D deficiency, as has been found in other studies of breast cancer patients [8], [14], [16]. These findings confirm the well-known associations of lower vitamin D levels with higher BMI observed in healthy adult populations [26]–[28].…”

Section: Discussionsupporting

confidence: 91%

Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients

et al. 2014

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BackgroundFew studies have investigated vitamin D status in association with modifiable lifestyle factors and clinical characteristics among breast cancer patients, with no studies among Chinese women, who may be at higher risk of vitamin D deficiency. We aimed to evaluate circulating 25-hydroxyvitamin D (25(OH)D) levels in association with clinical and lifestyle factors among 1,940 Chinese breast cancer patients.MethodsParticipants included breast cancer cases aged 22–77 from a population-based case-control study conducted in Shanghai, China during 1996–1998 (n = 1,044) and 2002–2005 (n = 896). Circulating 25(OH)D levels were measured in plasma samples (95% collected ≤6 months post-diagnosis). Prevalence ORs and 95% CIs were derived from multinomial logistic regression models, adjusting for age, season, and other factors.ResultsAbout 23% and 48% of women were vitamin D deficient (<30 nmol/L) or insufficient (30–50 nmol/L), respectively. Tumor characteristics were not associated with vitamin D status. Higher BMI was associated with increased odds of vitamin D deficiency (ORs (95% CIs): 1 (reference), 1.12 (0.85,1.47), and 1.57 (1.02,2.42), for <23, 23–<27.5, and ≥27.5 kg/m2, respectively, Ptrend <0.06). Total physical activity was associated with reduced odds of vitamin D deficiency (ORs (95% CIs):1 (reference), 0.84 (0.59,1.20), 0.65 (0.45,0.93), and 0.69 (0.48,1.00), for <7.65, 7.65–<10.6, 10.6–<13.5, ≥13.5 MET-hours/day, respectively, Ptrend <0.02). Smoking was associated with vitamin D insufficiency and deficiency (ORs (95% CIs): 2.50 (1.07,5.84) and 2.78 (1.11,6.95), respectively).ConclusionsIn the largest study to date, the prevalence of low vitamin D status was high among Chinese breast cancer patients and associated with higher BMI, smoking, and lower physical activity. Our findings support careful monitoring of vitamin D status and recommendations for supplementation and other lifestyle modifications that may improve vitamin D status in breast cancer patients.

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Section: Discussionsupporting

confidence: 91%

Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients

et al. 2014

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“…As in line with Vrieling et al's study (2011), we did not find clear differences in RT or HT use versus low levels of 25-OHD. Various studies have also shown that obesity and lower physical activity are associated with low serum levels of vitamin D in patients with BC (Lagunova et al, 2010;Vrieling et al, 2011;Friedman et al, 2012). In our study, according to the univariate analysis BMI>25 was found significantly associated with low levels of vitamin D levels, however correlation was not significant in multivariate analysis.…”

Section: Discussioncontrasting

confidence: 51%

Vitamin D Levels in Patients with Breast Cancer: Importance of Dressing Style

Alço¹,

Igdem²,

Dincer³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Risk factors for vitamin D deficiency include nonCaucasian race [5,6], living in northern latitudes, winter season [7], high BMI [8][9][10][11], diabetes mellitus Type 2 [11,12] and increasing age [13], among others. Non-Caucasian race and obesity have been confirmed by our group to be risk factors in postmenopausal breast cancer survivors [14].…”

Section: Vitamin D and Breast Cancer Vitamin D Levels And Clinical Deficisupporting

confidence: 53%

Vitamin D and breast cancer: evidence for biological and clinical significance

Clark

DeMichele

2012

Breast Cancer Manage.

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Both vitamin D deficiency and breast cancer are common. Laboratory evidence strongly suggests a biological role for vitamin D in normal breast cellular maintenance. Clinically, however, definitive associations between vitamin D and breast cancer risk and outcome have been challenging to decipher. A myriad of epidemiological studies have attempted to connect vitamin D with breast cancer risk, stage at diagnosis and outcome, but results vary. Here, we will closely examine the biologic evidence that supports an association between vitamin D and breast cancer and summarize the epidemiologic and clinical studies in this area. We will discuss ongoing trials and additional research questions that should be addressed in future studies.Vitamin D deficiency is common in general and breast cancer populations and is defined by the Institute of Medicine as a serum 25(OH)D level <20 ng/ml.The Institute of Medicine cut offs defining vitamin D deficiency and insufficiency, based on studies of bone fractures, may not be relevant for breast cancer outcomes. The optimal serum vitamin D level for breast cancer patients is unknown.Low serum level of vitamin D is associated with an increased risk of breast cancer in a recent meta-analysis.Calcitriol, the activated form of vitamin D, can be synthesized within breast cells.Calcitriol binds to intracellular vitamin D receptors and appears to repress proliferation and angiogenesis while inducing differentiation and apoptosis in normal breast cells.Calcitriol or its analogs have been safely combined with various chemotherapy drugs in Phase I and II studies.Combining vitamin D with cytotoxic chemotherapy agents in vitro and in vivo has been shown to increase the activity of some agents used for breast cancer.Vitamin D as a targeted therapy does not appear to be efficacious as a single agent in clinical trials to date.

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Vitamin D Deficiency in Postmenopausal Breast Cancer Survivors

Cited by 23 publications

References 38 publications

Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients

Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients

Vitamin D Levels in Patients with Breast Cancer: Importance of Dressing Style

Vitamin D and breast cancer: evidence for biological and clinical significance

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