Vitamin D deficiency in pregnant women from a non‐European ethnic minority population—an interventional study

Abstract

In view of the high incidence of subnormal vitamin D levels in women from ethnic minorities, we recommend biochemical screening of these women in early pregnancy, with subsequent supplementation where indicated.

Evaluation of Vitamin D Supplementation Doses during Pregnancy in a Population at High Risk for Deficiency

“…Previous studies of our group have revealed a rare secondary hyperparathyroidism frequency despite the high incidence of vitamin D deficiency among adolescents in our study population [28,29]. Similarly, Datta et al [21] reported normal PTH levels in 80% of vitamin D-deficient pregnant women. This data affirms that a 25OHD level of 20 ng/ml can be accepted for sufficiency in pregnancy, too.…”

“…However, previous studies have shown that daily supplementation with 200-600 IU vitamin D is inadequate to obtain sufficient vitamin D status, particularly in high-risk populations. Risk factors for hypovitaminosis D include a high latitude, excessive skin coverage by clothing, low amounts of outdoor activity, and darker skin pigmentation [19,20,21]. Despite the large amount of sunshine in Turkey (Kocaeli, where we conducted this study, has a latitude of 29° N), vitamin D insufficiency/deficiency is very common in this country and region.…”

Vitamin D Deficiency in Pregnancy and Lactation and Health Consequences

“…A representation of measured prevalence around the world is 8% in Western women in the Netherlands [36], 18% in the United Kingdom [37], 25% in the United Arab Emirates [38], 42% in Northern India [39], 46% in Canada [40], 50% in non-European ethnic minority women in South Wales [41], 59-84% in women with darker pigmentation in the Netherlands [36], 61% in New Zealand [42], 71% in Pakistani women in Norway [43], and 80% in Iran [44]. These studies and others show that high latitude, winter season, dark pigmentation, and full-body skin covering all increase the risk of vitamin D deficiency [35,36,38,39,42,44].…”

La vitamine D, nouveau candidat physiopathologique de la prééclampsie

“…Des données similaires sont retrouvées chez les femmes enceintes. Des études récentes montrent que 18 % des femmes enceintes en Angleterre, 25 % aux Émirats arabes unis, 80 % en Iran, 42 % au Nord de l'Inde et 60-84 % des femmes non occidentales aux Pays-Bas ont des concentrations en 25OHD inférieures à 25 nmol/l [10][11][12][13][14][15].…”

“…Dans cette étude, 1 198 primipares ont été étudiées, 4,9 % ont développé une PE. Une concentration sérique en 25OHD inférieure à 37,5 nmol/l, avant 22 SA, était associée à un risque cinq fois plus élevé de développer une PE (OR : 5,0 ; IC 95 % : [1,[7][8][9][10][11][12][13][14]1]) par rapport à une concentration supérieure à 75 nmol/l (indépendamment de l'ethnie, de la saison, du BMI avant la grossesse et de l'âge gestationnel au moment du prélèvement). Depuis un an, trois études observationnelles sont venues renforcer cette hypothèse.…”