Vitamin D deficiency in the critically ill

Koekkoek, W.A.C.; Zanten, Arthur R. H. van

doi:10.3109/07853890.2016.1162910

Cited by 6 publications

(7 citation statements)

References 35 publications

(42 reference statements)

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“…Some studies suggested the association of hypovitaminosis D and ICU mortality in the critically ill, while some studies demonstrated contradicting results. The latter correlated with our findings [1,2,6,8,11,12,14,17]. These inconclusive findings may be a result of different types of studied populations.…”

Section: Discussionsupporting

confidence: 89%

“…Vitamin D is a fat-soluble vitamin which is normally synthesized in the human skin and is mediated mainly by ultraviolet-B (UV-B) radiation from sunlight. Vitamin D compounds are subsequently activated in the liver to 25-hydroxycholecalciferol (calcidiol) and eventually converted to 1,25-hydroxycholecalciferol (calcitriol) in target organs for active functions [1]. Although vitamin D can be obtained from food products, such as milk, butter, fish, and mushrooms, the main source of vitamin D essentially comes from skin synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of admission serum 25-hydroxyvitamin D levels and clinical outcomes in critically ill medical patients

Bhurayanontachai

Maipang

Leelawattana

2018

Clinical Nutrition Experimental

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The aim of this study was to determine the incidence of hypovitaminosis D and the correlation of admission serum 25hydroxyvitamin D (25-OHD) levels and clinical outcomes in critically ill medical patients. Methods: A prospective, observational study was conducted. All critically ill medical patients admitted to the medical ICU were recruited. Blood sampling for serum 25-OHD was taken within 24 h after ICU admission. The levels of 25-OHD were dichotomized into deficiency and sufficiency groups. A serum 25-OHD level <20 ng/dL was defined as a vitamin D deficiency. All demographic data as well as biochemical tests were recorded. The primary outcome was incidence of hypovitaminosis D and 28-day mortality. The secondary outcomes were ICU and hospital mortality, ICU and hospital length of stay, mechanical ventilator days, and ICUacquired infection. Results: From 116 cases, the incidence of hypovitaminosis D was 64.66%. The median serum 25-OHD was 15.1 (3.0, 67.2) ng/dL. There was no difference in 28-day mortality between the vitamin D statuses (20% vs. 17.1%, p ¼ 0.70). However, the ICUacquired infection tended to be higher in the vitamin D deficiency group but this was not statistically significant (25.3% vs. 19.5%, p ¼ 0.07). Other secondary outcomes were comparable

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Correlation of admission serum 25-hydroxyvitamin D levels and clinical outcomes in critically ill medical patients

Bhurayanontachai

Maipang

Leelawattana

2018

Clinical Nutrition Experimental

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“…El aumento de la prescripción en el mes de junio puede, por tanto, deberse a la prescripción de envases pequeños para recuperar el estado nutricional alterado, secundario al hipercatabólico de la enfermedad (23,25,26). El soporte nutricional con envase pequeño se ha destacado por ser seguro y se ha señalado su eficiencia para ayudar al sistema inmunológico humano a combatir la COVID-19 (26)(27)(28).…”

Section: Discussionunclassified

“…Por último, como se podría esperar, los hospitales con mayor volumen de pacientes y complejidad son los que tienen más gasto. Analizando todos los hospitales por grupos etarios, se ve que no existe diferencia entre ellos, poniéndose de manifiesto que la COVID-19 es multisistémica y con gran afectación nutricional y elevada morbimortalidad no solo en la fase crítica sino a largo plazo, independientemente del tipo de hospital (26)(27)(28)(29).…”

Section: Discussionunclassified

Effect of COVID-19 on dietotherapeutic prescription during the first half of 2020 in the Community of Madrid

Luque¹,

Mataix²,

Candela³

et al. 2021

Nutr Hosp

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Efecto de la COVID-19 en la prescripción dietoterapéutica durante el primer semestre de 2020 en la Comunidad de Madrid Effect of COVID-19 on dietotherapeutic prescription during the first half of 2020 in the Community of Madrid 10.20960/nh.03758 10/21/2021 OR 3758 Efecto de la COVID-19 en la prescripción dietoterapéutica durante el primer semestre de 2020 en la Comunidad de Madrid Effect of COVID-19 on dietotherapeutic prescription during the first half of 2020 in the Community of Madrid

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“…Vitamin D is a hormone playing its primary role in the bone homeostasis, but it is also involved in regulating immunity, both innate and adaptive [12]. The prevalence of vitamin D deficiency is particularly high among institutionalized subjects or those with other concomitant diseases [13]. As described in a previous study, the prevalence of vitamin D insufficiency was high in patients with bloodstream infection and sepsis admitted to Internal Medicine wards [4].…”

Section: Introductionmentioning

confidence: 99%

Delta-Procalcitonin and Vitamin D Can Predict Mortality of Internal Medicine Patients with Microbiological Identified Sepsis

et al. 2021

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Background: The management of septic patients hospitalized in Internal Medicine wards represents a challenge due to their complexity and heterogeneity, and a high mortality rate. Among the available prognostic tools, procalcitonin (PCT) is considered a marker of bacterial infection. Furthermore, an association between vitamin D deficiency and poor sepsis-related outcomes has been described. Objectives: To evaluate the prognostic accuracy of two consecutive PCT determinations (Delta-PCT) and of vitamin D levels in predicting mortality in a population of patients with microbiological identified sepsis admitted to Internal Medicine wards. Methods: This is a sub-analysis of a previous prospective study. A total of 80 patients had at least two available consecutive PCT determinations, while 63 had also vitamin D. Delta-PCT was defined as a reduction of PCT > 50% after 48 h, >75% after 72 h, and >85% after 96 h. Mortality rate at 28- and 90-days were considered as main outcome. Results: Mortality rate was 18.7% at 28-days and 30.0% at 90-days. Baseline PCT levels did not differ between survived and deceased patients (28-days: p = 0.525; 90-days: p = 0.088). A significantly higher proportion of survived patients showed Delta-PCT (28-days: p = 0.002; 90-days: p < 0.001). Delta-PCT was associated with a lower 28-days (p = 0.007; OR = 0.12, 95%CI 0.02–0.46) and 90-days mortality (p = 0.001; OR = 0.17, 95%CI 0.06–0.48). A significantly higher proportion of deceased patients showed severe vitamin D deficiency (28-days: p = 0.047; 90-days: p = 0.049). Severe vitamin D deficiency was associated with a higher 28-days (p = 0.058; OR = 3.95, 95%CI 1.04–19.43) and 90-days mortality (p = 0.054; OR = 2.94, 95%CI 1.00–9.23). Conclusions: Delta-PCT and vitamin D represent two useful tests for predicting prognosis of septic patients admitted to Internal Medicine wards.

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Vitamin D deficiency in the critically ill

Cited by 6 publications

References 35 publications

Correlation of admission serum 25-hydroxyvitamin D levels and clinical outcomes in critically ill medical patients

Correlation of admission serum 25-hydroxyvitamin D levels and clinical outcomes in critically ill medical patients

Effect of COVID-19 on dietotherapeutic prescription during the first half of 2020 in the Community of Madrid

Delta-Procalcitonin and Vitamin D Can Predict Mortality of Internal Medicine Patients with Microbiological Identified Sepsis

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