Vitamin D deficiency in the oncology setting

DeMille, Debra; Piscitelli, Michael; Ocker, Aaron; Vuong, Carrie L.; Hartner, Lee; Lynch, Mary Pat

doi:10.12788/jcso.0004

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…A positive association exists between serum 1,25-dihydroxycholecalciferol levels and bone mineral density [17]. A recent study of 177 patients with various oncologic diagnoses showed the prevalence of vitamin D deficiencies and suggested that patients who are at high risk for vitamin D deficiency or poor bone health to be regularly screened for various cancers [18]. The impact of vitamin D in breast cancer [19], rheumatoid arthritis [20], prostate hyperplasia [21], hypertension risk [22], mortality in stroke patients [23], postpartum depression [24], obesity [25] and insulin resistance [26] has been also suggested and discussed.…”

Section: Vitamin D Metabolism and Physiological Rolesmentioning

confidence: 99%

First 25-hydroxyvitamin D assay for general chemistry analyzers

Saida

Chen

Tran

et al. 2014

Expert Review of Molecular Diagnostics

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25-Hydroxyvitamin D [25(OH)D], the predominant circulating form of vitamin D, is an accurate indicator of the general vitamin D status of an individual. Because vitamin D deficiencies have been linked to several pathologies (including osteoporosis and rickets), accurate monitoring of 25(OH)D levels is becoming increasingly important in clinical settings. Current 25(OH)D assays are either chromatographic or immunoassay-based assays. These assays include HPLC, liquid chromatography-tandem mass spectrometry (LC-MS/MS), enzyme-immunosorbent, immunochemiluminescence, immunofluorescence and radioimmunoassay. All these assays use heterogeneous formats that require phase separation and special instrumentations. In this article, we present an overview of these assays and introduce the first homogeneous assay of 25(OH)D for use on general chemistry analyzers. A special emphasis is put on the unique challenges posed by the 25(OH)D analyte. These challenges include a low detection limit, the dissociation of the analyte from its serum transporter and the inactivation of various binding proteins without phase separation steps.

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Section: Vitamin D Metabolism and Physiological Rolesmentioning

confidence: 99%

First 25-hydroxyvitamin D assay for general chemistry analyzers

Saida

Chen

Tran

et al. 2014

Expert Review of Molecular Diagnostics

View full text Add to dashboard Cite

show abstract

“…Furthermore, it regulates the release of various types of the pro-inflammatory cytokines as IL-2, IL-4, IL-12. Nowadays, it is used in the treatment of psoriasis and controls the proliferation rate of cancer cells in leukemia, breast and colon cancer (3,12 . The active form (calcitriol) has shorter half life (4-6 h) than the inactive form (days to weeks).…”

Section: Introductionmentioning

confidence: 99%