Vitamin D deficiency in women with polycystic ovary syndrome

Abstract

ObjectiveTo investigate: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group.MethodsWe recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls.ResultsWomen with PCOS showed no differences in the level of 25-hydroxy vitamin D (19.6±6.6 ng/mL in patients vs. 20.1±7.4 ng/mL in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOS patients or controls.ConclusionOur study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

“…Other studies suggest that vitamin D stimulates the expression of insulin receptors, which in turn augments insulin responsiveness for glucose transport [43,44]. Another important consideration is that the vitamin D/VDR complex regulates over 300 genes, including genes involved in glucose metabolism [45].…”

Polycystic Ovarian Syndrome; Association of Body Mass Index With Vitamin D Levels in Women

“…Our study discovered that the BMI in women with 20 Comparable outcome was also acquired by in another study in which 38 Korean women (18-40 years) were recruited with PCOS and 109 age and BMI matched non PCOS women were included. 16 Another research work was conducted in Iran by Firouzabadi et al on 100 infertile PCOS women also observed no significant association between BMI and serum vitamin D level before and after the management with vitamin D and calcium supplements. 21 Numerous studies have exhibited an inverse relationship between vitamin D and BMI in women with PCOS in the reproductive age group.…”

Vitamin D deficiency in women with polycystic ovary syndrome

“…В исследованиях, предшествующих наcтоящему, средний уровень витамина D варьировал от 11 до 31 нг/мл, а в большинстве из них он не превышал 20 нг/мл [20]. В нашем исследовании он составил 21,5 нг/мл, в то время как концентрация данного ну-триента менее 30 нг/мл наблюдалась у 82,8% пациен-ток.…”

“…В нескольких исследованиях у па-циенток с СПКЯ наблюдалась связь статуса витами-на D и метаболических факторов риска, таких как ИР, дислипидемия, артериальная гипертензия, уро-вень С-реактивного белка [11,12,14]. Нами подоб-ной ассоциации выявлено не было, что согласуется с данными других исследователей [20].…”