Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes

Yiu, Yau Chuen; Chan, Yap‐Hang; Yiu, Kai‐Hang; Siu, Chung‐Wah; Li, Sheung-Wai; Wong, Lai-Yung; Lee, Stephen W.L.; Tam, Sidney; Wong, Eric W. K.; Cheung, Bernard M Y; Tse, Hung‐Fat

doi:10.1210/jc.2010-2212

Cited by 116 publications

(70 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many authors have suggested that a low serum level of vitamin D 3 plays a role in the insulin resistance observed in PCOS, which may be corrected by vitamin D 3 replacement (39). In type 2 diabetes, vitamin D 3 improved the flow-mediated vasodilation of the brachial artery (9). The latter study demonstrated the direct vascular effects of vitamin D 3 treatment: the flow-mediated dilation of the brachial artery was significantly diminished in patients with low serum levels of vitamin D 3 .…”

Section: Figurementioning

confidence: 69%

See 1 more Smart Citation

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Sára

Péter

Masszi

et al. 2012

Fertility and Sterility

View full text Add to dashboard Cite

Objective: To investigate the vascular dysfunction caused by insulin resistance in polycystic ovary syndrome (PCOS) and the effectiveness of vitamin D in an animal model. Design: Controlled experimental animal study. Setting: Animal laboratory at a university research institute. Animal(s): Thirty female Wistar rats. Intervention(s): Rats were divided into groups at age 21-28 weeks. Twenty of them were subjected to dihydrotestosterone (DHT) treatment (83 mg/d); ten of them also received parallel vitamin D treatment (120 ng/100 g/wk). Oral glucose tolerance tests with insulin level measurements were performed. Gracilis arterioles were tested for their contractility as well as their nitric oxide (NO)-dependent and insulin-induced dilation using pressure arteriography. Main Outcome Measure(s): Several physiologic parameters, glucose metabolism, and pressure arteriography. Result(s): DHT treatment increased the passive diameter of resistance arterioles, lowered norepinephrine-induced contraction (30.1 AE 4.7% vs. 8.7 AE 3.6%) and reduced acetylcholine-induced (122.0 AE 2.9% vs. 48.0 AE 1.4%) and insulin-induced (at 30 mU/mL: 21.7 AE 5.3 vs. 9.8 AE 5.6%) dilation. Vitamin D treatment restored insulin relaxation and norepinephrine-induced contractility; in contrast, it failed to alter NO-dependent relaxation.

show abstract

Section: Figurementioning

confidence: 69%

“…Vitamin D may be also used as adjuvant therapy in women with PCOS (8). The positive effects of vitamin D administration on glucose metabolism (9,10) and the reduction of cardiovascular complications (11,12) are known, but vitamin D is not yet commonly used in PCOS therapy.…”

mentioning

confidence: 99%

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Sára

Péter

Masszi

et al. 2012

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…In the other hand, changes in level of vitamin D can influence endothelial function in pathological conditions as evident by Yiu & colleagues [33] who stated that deficiency of vitamin D was associated with endothelial dysfunction documented by FMD in 280 patients with T2DM. In addition, Sugden et al [37] reported that brachial artery FMD of T2DM patients significantly improved after single dose of vitamin D (100,000 IU) for 2 months.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Status of Vitamin D and Adhesive Molecules Biomarkers in Saudi Patients with Type 2 Diabetes Mellitus

Al-Sharif¹

2017

EMIJ

View full text Add to dashboard Cite

Background: Vitamin D (25-OHD) has an essential protective action on vascular endothelium and endothelial dysfunction is a risk valuable marker for risk of cardiovascular disorders, which are common among patients with Type 2 diabetes mellitus (T2DM).Objective: the aim of this study was to detect the link between level of vitamin D and adhesive molecules biomarkers in Saudi patients with type 2 diabetes mellitus. Material and Methods:Two hundred Saudi patients with T2DM of both sexes (132 females and 68 males), their age range was 48-59 years, the diabetes chronicity range was 9-11years and their body mass index (BMI) range was 31 to 37 Kg/m 2 . All participants received oral hypoglycemic agents e.g. metformin and/or pioglitazone and were selected from the Internal Medicine Out-patient Clinic, King Abdulaziz Teaching Hospital, Jeddah, Saudi Arabia. Participants with respiratory failure, hepatitis, renal failure, heart failure, pregnancy and smokers excluded from the study. According to vitamin D level, participants were assigned to one of three groups: vitamin D deficiency group (A): 25-OHD <20 ng/ml, vitamin D insufficiency group (B): 25-OHD =20-30 ng/ml and normal vitamin D group(C) 25-OHD >30 ng/ml. Results:The mean values of VCAM-1, ICAM-1 and E-selectin were significantly higher in vitamin D deficiency group (A) compared to vitamin D insufficiency group (B) and normal vitamin D group(C). Moreover, vitamin D showed a strong inverse relationship with VCAM-1, ICAM-1 and E-selectin in the three groups (P<0.05). Conclusion:There is an association between vitamin D deficiency and abnormal levels of adhesive molecules biomarkers in Saudi patients with type 2 diabetes mellitus.

show abstract

“…This process may be under the control of 25(OH)D3 (17). Recent studies have confirmed the relationship between 25(OH)D3 and depleted numbers of circulating endothelial progenitor cells in diabetes mellitus (18,19). However, the relationship between the number of circulating progenitor mononuclear cells in MetS patients and 25(OH)D3 levels is not yet fully clear.…”

Section: Introductionmentioning

confidence: 99%

Links between concentrations of serum 25-hydroxyvitamin D3 and the numbers of circulating progenitor mononuclear cells in patients with metabolic syndrome

et al. 2017

View full text Add to dashboard Cite

show abstract

Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes

Abstract: Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM.

Cited by 116 publications

References 20 publications

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Relationship between Status of Vitamin D and Adhesive Molecules Biomarkers in Saudi Patients with Type 2 Diabetes Mellitus

Links between concentrations of serum 25-hydroxyvitamin D3 and the numbers of circulating progenitor mononuclear cells in patients with metabolic syndrome

Contact Info

Product

Resources

About