Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

Abstract

Background: Vitamin D deficiency has been targeted as a cause of the increased incidence of allergic rhinitis. Many factors, including sun exposure, influence vitamin D levels. Indonesia is a country with abundant sunshine exposure throughout the year; therefore, Indonesian residents are not expected to have inadequate vitamin D levels. Objective: This study aimed to investigate whether vitamin D deficiency levels are correlated with disease spectrum among allergic rhinitis patients. Material and Method: A cross-sectional study was conducted in the Rhino-Allergy ORL-HNS Clinic at Dr. Hasan Sadikin General Hospital in Bandung, Indonesia, from March-June 2016. All subjects underwent skin prick tests and serum 25-hydroxy vitamin D levels examination. To measure the association between vitamin D deficiency level and severity of allergic rhinitis, a Rank-Spearman correlation test was used and significant level was determined when the p-value is <0.05. Results: A total of 46 allergic rhinitis patients (19 males, 27 females, aged 28.3 ± 6 years) were included in this study. 63% of allergic rhinitis patients had a severe vitamin D deficiency and 50% of them classified as having persistent moderate-severe based on ARIA-WHO classification. Vitamin D deficiency was found to be significantly correlated with severity of allergic rhinitis status (r s = −0.321; p = 0.005). Conclusion: We found vitamin D deficiency was correlated with allergic rhinitis classification and a significant proportion of allergic rhinitis patients showed a severe vitamin D deficiency.

Vitamin D and Diagnostic Colonoscopy for Colorectal Cancer in Indonesian Population: A Cross-sectional Study

“…One reason that may be related to data on low levels of Vitamin D in research subjects is the prevalence of Vitamin D deficiency which is indeed low in Asian or Indonesian populations in particular, as the study from Sari et al in 2017 showed Vitamin D levels of 292 women in North Sumatra, as many as 122 (41.7%) subjects showed a deficient level of Vitamin D, and 158 (54.1%) subjects showed an insufficient level of Vitamin D [22]. The study from Sudiro et al in 2017 showed that from 76 subjects, which consisted of 46 subjects with allergic rhinitis and 30 healthy subjects at the ear, nose and throat (ENT) Polyclinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, as many as 73 (96%) subjects showed a deficient level of Vitamin D. Two (2.6%) subjects showed an insufficient level of Vitamin D [23 ]. In the study from Judistiani et al in 2019, it was shown that of 203 pregnant women at the Gynecology Polyclinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, also suffered from deficient levels of vitamin D at a rate as high as 75% [24].…”

Validity and Reliability of The Indonesian Version of Patient Allergic Rhinitis Questionnaire and Allergic Rhinitis Prevalence in A Class Of 2018-2019 Medical Students of Universitas Padjadjaran, Indonesia

“…1 In a study conducted by Sudiro, dust mites were also the highest allergen. 15 The ARIA-WHO classification is the current classification of AR used. The classification was made by WHO because the conventional classification that divides AR based on the time of allergen exposure into chronic, seasonal, and occupational AR is not suitable for the patient's clinical symptom status.…”

“…The result of this study is similar to research conducted by Basyir and Sudiro at Dr. Hasan Sadikin General Hospital Bandung which stated that the most frequent classification was moderate-severe persistent. 15,16 Most of the patients who present to the physician have had moderatesevere AR disease for more than 4 days per week and more than 4 weeks. 17 The existence of geographical variations around the world can cause a difference in the distribution of aeroallergens, such as dust mites, in different regions.…”

“…Due to environmental factors such as temperature and humidity, dust mite allergen levels vary across regions. 15 The location of this study is Indonesia, which is an area with hot and humid temperatures. This can lead to dust mites as the highest cause of allergy in this study.…”

Role of Vitamin D in the Clinical Course of Nasal Polyposis

“…Particularly in allergic diseases, vitamin D acts on the human immune system through inhibitory functions on the growth cycle of human dendritic cells and the functions of T cells, stimulating the secretion of specific cytokines such as IL-10 [ 47 , 48 ]. It has been widely discussed how patients diagnosed with allergic disease are characterized by below normal levels of vitamin D and how this hormonal deficiency leads to a greater severity of symptoms [ 49 , 50 , 51 ]. In fact, the metabolite of vitamin D 1,25 (OH) 2VD3 can act by inhibiting T-helper 1 (TH1) and stimulating the responses of TH2 cells.…”