Vitamin D: Deficiency, Sufficiency and Toxicity

Alshahrani, Fahad; Aljohani, Naji

doi:10.3390/nu5093605

Cited by 249 publications

(201 citation statements)

References 50 publications

(51 reference statements)

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“…In the kidney, 25(OH)D is hydroxylated again into the metabolically active form, 1,25-dihydroxyvitamin D (1,25(OH) 2 D) [1,2]. In classifying individual vitamin D status, the cut-off values are based on 25(OH)D level in the blood [3]. The classical roles of vitamin D in maintaining bone health and regulating calcium metabolism are well established [4].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Chin¹,

Ima‐Nirwana²,

Ngah³

2015

The Aging Male

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Section: Introductionmentioning

confidence: 99%

Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Chin¹,

Ima‐Nirwana²,

Ngah³

2015

The Aging Male

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“…6 Chronic intake of 40-100 times (i.e., 40,000-1,00,000 IU/day) of normal physiologic requirements may result in vitamin D intoxication. 1,7 Our patient had serum vitamin D levels of 347ng/mL, which indicates a toxic level of vitamin D (i.e., >150 ng/mL). 7 She had taken Vitamin D in very high doses approximately 63000 IU/day for 2 months by means of injections and oral preparation.…”

Section: Discussionmentioning

confidence: 99%

“…1,7 Our patient had serum vitamin D levels of 347ng/mL, which indicates a toxic level of vitamin D (i.e., >150 ng/mL). 7 She had taken Vitamin D in very high doses approximately 63000 IU/day for 2 months by means of injections and oral preparation. These patients usually present with features of hypercalcaemia such as increased frequency of urination, increased thirst, abdominal pain, nausea, vomiting, constipation, headache, fatigue, altered sensorium and coma (in severe cases).…”

Section: Discussionmentioning

confidence: 99%

Iatrogenic hypercalcaemia in an elderly lady

Ashok

Suresh

Sachan

et al. 2017

jcsr

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An 83-year-old lady known to have type 2 diabetes mellitus, hypertension and primary hypothyroidism presented with the complaints of increased thirst of one month duration, diffuse abdominal pain, constipation and mild nausea of one week duration. She was found to have hypercalcaemia. Review of her treatment records revealed that she had received a high dose of vitamin D (average dose of 63,000 IU/day) over two months. Serum vitamin D was 347 ng/mL. Patient was advised to withhold all calcium and vitamin D preparations and further managed with intravenous 0.9% saline, diuretics and zoledronic acid. She improved clinically; her serum calcium levels became normal and she was subsequently discharged in stable condition. This case illustrates that inappropriate therapy with grossly excessive doses of vitamin D can result in intoxication leading on to hypercalcaemia.

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“…Toutefois, cette situation est très rare en dehors de pathologies caractérisées par une hypersensibilité à la vitamine D (comme les granulomatoses) ou les hypoparathyroïdies traitées par calcium et dérivés 1-hydroxylés de la vitamine D. Il est classiquement admis qu'une intoxication à la vitamine D n'apparaît jamais pour des concentrations de 25(OH)D 3 inférieures à 250 nmol/L (100 ng/ml), voire 325 nmol/L (150 ng/ml) (Alshahrani, et al, 2013) et que des doses de 10 000 UI/j sont sans danger majeur (Vieth, 1999).…”

Section: Dossierunclassified

Vitamine D : sources, métabolisme et mécanismes d’action

Landrier

2014

Cahiers de Nutrition et de Diététique

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Résumé -Longtemps cantonné à son rôle dans le métabolisme phosphocalcique, la vitamine D apparaît aujourd'hui comme une vitamine aux multiples potentialités, puisqu'étant impliquée dans de nombreux processus physiologiques. De part se double origine alimentaire et endogène, la vitamine D constitue une vitamine à part, dont les apports et les besoins restent délicats à définir et font actuellement débat. En revanche, le métabolisme de cette vitamine D est mieux connu. On sait de longue date que son métabolisme implique notamment une hydroxylation hépatique conduisant à la formation de la 25(OH)D ainsi qu'une hydroxylation rénale aboutissant à la formation du 1,25(OH) 2 D, le métabolite actif de la vitamine D. Ce métabolite est responsable des différents effets génomiques et non-génomiques de la vitamine D, dont les mécanismes d'action impliquent notamment un récepteur nucléaire spécifique, le Vitamin D Receptor (VDR) et diverses voies de signalisation contrôlées par un récepteur membranaire, la protein disulfide isomerase family A member 3 (Pdia3). Mots clés :Vitamine D / métabolisme / VDR / Pdia3 / nutrition Abstract -Vitamin D: sources, metabolism and mechanisms of action. Confined for a long time to its role in calcium and phosphate metabolism, vitamin D appears today as a vitamin with a large potential, through its involved in many physiological processes. Due to its double origin (from food and endogenous synthesis), vitamin D is a vitamin apart, with sources and requirements difficult to define that are currently discussing. However, the metabolism of the vitamin D begins to be known more precisely. This metabolism involves a first hepatic hydroxylation leading to the formation of 25(OH)D and second hydroxylation in kidney resulting in the formation of 1,25(OH) 2 D, the active metabolite of vitamin D. This metabolite is responsible for the various genomic and non-genomic effects of vitamin D, whose mechanism of action involves a specific nuclear receptor, the Vitamin D Receptor (VDR), and various signaling pathways controlled by a membrane receptor, the protein disulfide isomerase family A member 3 (Pdia3).Initialement identifiée pour son action antirachitique puis longuement cantonnée au métabolisme phosphocalcique, la vitamine D fait l'objet de toutes les attentions depuis quelques années, ce qui a permis des avancées majeures dans la connaissance de son métabolisme, de ses mécanismes d'action et par conséquent de ses nombreux effets métaboliques. Le niveau sanguin de 25-hydroxyvitamine D (25(OH)D) est le meilleur marqueur du statut en vitamine D. Lorsque le taux sérique de 25(OH)D est supérieur à 30 ng/ml (75 nmol/L), le statut vitaminique D peut être qualifié d'optimal. À l'inverse, le terme de statut vitaminique D suboptimal est souvent utilisé lorsqu'il est inférieur à 30 ng/ml. Cette valeur de 30 ng/ml est en effet considérée comme le seuil en deçà duquel apparaît une hyperparathyroïdie secondaire à l'hypovitaminose D,

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Vitamin D: Deficiency, Sufficiency and Toxicity

Cited by 249 publications

References 50 publications

Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men

Iatrogenic hypercalcaemia in an elderly lady

Vitamine D : sources, métabolisme et mécanismes d’action

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