Vitamin D deficiency, vitamin D receptor gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes

Vélayoudom-Céphise, Fritz-Line; Larifla, Laurent; Donnet, J.-P.; Maimaitiming, S.; Deloumeaux, Jacqueline; Blanchet, Alain; Massart, Catherine; Munoz-Bellili, N.; Merle, Sylvie; Chout, R.; Bonnet, Fabrice; Foucan, Lydia

doi:10.1016/j.diabet.2011.05.005

Cited by 45 publications

(32 citation statements)

References 31 publications

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“…The prevalence of obesity was high in our population, corroborating the already established link between excess weight and type 2 diabetes [1, 16]. Several studies in diabetic patients report an association between obesity and hypovitaminosis D [14, 17, 18]. Since vitamin D can be sequestered in body fat, obese patients tend to have lower serum levels.…”

Section: Discussionsupporting

confidence: 87%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

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ObjectivesDetermine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk.Research design and methodsWe conducted a cross-sectional study with consecutive patients treated at a University Hospital’s Endocrinology outpatient clinic located at 12°58′S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence).ResultsWe evaluated 108 patients with mean duration of T2DM of 14.34 ± 8.05 years and HbA1c of 9.2 ± 2.1%. Mean age was 58.29 ± 10.34 years. Most were women (72.2%), non-white (89.8%) and had hypertension (75.9%) and dyslipidemia (76.8%). Mean BMI was 28.01 ± 4.64 kg/m2; 75.9% were overweight. The prevalence of hypovitaminosis D was 62%. In multiple logistic regression, independent predictors of hypovitaminosis D were female gender (OR 3.10, p = 0.02), dyslipidemia (OR 6.50, p < 0.01) and obesity (OR 2.55, p = 0.07). In multiple linear regression, only total cholesterol (β = −0.36, p < 0.01) and BMI (β = −0.21, p = 0.04) remained associated with levels of 25-hydroxyvitamin D.ConclusionsUsing currently recommended cutoffs, the prevalence of hypovitaminosis D in Brazilians with T2DM was as high as that of non-tropical regions. Female gender, dyslipidemia and obesity were predictors of hypovitaminosis D. Low levels of 25-hydroxyvitamin D were correlated with high cholesterol and BMI values. Future studies are needed to evaluate whether vitamin D replacement would improve these parameters and reduce hard cardiovascular outcomes.

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Section: Discussionsupporting

confidence: 87%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

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“…Our observations were in support with the study conducted in Caribbean T2DM patients who had hypovitaminosis D and showed their association ApaI polymorphism [38]. Howard et al in 1995 also showed that ApaI may affect the circulatory Vitamin D levels [39].…”

Section: Discussionsupporting

confidence: 91%

Vitamin D Receptor Gene Polymorphisms and Haplotype Analysis in Type 2 Diabetes Mellitus Patients From North India

Taneja

Khadgawat

Mani

2017

Asian J Pharm Clin Res

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Objective: Vitamin D receptor (VDR) mediated Vitamin D signaling is important for expression of insulin gene and glucose transporters, which help in glucose uptake by cells. Current evidence suggests that four common polymorphisms (FokI, BsmI, ApaI, TaqI) of VDR gene are associated with Type 2 diabetes mellitus (T2DM) in different populations. However, there is a scarcity of data on VDR polymorphisms from Indian population.Methods: In the current study, total genomic DNA was isolated from 100 well-characterized T2DM patients and 100 healthy controls. We investigated the prevalence of FokI and ApaI polymorphisms in VDR gene of these patients by polymerase chain reaction-restriction fragment length polymorphismbased method. Taking help of our previous published data on TaqI and BsmI polymorphisms in same patients, the haplotype study was also conducted. Statistical analysis of data was performed using SPSS 21.0 software. Haplotype and linkage disequilibrium analysis was performed by Haploview software.Results: Both the wild (TT) and mutant (CC) genotype of FokI polymorphism showed a significant difference between patients and controls (p<0.001 and p<0.001, respectively). The frequency of mutant allele (C) was also significantly higher in T2DM patients than the controls (p<0.001). In case of ApaI, frequency of wild (GG) and mutant (CC) genotype was significantly different in patients and controls (p=0.017 and p=0.034). As per haplotype analysis, the CACT haplotype was predicted to be of significance in patients and consists of mutant alleles of three polymorphisms (FokI, BsmI, ApaI). Conclusion:Our study supports the association of FokI and ApaI polymorphism in T2DM. The haplotype analysis also indicates that the combinations of mutant allele of different VDR polymorphisms are probably responsible for increased susceptibility of these individuals toward T2DM.

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“…The genomic effects of 1,25-dihydroxyvitamin D in a wide variety of tissues are mediated by VDR [11]. The VDR gene is located on the long arm of chromosome 12 (12q12-14) and consists of at least 5 promoter regions, 8 protein-coding exons, and 6 untranslated exons, which are alternatively spliced [11,12,13]. More than 470 VDR single-nucleotide polymorphisms have been determined so far; among them, Fok I (rs2228570), Apa I (rs7975232), Bsm I (rs1544410), and Taq I (rs731236) have been thoroughly studied for their effects on various physiological and pathological phenotypes, such as cancer, diabetes, myocardial infarction, and CAD [13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh¹,

Djafarian²,

Alizadeh

et al. 2017

Lifestyle Genomics

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Background and Aims:ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. Methods: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk. Odds ratios with 95% confidence intervals were calculated to assess the strength of association in the dominant model, recessive model, allelic model, and genotypes contrast. Results: Nine studies involving a total of 5,259 cases and 1,981 controls were finally included in this meta-analysis. Overall, no significant associations were found between ApaI, FokI, TaqI, and BsmI polymorphisms and the risk of CAD in any of the genetic models (all p ˃ 0.05). Moreover, a subgroup analysis by ethnicity did not reveal a significant relationship between any of the examined polymorphisms and CAD risk in Caucasians and East-Asians for any model (all p ˃ 0.05). Conclusion: Current evidence suggests that the ApaI, FokI, TaqI, and BsmI polymorphisms of the VDR gene might not be associated with genetic susceptibility to CAD. Further well-designed studies with large sample sizes are needed to confirm our results.

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Vitamin D deficiency, vitamin D receptor gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes

Cited by 45 publications

References 31 publications

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Vitamin D Receptor Gene Polymorphisms and Haplotype Analysis in Type 2 Diabetes Mellitus Patients From North India

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

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