Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

Pott-Júnior, Henrique; Nascimento, Carla Manuela Crispim; Costa-Guarisco, Letícia Pimenta; Gomes, Grace Angélica de Oliveira; Gramani-Say, Karina; Orlandi, Fabiana de Souza; Gratão, Aline Cristina Martins; Santos-Orlandi, Ariene Angelini dos; Pavarini, Sofía Cristina Iost; Vasilceac, Fernando Augusto; Zazzetta, Marisa Silvana; Cominetti, Márcia Regina

doi:10.3390/nu12030748

Cited by 24 publications

(20 citation statements)

References 26 publications

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“…They calculated that each increase of 1 ng/mL 25(OH)D was associated with a significant reduction in total cholesterol and LDL and a 54% decrease in the risk of MetS. Subsequent studies also reinforce the possible association between vitamin D deficiency and MetS prevalence [ 35 , 36 , 37 ].…”

Section: Mets and Vitamin D Deficiencymentioning

confidence: 99%

Role of Vitamin D in the Metabolic Syndrome

et al. 2021

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The prevalence of hypovitaminosis D has risen in developed countries over the past few years in association with lifestyle changes and an increase in unhealthy habits. Vitamin D deficiency has been implicated in various diseases, including metabolic syndrome (MetS), which is clinically defined by a set of metabolic and vascular disorders. The objective of this study was to review scientific evidence on the relationship between MetS and vitamin D deficiency to support the development of prevention strategies and health education programs. An inverse relationship has been reported between plasma vitamin D concentrations and the features that define MetS, i.e., elevated serum concentrations of glucose, total cholesterol, low-density lipoproteins, triglycerides, glycosylated hemoglobin, and a high body mass index. Numerous studies have described the benefits of vitamin D supplementation to improve outcomes in individuals with MetS. Interventions to maintain optimal vitamin D concentrations are proposed as a preventive strategy against MetS.

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Section: Mets and Vitamin D Deficiencymentioning

confidence: 99%

Role of Vitamin D in the Metabolic Syndrome

et al. 2021

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“…Vitamin D (VD) is a fat-soluble hormone and is well known for functions in maintaining bone health and skin barrier. Its nutrigenomic and epigenetic functions have also been demonstrated through links between VD insufficiency or deficiency with various diseases, including tumorigenesis metastasis (Mahamat-Saleh et al 2020 ), autoimmune diseases (Sharief et al 2011 ; Ahmed Mohamed et al 2021 ), cardiometabolic disorders (Marquina et al 2019 ; Pott-Junior et al 2020 ), and even worse, coronavirus disease 2019 (COVID-19) risk and severity (Mitchell 2020 ; Pereira et al 2020 ). Potential evidence also indicates that VD intoxication induces calcium and phosphorus dysregulation, causing damage to tissues and organs (Razzaque 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The association between tobacco smoke exposure and vitamin D levels among US general population, 2001–2014: temporal variation and inequalities in population susceptibility

Yuan

2022

Environ Sci Pollut Res

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Tobacco smoking is endocrine-disrupting and may interfere with vitamin D endocrine systems (VDES), but supporting evidence is limited and inconsistent. Also, there is a lack of evidence on whether the association between tobacco smoke exposure and VD levels exhibit temporal variation. Data from the National Health and Nutrition Examination Survey was used to evaluate the association between tobacco smoke exposure and VD levels among US general participants from 2001 to 2014. We examined the linear association between serum cotinine and 25(OH)D concentrations, as well as relationship between tobacco smoke exposure categories (active, passive, non-smoking) with VD status (deficiency, inadequacy, sufficiency, intoxication), and assessed whether specific gender, age (3–11, 12–19, 20–59, ≥ 60 years), ethnicity/race, or body mass index (BMI) groups were disproportionately impacted. During 2001–2004, a decrease in both serum cotinine and passive smoking prevalence was observed, with a stabilized active smoking rate. The estimates for the association between tobacco smoke exposure and suboptimal VD levels increased over the study period. Overall results indicated that serum cotinine was negatively associated with 25(OH)D in all participants. Tobacco smoke exposure, including both active and passive smoking exposure, was associated with increased risk of VD deficiency. Moreover, active smoking was additionally related to enhanced risk of VD inadequacy. These associations showed some age and gender differences, with consistent and stronger associations observed in female adults. In contrast, effects of tobacco smoke exposure on VD levels were mostly negative or non-significant among children and adolescents aged 3–19 years. The percentage of US general population with active smoking exposure stabilized over the 14-year period and was still high. Tobacco smoke exposure may disrupt vitamin D levels with an increasing temporal trend in the risk. Our results also provided initial evidence of smoking exposure on VD intoxication, which needs to be further verified. Convincing studies have linked tobacco use exposure, to dysfunctional VDES accompanied with declined serum levels of VD metabolites. However, evidence on the association between tobacco smoke exposure and VD status was rather limited and inconsistent, and there were no researches to date that estimated the temporal variation of the association as well as the effects of smoke exposure on VD intoxication. This study analyzed national survey data, to evaluate the temporal trends in effects of tobacco smoke exposure on VD levels over a decade, and to comprehensively assess the impacts of tobacco smoke exposure on VD levels across specific subgroups. The evidence suggests that the prevalence of active smoking exposure stabilized over the 14-year period and was still high. Moreover, tobacco smoke exposure may disrupt vitamin D levels among general population, with an increasing temporal trend and age-, gender-differences in risk. Supplementary Information...

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“…Studies on the effects of vitamin D on insulin sensitivity have been inconsistent [ 34 , 35 ]. Although it has been proposed that vitamin D deficiency plays an important role in IR [ 36 ], many factors are involved, including age, obesity and the presence of prediabetes as well as other cardiovascular risk factors [ 37 ]. Inconsistent results between vitamin E and IR have also been reported [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy

et al. 2020

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Observational studies have investigated the potential modulatory effect of neuronal excitability by vitamins in epilepsy. We aimed to investigate whether the addition of multivitamin therapy (B6/B9, D, E and Q) to regular antiepileptic drug therapy could ameliorate seizures in patients with refractory focal epilepsy. We conducted a prospective cohort open study to investigate the effect and tolerability of add-on multivitamin therapy (daily dose: B6 100 mg, B9 5 mg, D 1000 IU, E 400 IU and coenzyme Q10 100 mg) in patients with intractable focal epilepsy. All patients had effect and safety assessments at baseline and after one, three and six months of the supplementation. Thirty patients (11 men and 19 women) with a mean age of 42.37 ± 9.40 years were recruited and four patients discontinued. The seizure frequency significantly decreased after the six-month supplementation (9.04 ± 18.16/month and 2.06 ± 3.89/month, p = 0.045). At the final visit, 62.5% of the patients showed a ≥50% reduction in seizure frequency, and 12.5% were seizure-free. As to safety and tolerability, most patients did not experience significant adverse events, although three patients reported seizure worsening. In conclusion, this pilot study demonstrated the therapeutic potential and essentially good tolerability of add-on multivitamin therapy in patients with refractory focal epilepsy.

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Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

Cited by 24 publications

References 26 publications

Role of Vitamin D in the Metabolic Syndrome

Role of Vitamin D in the Metabolic Syndrome

The association between tobacco smoke exposure and vitamin D levels among US general population, 2001–2014: temporal variation and inequalities in population susceptibility

An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy

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