Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice

Ali, Ammar; Shah, Shahid Ali; Zaman, Nasib; Uddin, Muhammad Nazir; Khan, Wajid; Ali, Abid; Riaz, Muhammad; Kamil, Atif

doi:10.1016/j.neuint.2020.104893

Cited by 72 publications

(37 citation statements)

References 40 publications

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“…Vitamin D deficiency has been linked to several neurological illnesses such as Parkinson's disease, schizophrenia, depression, and cognitive decline, suggesting that it plays a vital role in maintaining normal CNS function [93] , [94] , [95] . Another study in an animal model of oxidative stress and neurodegeneration reported that vitamin D plays an important role in memory and cognition, and that its deficiency could accelerate cognitive impairment [96] : both the immunomodulatory and antioxidant effects of vitamin D significantly reduced different pro-inflammatory interleukins and increased the synthesis of anti-inflammatory chemical mediators ( Fig. 2 ).…”

Section: Vitamin D Neuroinflammation and Neurodegenerationmentioning

confidence: 95%

“…2 ). These effects were accompanied by a decrease in amyloid β-protein formation and an increase in memory performance [96] . Taken together, these findings reinforce the hypothesis that vitamin D supplementation could be an effective option to avoid the development and progression of neurodegenerative pathologies such as Parkinson's and AD in post-COVID-19 patients [97] , [98] , [99] , [100] .…”

Section: Vitamin D Neuroinflammation and Neurodegenerationmentioning

confidence: 98%

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COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

et al. 2022

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Section: Vitamin D Neuroinflammation and Neurodegenerationmentioning

confidence: 95%

Section: Vitamin D Neuroinflammation and Neurodegenerationmentioning

confidence: 98%

COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

et al. 2022

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“…Active substances such as resveratrol, apple polyphenol extract [19], ginsenoside, astaxanthin [20], and vitamin D [21] can promote the expression of SIRT1 and activate AMPK [22], FoxO1 [23], PGC1-α [24], and Nrf2 downstream of SIRT1. These substances can also decrease the expression of SIRT1.…”

Section: The Role Of Sirt1/foxo1 Pathway Of Skeletal Muscle In Preven...mentioning

confidence: 99%

The regulatory role of the SIRT1/FoxO1 pathway in the prevention of insulin resistance in skeletal muscle by aerobic exercise in mice

Wang

Yang

et al. 2022

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Silent information regulator proteins (SIRT) play key roles in glucose and lipid metabolism and homeostasis. The SIRT1 inhibitor was used to investigate the mechanism of the SIRT1/FoxO1 (Forkhead box O1) pathway in mice and its function in the prevention of insulin resistance in skeletal muscle. Forty male mice were randomly divided into a control group and three experimental groups (NH: high-fat diet, HE: high-fat diet plus exercise, and HES: high-fat diet plus exercise and SIRT1 inhibitor). After 14 weeks, the fat weight, blood glucose level, and HOMA-IR score in HES were significantly increased compared to those in HE (P < 0.01). The same parameters were significantly decreased in HE compared to those in the NH group (P < 0.01). Mitochondrial 8-OHdG (8-hydroxy-2 deoxyguanosine) level of the HES group was significantly higher than that of the HE group (P < 0.01). Compared with NH, the 8-OHdG and 4-HNE (4-hydroxynonenal) level were significantly decreased in HE (P < 0.01). Histologic evaluation demonstrated mitochondrial vacuoles in HES, while a clean arrangement of mitochondrial cristae was observed in HE. FoxO1 acetylation was enhanced in HES compared to that in HE (P < 0.01). The insulin resistance was induced in mice after 14-week high-fat diet, while glucose metabolism was significantly improved by aerobic exercise. The physiologic adaptations induced by exercise were not observed in the presence of an SIRT1 inhibitor. Thus, the SIRT1/FoxO1 pathway effectively regulates glucose metabolism during aerobic exercise and also prevents fat-induced peroxidation injury in skeletal muscles.

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“…A reduced concentration of the active form of VitD might improve the AD and dementia risk in a significant way [213]. In the D-Galactose-induced memory impairment mice model, neuroprotective activity is shown by VitD via SIRT1/Nrf-2/NF-kB signaling pathways [214]. Therefore, the VitD level should be checked and managed by the patients during AD treatment [215].…”

Section: Vitamins Based Animal and Cellular Studies In Alzheimer's Diseasementioning

confidence: 99%

The Role of Vitamins in Neurodegenerative Disease: An Update

et al. 2021

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Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

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Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice

Cited by 72 publications

References 40 publications

COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

The regulatory role of the SIRT1/FoxO1 pathway in the prevention of insulin resistance in skeletal muscle by aerobic exercise in mice

The Role of Vitamins in Neurodegenerative Disease: An Update

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