Vitamin D, glucose, insulin, and insulin sensitivity

Tai, Kamilia; Need, A. G.; Horowitz, Michael; Chapman, Ian

doi:10.1016/j.nut.2007.11.006

Cited by 136 publications

(121 citation statements)

References 97 publications

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“…It has been proposed that vitamin D deficiency directly promotes IR. [16] The findings of our study support this theory. The data from various studies are discordant, while a study on 7904 individuals by Ford et al showed negative correlation of vitamin D levels with metabolic syndrome.…”

Section: Discussionsupporting

confidence: 84%

Study of vitamin D levels and its correlation with insulin resistance

Sahasrabuddh¹,

Pitale²,

Gupta³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Hypovitaminosis D has been reported as a risk factor for glucose intolerance. Although traditionally named as sunshine vitamin, in India, it is paradoxically deficient. Obesity is frequently associated with insulin resistance (IR) and prediabetes and other components of metabolic syndrome. Obesity is also commonly associated with hypovitaminosis D due to the capacity of adipose tissue to store 25-dihydroxy vitamin D making it biologically unavailable. Aims and Objectives: This study is designed to know the prevalence of hypovitaminosis D and study its relation with IR from Central India. Materials and Methods: A total of 594 patients were enrolled in the study. Of these, 560 met inclusion-exclusion criteria. Body mass index (BMI), Waist-hip ratio, and blood pressure were measured. Fasting sample was taken for the following investigations: Fasting blood sugar, fasting insulin, intact parathormone, lipid profile, and vitamin D were done. Homeostatic model assessment (HOMA-IR) was calculated. Based on BMI, they were divided into two groups: Cases (n = 168) with BMI >25 and controls (n = 392) BMI <25. Results: Overall vitamin D deficiency was seen in 413 (73.75%) with deficiency in cases 93.45% and 65.3% in control group. Severe vitamin D deficiency was seen in 14.88% cases and 11.99 controls. Mean serum vitamin D levels were 18.31 ± 11.53 in cases and 26.4 ± 12.28 0.002 (HS) in controls. Vitamin D sufficiency was seen in only 6.54% of cases and 34.69% of controls. Individuals with severe vitamin D deficiency have maximum IR. The parameters of IR were significantly seen to be associated with vitamin D levels. Conclusion: Vitamin D deficiency is rampant in Central India and shows strong independent association with IR.

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Section: Discussionsupporting

confidence: 84%

Study of vitamin D levels and its correlation with insulin resistance

Sahasrabuddh¹,

Pitale²,

Gupta³

et al. 2017

Natl J Physiol Pharm Pharmacol

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“…It is possible that an increase in the sample size might lead to significant correlations. Several observations have linked vitamin D deficiency to alterations in glucose metabolism (11,12). Cross-sectional studies have shown inverse correlations between 25(OH)D levels and both fasting serum glucose (12,24) and insulin resistance (13)(14)(15)24).…”

Section: Discussionmentioning

confidence: 99%

“…Among these effects, several studies in adults suggest a link between vitamin D and cardiovascular disease risk (2-4), diabetes or HbA1c levels (5,6), hypertension (7)(8)(9)(10), and dyslipidemia (4). Reduced circulating 25-hydroxyvitamin D (25(OH)D) concentrations were found to be associated with higher fasting serum glucose (11,12), reduced insulin sensitivity (13)(14)(15), increased risk of type 2 diabetes (5,16,17) and either increased risk (18,19) or no effect on the metabolic syndrome (MetS) (20,21). On the other hand, results from interventional studies are controversial, showing either no effect of vitamin D supplementation on the risk of developing diabetes (22) or an attenuation of the increase in glycemia and insulin resistance that occur over time (23).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

Gannagé‐Yared¹,

Chedid²,

Khalife³

et al. 2009

European Journal of Endocrinology

161

134

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Objectives: Several studies suggest a link between circulating 25-hydroxyvitamin D (25(OH)D) and metabolic risk factors. However, this relation has been mainly studied in elderly and/or obese subjects. In addition, the relation between 25(OH)D and adiponectin is unclear. The purpose of this study is to look at these relations in non-obese young individuals. Design: We investigated the relation between serum 25(OH)D and adiposity, blood pressure, glucose metabolism, lipid profile, and adiponectin in 381 randomly selected university students (201 males and 180 females, mean age 23.9G3.9). Results: In the overall population, 25(OH)D is significantly inversely correlated with body mass index (BMI), systolic blood pressure (SBP), waist circumference (WC), fasting plasma glucose (FPG), insulin levels, and homeostasis model assessment of insulin resistance (HOMA index) and positively correlated with adiponectin and high density lipoprotein-cholesterol (P!0.01 for all variables). In males, these correlations are still significant for BMI, SBP, WC, and adiponectin (PZ0.02, PZ0.01, PZ0.04 and PZ0.01 respectively); also, 25(OH)D is inversely correlated with low density lipoprotein (LDL)-cholesterol (PZ0.007). In females, 25(OH)D is only inversely correlated with FPG and HOMA index (P!0.001 and PZ0.03 respectively). In multivariate regression analysis models, after adjustment for sex and BMI, 25(OH)D is an independent predictor of FPG and SBP (PZ0.032 and PZ0.05 respectively) in the overall population, while in males 25(OH)D is a predictor of LDL-cholesterol and SBP independently of BMI (PZ0.007 and PZ0.035 respectively). Conclusion: In non-obese young subjects, we observe new relationships between 25(OH)D and several metabolic risk factors and adiponectin. Further research is needed to elucidate the gender differences and to look at the relation between 25(OH)D and adiponectin.European Journal of Endocrinology 160 965-971

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“…Interestingly, there is increasing evidence that vitamin D affects insulin and glucose metabolism [36][37][38][39], and although the exact pathophysiology remains somewhat elusive, several studies have examined this association. A number of studies have demonstrated an increase in serum parathyroid hormone (PTH) when vitamin D levels are low [40][41][42].…”

Section: Polycystic Ovarian Syndromementioning

confidence: 99%

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

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Vitamin D, glucose, insulin, and insulin sensitivity

Cited by 136 publications

References 97 publications

Study of vitamin D levels and its correlation with insulin resistance

Study of vitamin D levels and its correlation with insulin resistance

Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

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