Vitamin D in amyotrophic lateral sclerosis

Libonati, Laura; Onesti, Emanuela; Gori, María; Ceccanti, Marco; Cambieri, Chiara; Fabbri, Angelo; Frasca, Vittorio; Inghilleri, Maurizio

doi:10.11138/fneur/2017.32.1.035

Cited by 27 publications

(24 citation statements)

References 28 publications

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“…41 Another study on Vitamin D in amyotrophic lateral sclerosis represented that in chronic neurological diseases levels of vitamin D in blood appeared low but there was no signi cant differences found between the level of vitamin D and Amyotrophic lateral sclerosis patients (18.8±12.2) and the healthy subjects (20.7±10.1). 42 Similarly, Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia, the study didn't nd the association between baseline 25(OH)D levels and cerebral Aβ in any of the brain regions studied. 43 Vitamin D is not associated with incident dementia or cognitive impairment over an 18 years period of time another study presented as the result showed that the adjusted HR for the continuous GRS for all cause dementia was 1.04 (95% CI:0.91, 1.19).…”

Section: Discussionmentioning

confidence: 90%

Vitamin-D in Nepal: are we really vitamin-D deficient?

Chandra¹,

Pant²,

Rajbhandari³

et al. 2020

Preprint

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Background: Recently, there have been a surge in research worldwide regarding relation of vitamin D with several diseases. Many neurological diseases like multiple sclerosis, Alzheimer’s disease as well as other diseases like cardiovascular disease have shown positive correlation with vit. D deficiency measured according to the international level. Most of the research on possible role of vitamin D has been carried out in America and European nations, while there is paucity of research in low- and middle-income nations (LMICS) that are nearer to the equatorial area. In countries like Nepal, geographically they lie near to the equator and sunlight exposure is well enough and milk consumption is quite moderate. Thus, special consideration for vitamin D level in Asian population seems plausible. This will not only help us to cover the vitamin D deficient population but will help us to avoid excessive and unnecessary usage of it.Objectives: This study aims to detect the situation of vitamin D in Nepalese population and secondly to find out the suitable normalized reference range for serum vitamin D in multi-ethnic Nepalese population.Methodology: This was a hospital based prospective study. A prospective study was conducted using purposive sampling technique with in-vivo and in vitro bio-physiological method to collect serum vitamin D level. After rigorous inclusive and exclusive criteria, a total of 107 subjects were collected.Result: The present study showed that 32% of participants had deficit serum Vitamin-D level (<15 ng/mL), 48% of subjects had insufficient serum level of Vitamin-D (15-<30ng/mL) and 20% of participants had sufficient serum level of Vitamin-D (>30ng/mL). Study showed that there is lower degree of positive relationship of Body Mass Index (BMI) with Serum Vitamin-D level (r=0.162, p=0.094), History of chronic illness (χ2=0.10, p=0.03), timing of occurrence of stroke (χ2=11.41,p=0.017) and diagnosis (χ2=21.19, p=0.011) had significant association with Serum vitamin-D level at p<0.05.Conclusion: There is direct significant association of Serum Vitamin D with socio-demographic variables when international unit is considered. Neurological disorder showed positive association with serum vitamin D level.

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Section: Discussionmentioning

confidence: 90%

Vitamin-D in Nepal: are we really vitamin-D deficient?

Chandra¹,

Pant²,

Rajbhandari³

et al. 2020

Preprint

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“…A retrospective study including 57 ALS patients reported neither significant differences in 25(OH)D 3 /D 2 blood levels in comparison to 57 healthy individuals nor an improvement of the recorded clinical, ALS-related variables after oral supplementation of 100,000 IU of vitamin D 3 /week for 4 weeks and thereafter 25,000 IU every 15 days compared to untreated participants. But as discussed by the authors, potential limitations of this study are its retrospective character and the sample size [131]. Two earlier studies also described an absent relationship between serum 25(OH)D 3 levels and prognosis in ALS [132,133].…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 77%

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Lauer¹,

Janitschke²,

Hartmann³

et al. 2020

Vitamin D Deficiency

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Approximately 90% of the elderly population in the western countries has at least a mild to moderate vitamin D hypovitaminosis. Besides the well-known function of vitamin D in calcium homeostasis, it has been recently found that several enzymes and receptors involved in its homeostasis are expressed in the nervous system and brain suggesting also an important role in the brain homeostasis. Interestingly, epidemiological and clinical studies found reduced vitamin D level associated with an increased risk of several neurodegenerative disorders. In this chapter, we focus on a potential link between vitamin D and Alzheimer's disease, Parkinson's disease, multiple sclerosis, prion disease, and motor neuron disease. Epidemiological studies were summarized, an overview of the known potential underlying pathomolecular mechanisms are given, and results from clinical studies dealing with vitamin D supplementation were presented. As an outlook, recent literature suggesting an impact of vitamin D on autism spectrum disease, depression, and schizophrenia are briefly discussed. In conclusion, the identification of an abundant vitamin D metabolism in the brain and the tight link between the increasing number of several neurological and mental disorders emphasize the need of further research making a clear recommendation of the intake and supplementation of vitamin D in a growing elderly population.

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“…Included studies reported (a) the levels of vitamin D in ALS patients compared with those in control subjects (4 studies: 163 ALS and 276 control patients); (b) correlations of levels of vitamin D with clinical markers of prognosis (as ALSFRS-S or survival; 9 studies: 986 ALS patients); or c) effect of supplementation with vitamin D on clinical parameters of progression (3 studies: 77 vitamin D-treated ALS patients, 41 non-treated ALS patients). Of the retained studies, six were retrospective (13,16,(33)(34)(35)(36) and seven prospective (14,15,(37)(38)(39)(40)(41). Four studies were only available as abstracts (14,34,35,38).…”

Section: Summary Of Included Studiesmentioning

confidence: 99%

“…Four observational studies reported levels of vitamin D in ALS patients and in control subjects (healthy controls in three studies and other neurological conditions in the fourth) (36)(37)(38)(39). Overall, only Cortese et al (38) reported a significant difference in vitamin D levels between ALS patients and controls.…”

Section: Prevalence Of Vitamin D Deficiency In Amyotrophic Lateral Scmentioning

confidence: 99%

“…Heterogeneity could not be explained by any particular characteristic of the study of Cortese and co-workers-apart from its presentation as only an abstract. However, the analysis of bias from retrieved studies raised concerns, as two studies (36,38) displayed a moderate risk of bias, one study was rated with high risk of bias (39), and only one study (37) presented low risk of bias (Supplementary File 3).…”

Section: Prevalence Of Vitamin D Deficiency In Amyotrophic Lateral Scmentioning

confidence: 99%

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Is There a Role for Vitamin D in Amyotrophic Lateral Sclerosis? A Systematic Review and Meta-Analysis

et al. 2020

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Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition characterized by the progressive loss of motor neurons. Patients usually die 3-5 years after diagnosis from respiratory failure. Several studies investigated the role of vitamin D as a biomarker or a therapeutic option for ALS patients. To clarify the scientific evidence, we performed a systematic review and different meta-analyses regarding the potential role of vitamin D in ALS. Methods: We performed a systematic review of clinical trials, cohorts, and case-control studies retrieved from PubMed, EMBASE, and Cochrane databases reporting vitamin D levels as a putative biomarker for ALS diagnosis or prognosis or the effect of vitamin D supplementation in ALS patients. Whenever possible, data were pooled using a random-effects model, with an assessment of heterogeneity. Results: Out of 2,996 articles retrieved, we finally included 13 research articles, 12 observational studies (50% prospective), and 1 clinical trial. We found that ALS patients had slightly lower levels of vitamin D than controls (mean difference −6 ng/ml, 95% CI [−10.8; −1.3]), but important confounding factors were not considered in the studies analyzed. We found no relationship between vitamin D levels and ALS functional rate score-revised (ALSFRS-R), with highly heterogeneous results. Discordant results were reported in three studies regarding survival. Finally, five studies reported the effects of vitamin D supplementation with discordant results. Two of them showed a small improvement, whereas two others showed a deleterious effect on ALSFRS-R. One very small clinical trial with important methodological limitations showed some improvement in ALSFRS-R with high doses of vitamin D compared with normal doses. Conclusions: Our review did not find evidence to support the role of vitamin D on ALS diagnosis, prognosis, or treatment. Most studies had important limitations, mostly regarding the risk of bias for not considering confounding factors. Vitamin D supplementation should be offered to ALS patients to avoid other health issues related to vitamin D deficiency, but there is not enough evidence to support the use of vitamin D as a therapy for ALS.

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Vitamin D in amyotrophic lateral sclerosis

Cited by 27 publications

References 28 publications

Vitamin-D in Nepal: are we really vitamin-D deficient?

Vitamin-D in Nepal: are we really vitamin-D deficient?

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Is There a Role for Vitamin D in Amyotrophic Lateral Sclerosis? A Systematic Review and Meta-Analysis

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