Vitamin D in respiratory viral infections: a key immune modulator?

Vaghari‐Tabari, Mostafa; Mohammadzadeh, Iraj; Qujeq, Durdi; Majidinia, Maryam; Alemi, Forough; Younesi, Simin; Mahmoodpoor, Ata; Maleki, Masomeh; Yousefi, Bahman; Asemi, Zatollah

doi:10.1080/10408398.2021.1972407

Cited by 17 publications

(11 citation statements)

References 175 publications

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“…Vitamin D deficiency is widely prevalent worldwide. 24 Its association has been documented to either predispose or alter the course of several infective and autoimmune conditions such as respiratory and systemic infections, type 1 diabetes, systemic lupus erythematosus, systemic sclerosis, etc., probably due to the lack of immunomodulatory effects of vitamin D. [25][26][27][28][29] VDD also affects several outcome parameters in hospitalized patients. 29,30 Its role in the disease severity and progression and the possibility of amelioration were suggested during the initial phase of the Covid-19 epidemic.…”

Section: Discussionmentioning

confidence: 99%

Covid-19 and Vitamin D Deficiency: A Scientometric Assessment of Global Publications during 2020-21

Dayal¹,

Gupta²,

Surulinathi³

et al. 2021

JYP

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The world is currently witnessing an unprecedented crisis of the Covid-19 pandemic. The pandemic has caused severe devastation globally and the crumbling of health infrastructures in developing countries. 1,2 The Covid-19 is associated with significant morbidity and mortality due to its severe effects on the respiratory system and other organ systems, especially in those with comorbid conditions. 3,4 In addition to comorbidities, several other risk factors, such as female sex, lack of Covid-19 appropriate behavior, large households, BCG vaccination, etc., are presumed to play a role in the Covid-19-related morbidity and mortality. [5][6][7][8] One such risk factor which has been postulated to contribute to either acquisition or progression of Covid-19 is Vitamin D deficiency (VDD). 9Since the onset of the Covid-19 pandemic, the role of VDD has been a topic of intense research. 10 Several studies have reported low serum levels in patients with Covid-19, especially those with severe disease, and in those who died of Covid-19. 10 The recent meta-analysis also concluded that patients with VDD had an increased risk of developing the severe disease but not a fatal outcome. 10 The studies conducted on the association between VDD and Covid-19 show a large degree of heterogeneity due to the differences in enrolment criteria of patients (age, body mass index, ethnicity, comorbidities), the country of residence, and the criteria used to define the severity of Covid-19. 10 Another similar meta-analysis concluded that the evidence for VDD's association with ICU admission, inflammation, hospitalization, and pulmonary involvement in Covid-19, is still inconsistent and insufficient. 11 Furthermore, the impact of VDD on other outcome factors such as length of hospitalization and prognosis remains uncertain. 12 More research is thus warranted to formulate concrete recommendations regarding VDD and Covid-19.To guide further research, an assessment of the research conducted so far is essential. It helps in identifying the research gaps and the hotspots that the researchers need to focus on further. Such an assessment of previous research on any topic is often achieved through bibliometric studies. 13,14 The bibliometric studies also help identify major research contributors such as leading authors, organizations, and countries that facilitate more meaningful collaborations. 15 The previous bibliometric studies on Covid-19 did not evaluate the effects of VDD separately. 16,17 Furthermore, the mapping studies on worldwide research on vitamin D were conducted prior to the Covid-19 pandemic. [18][19][20] Thus, there is no bibliometric

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Section: Discussionmentioning

confidence: 99%

Covid-19 and Vitamin D Deficiency: A Scientometric Assessment of Global Publications during 2020-21

Dayal¹,

Gupta²,

Surulinathi³

et al. 2021

JYP

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show abstract

“…In addition, this vitamin has preventive effects against respiratory viral infections." Vaghari-Tabari et al (2021) Respiratory viral infections; Influenza viruses; unregulated immune response; inflammation; tissue damage; antiviral immune response; immune regulation; COVID-19 IIC “Patients with sepsis have a high mortality rate as well as a high prevalence of vitamin D deficiency. In addition, septic patients have decreased vitamin D binding protein levels which further exacerbates vitamin D deficiency.…”

Section: Appendix 2cf Linkage Mechanisms and Biomarkersmentioning

confidence: 99%

Modifiable contributing factors to COVID-19: A comprehensive review

Kostoff

Briggs²,

Kanduc

et al. 2023

Food and Chemical Toxicology

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“…(5) Moreover, the various nutritional structures in different countries may lead to the generation of heterogeneity and the instability of results. (6) The selection of cases may also affect the conclusions, as shown by the heterogeneity test, respectively. More nutritional structure-controlled studies were needed to confirm the conclusion of the present meta-analysis.…”

Section: Limitationsmentioning

confidence: 99%

“…Neonates with younger gestational age tend to suffer from a higher incidence rate, lighter weight, and a higher fatality rate (3). Vitamin D is a fat-soluble steroid derivative that plays very important physiological functions in the human body (4), namely improving the body's absorption of calcium and phosphorus, promoting growth and bone calcification (5), and regulating the body's immune function (6). With more and more in-depth research at home and abroad in recent years, many animal and laboratory studies have found that the lack of vitamin D is also involved in the occurrence of respiratory diseases in children (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Level and Neonatal Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis

Zang

Zhang

et al. 2022

Front. Pediatr.

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BackgroundIn recent years, vitamin D in the occurrence of lung diseases has gradually become a hot topic. Although the role of vitamin D in normal lung development has been confirmed, the correlation between vitamin D level and neonatal respiratory distress syndrome (NRDS) is not clear.ObjectiveTo evaluate the association between vitamin D level and NRDS.MethodsWe performed a comprehensive search of the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure (CNKI). Literature screening and quality assessment were performed according to inclusion and exclusion criteria. The Newcastle–Ottawa Scale was used to assess the methodological components of each study, and Stata 15.1 software to perform the Meta-analysis.ResultsA total of nine case-control studies were included, with 653 infants with NRDS and 501 infants without NRDS. The Meta-analysis showed no heterogeneity across all studies(I2=0.0%, P=0.583). The fixed-effect model showed that 25 hydroxy vitamin D level of children in the NRDS group was significantly lower than that of the non-NRDS group(SMD = −0.51, 95%CI: −0.63 to −0.39, p ≤ 0.05).ConclusionThis systematic review and meta-analysis study suggests that vitamin D deficiency is very likely to be a high-risk factor of NRDS, and reasonable vitamin D supplementation during pregnancy and after birth is of great significance.

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Vitamin D in respiratory viral infections: a key immune modulator?

Cited by 17 publications

References 175 publications

Covid-19 and Vitamin D Deficiency: A Scientometric Assessment of Global Publications during 2020-21

Covid-19 and Vitamin D Deficiency: A Scientometric Assessment of Global Publications during 2020-21

Modifiable contributing factors to COVID-19: A comprehensive review

Association Between Vitamin D Level and Neonatal Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis

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