Vitamin D increases programmed death receptor-1 expression in Crohn’s disease

Bendix, Mia; Greisen, Susanne; Dige, Anders; Hvas, Christian Lodberg; Bak, Nina Friis; Jørgensen, Søren Peter; Dahlerup, Jens Frederik; Deleuran, Bent; Agnholt, Jørgen

doi:10.18632/oncotarget.15489

Cited by 25 publications

(22 citation statements)

References 40 publications

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“…Vitamin D attenuates chronic inflammation related to increased cancer risk [reviewed in (163,164)]. Vitamin D modulates the inflammatory immune response by up-regulation of PD-1, as was observed in Crohn's disease (165) and induces the expression of programmed death-ligand 1 (PD-L1) and PD-L2 via VDR in experimental cell-based models (166). Immune response regulation by vitamin D is linked to the inhibition of type 1 T-helper (Th1) and promotion of Th2 phenotype, including up-regulation of interleukin 10 (IL10) and TGFβ (167,168).…”

Section: Vitamin D and Melanoma: Experimental And Clinical Evidencementioning

confidence: 99%

Relevance of Vitamin D in Melanoma Development, Progression and Therapy

2019

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Melanoma is one of the most lethal types of skin cancer, with a poor prognosis once the disease enters metastasis. The efficacy of currently available treatment schemes for advanced melanomas is low, expensive, and burdened by significant side-effects. Therefore, there is a need to develop new treatment options. Skin cells are able to activate vitamin D via classical and non-classical pathways. Vitamin D derivatives have anticancer properties which promote differentiation and inhibit proliferation. The role of systemic vitamin D in patients with melanoma is unclear as epidemiological studies are not definitive. In contrast, experimental data have clearly shown that vitamin D and its derivatives have anti-melanoma properties. Furthermore, molecular and clinicopathological studies have demonstrated a correlation between defects in vitamin D signaling and progression of melanoma and disease outcome. Therefore, adequate vitamin D signaling can play a role in the treatment of melanoma. Skin cells are able to activate vitamin D via classical and nonclassical metabolic pathways (1-9). Vitamin D derivatives have anticancer properties and promote differentiation and inhibit proliferation of various cells, including melanoma, the most aggressive and lethal type of skin cancer. In this review, we provide an overview on the endogenous synthesis and activation of vitamin D via classical and non-classical pathways. We also present the association of vitamin D and melanoma based on epidemiological, experimental and clinical evidence, showing that defects in vitamin D signaling correlate with progression of melanoma and disease outcome. Therefore, restoration of the adequate vitamin D signaling can play a role in melanoma therapy. 473 This article is freely accessible online.

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Section: Vitamin D and Melanoma: Experimental And Clinical Evidencementioning

confidence: 99%

Relevance of Vitamin D in Melanoma Development, Progression and Therapy

2019

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“…Calcitriol also impairs the function of interstitial dendritic cells, limiting their ability to activate T cells within the gut [63]. Furthermore, direct signaling via vitamin D receptors on T cells leads to upregulation of programmed death receptors and the downregulation of the activating receptor CD69 [64]. These properties provide a rational physiological means by which vitamin D deficiency affects IBD pathogenesis.…”

Section: Literature Reviewmentioning

confidence: 99%

Micronutrient Absorption and Related Outcomes in People with Inflammatory Bowel Disease: A Review

Kilby

Mathias

Boisvenue³

et al. 2019

Nutrients

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Inflammatory Bowel Disease (IBD) is a chronic disorder associated with immune dysregulation and chronic inflammation of the digestive tract. While it is poorly understood, the role of nutrition and nutrient status in the etiology of IBD and its associated outcomes has led to increased research relating to micronutrient deficiency. This review offers an overview of recent literature related to micronutrient absorption and outcomes in adults with IBD. Although the absorption and IBD-related outcomes of some micronutrients (e.g., vitamin D and iron) are well understood, other micronutrients (e.g., vitamin A) require further research. Increased research and clinician knowledge of the relationship between micronutrients and IBD may manifest in improved nutrient screening, monitoring, treatment, and outcomes for people living with IBD.

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“…In Crohn’s disease patients, vitamin D treatment also increased PD-1 expression in CD4+CD25+int T cells and reduced T cell activation. On the other hand, in vitro treatment with vitamin D reduced PD-1 expression, thus indicating that the response of T cells to vitamin D stimulation may differ depending on the environmental conditions [ 76 ]. In turn, an increase in PD-L1 expression was observed followed by RESV treatment in breast and colorectal cancer cell lines.…”

Section: Discussionmentioning

confidence: 99%

Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191

Maj

Bobak

et al. 2021

IJMS

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Plant polyphenols and vitamins D exhibit chemopreventive and therapeutic anticancer effects. We first evaluated the biological effects of the plant polyphenol resveratrol (RESV) and vitamin D active metabolite PRI-2191 on lung cancer cells having different genetic backgrounds. RESV and PRI-2191 showed divergent responses depending on the genetic profile of cells. Antiproliferative activity of PRI-2191 was noticeable in EGFRmut cells, while RESV showed the highest antiproliferative and caspase-3-inducing activity in KRASmut cells. RESV upregulated p53 expression in wtp53 cells, while downregulated it in mutp53 cells with simultaneous upregulation of p21 expression in both cases. The effect of PRI-2191 on the induction of CYP24A1 expression was enhanced by RESV in two KRASmut cell lines. The effect of RESV combined with PRI-2191 on cytokine production was pronounced and modulated. RESV cooperated with PRI-2191 in regulating the expression of IL-8 in EGFRmut cells, while OPN in KRASmut cells and PD-L1 in both cell subtypes. We hypothesize that the differences in response to RESV and PRI-2191 between EGFRmut and KRASmut cell lines result from the differences in epigenetic modifications since both cell subtypes are associated with the divergent smoking history that can induce epigenetic alterations.

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Vitamin D increases programmed death receptor-1 expression in Crohn’s disease

Cited by 25 publications

References 40 publications

Relevance of Vitamin D in Melanoma Development, Progression and Therapy

Relevance of Vitamin D in Melanoma Development, Progression and Therapy

Micronutrient Absorption and Related Outcomes in People with Inflammatory Bowel Disease: A Review

Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191

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