Vitamin D insufficiency and deficiency in pediatric renal transplant recipients

Ebbert, Kirsten; Chow, Josephine; Krempien, Jennifer; Matsuda‐Abedini, Mina; Dionne, Janis M.

doi:10.1111/petr.12527

Cited by 10 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Little research has compared the 25(OH)D serum levels between patients undergoing KT and the healthy population. Our findings coincide with those of Ebbert et al, who analyzed a pediatric population, reporting the presence of hypo D in patients undergoing KT as well as control groups 15. However, our findings showed that patients undergoing KT had a higher prevalence of deficiency.…”

Section: Discussionsupporting

confidence: 92%

Hypovitaminosis D in patients undergoing kidney transplant: the importance of sunlight exposure

Vilarta¹,

Unger²,

Reis³

et al. 2017

Clinics

View full text Add to dashboard Cite

OBJECTIVES:Recent studies have shown a high prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D level less than 30 ng/ml, in both healthy populations and patients with chronic kidney disease. Patients undergoing kidney transplant are at an increased risk of skin cancer and are advised to avoid sunlight exposure. Therefore, these patients might share two major risk factors for hypovitaminosis D: chronic kidney disease and low sunlight exposure. This paper describes the prevalence and clinical characteristics of hypovitaminosis D among patients undergoing kidney transplant.METHODS:We evaluated 25-hydroxyvitamin D serum levels in a representative sample of patients undergoing kidney transplant. We sought to determine the prevalence of hypovitaminosis D, compare these patients with a control group, and identify factors associated with hypovitaminosis D (e.g., sunlight exposure and dietary habits).RESULTS:Hypovitaminosis D was found in 79% of patients undergoing kidney transplant, and the major associated factor was low sunlight exposure. These patients had higher creatinine and intact parathyroid hormone serum levels, with 25-hydroxyvitamin D being inversely correlated with intact parathyroid hormone serum levels. Compared with the control group, patients undergoing kidney transplant presented a higher prevalence of 25-hydroxyvitamin D deficiency and lower serum calcium, phosphate and albumin but higher creatinine and intact parathyroid hormone levels.CONCLUSIONS:Our results confirmed the high prevalence of hypovitaminosis D in patients undergoing kidney transplant. Therapeutic strategies such as moderate sunlight exposure and vitamin D supplementation should be seriously considered for this population.

show abstract

Section: Discussionsupporting

confidence: 92%

Hypovitaminosis D in patients undergoing kidney transplant: the importance of sunlight exposure

Vilarta¹,

Unger²,

Reis³

et al. 2017

Clinics

View full text Add to dashboard Cite

show abstract

“…Abnormalities in mineral metabolism including disturbances in serum calcium, phosphorus, parathyroid hormone (PTH), and vitamin D stores, are common in children following kidney transplant and increase the risk for growth delay and osteopenia or rickets. [40][41][42] Determinants of growth following transplant include age at the time of transplant, exposure to glucocorticoids, allograft function, and administration of recombinant human growth hormone (rhGH). Children under the age of 6 years have increased growth rates following transplant compared to older children.…”

Section: Growth and Development Short Stature And Bone Healthmentioning

confidence: 99%

Long-Term Outcomes of Kidney Transplantation in Children

Winterberg

Garro

2019

Pediatric Clinics of North America

View full text Add to dashboard Cite

“…The 25(OH)D levels were low before and after transplantation in this study with no apparent association with FGF23 or αKlotho. It was reported that 25(OH)D deficiency was also present in pediatric CKD patients, 36 and pediatric kidney transplant patients, 37 which was associated with graft function. 38 The present results are consistent with this, but the association with graft function is unclear.…”

Section: Discussionmentioning

confidence: 99%

Fibroblast growth factor 23‐Klotho and mineral metabolism in the first year after pediatric kidney transplantation: A single‐center prospective study

Kubota

Hamasaki

Hashimoto

et al. 2022

Pediatric Transplantation

View full text Add to dashboard Cite

Background:The role of fibroblast growth factor 23 (FGF23) levels in mineral metabolism before and after kidney transplantation in pediatric patients is poorly understood. Methods:We prospectively evaluated 24 patients under 18 years of age (4.5 [3.3-9.8] years) who underwent living kidney transplantation between July 2016 and March 2018, and measured intact FGF23 and serum αKlotho levels, and other parameters of mineral metabolism before and after transplantation (Day 7, 1 and 4 months, and 1 year). Relationships between parameters were examined by linear analysis.Results: FGF23 level was 440.8 [63.4-5916.3] pg/ml pre-transplant and decreased significantly to 37.1 [16.0-71.5] pg/ml at Day 7 post-transplant (−91.6%, p < .001).Thereafter, it remained at normal levels until 1 year. αKlotho level was 785 [568-1292] pg/ml pre-transplant and remained low at Day 7 and 1 month post-transplant, with an increasing trend at 4 months. Post-transplant phosphorus levels were significantly decreased compared with pre-transplant, with a lowest level of 1.7 [1.3-2.9] mg/dl, −5.7 [−6.8, −3.8] SD at Day 4, followed by gradual recovery. Phosphorus levels and the ratio of tubular maximum phosphate reabsorption were significantly and negatively associated with pre-transplant FGF23 until 4 months of post-transplant.Pre-transplant αKlotho was negatively associated with pre-transplant FGF23 but not FGF23 or other parameters after transplantation. Conclusion: FGF23 in pediatric kidney transplant patients decreased rapidly after transplantation and associated with post-transplant hypophosphatemia and increased phosphorus excretion. Post-transplant αKlotho was low early post-transplant but tended to increase subsequently. Post-transplant αKlotho was unaffected by pretransplant FGF23 or other factors, suggesting pre-transplant chronic kidney disease status has no effect.

show abstract

Vitamin D insufficiency and deficiency in pediatric renal transplant recipients

Cited by 10 publications

References 26 publications

Hypovitaminosis D in patients undergoing kidney transplant: the importance of sunlight exposure

Hypovitaminosis D in patients undergoing kidney transplant: the importance of sunlight exposure

Long-Term Outcomes of Kidney Transplantation in Children

Fibroblast growth factor 23‐Klotho and mineral metabolism in the first year after pediatric kidney transplantation: A single‐center prospective study

Contact Info

Product

Resources

About