Vitamin D Insufficiency/Deficiency Management

Kuriacose, Reena; Olive, Kenneth E.

doi:10.1097/smj.0000000000000051

Cited by 12 publications

(11 citation statements)

References 1 publication

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“…Our study identifies the incidence of vitamin D insufficiency in terms of serum 25(OH)D <75 nmol/L (<30 ng/mL) and deficiency <50 nmol/L (<20 ng/mL) [13, 14]. This study shows that 63.3% of the patients had vitamin D deficiency and 100% had insufficiency, while, among the controls, 50% had insufficiency and 0% had deficiency.…”

Section: Discussionmentioning

confidence: 99%

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

et al. 2016

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Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma. Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects. Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that. Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.

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Section: Discussionmentioning

confidence: 99%

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

et al. 2016

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“…We demonstrate for the first time that VD biosynthesis and/or metabolism is compromised in BRCA1 mut carriers. While BRCA wt women had a normal VD status (44.1 ng/ml on average), BRCA1 mut carriers exhibited VD-insufficiency (29.4 ng/ml on average) according to the clinical definition (20-29.9 ng/ml serum calcifediol) [25], despite a lack of data on UV light exposure and diet supplementation. Ineffective conversion of skin-derived and dietary cholecalciferol into calcifediol in the liver may result from previously reported BRCA1 mutrelated liver dysfunction [36].…”

Section: Discussionmentioning

confidence: 99%

“…Although ages were comparable between BRCA1 mut carriers and BRCA wt patients (36.1 ± 1.7 versus 37.1 ± 1.4 years; p = 0.33), BRCA1 mut carriers had ~33% lower (p = 0.003) serum calcifediol concentrations than those of BRCA wt patients (29.4 ± 2.3 versus 44.1 ± 4.0 ng/ml). Serum calcifediol level of 20-29.9 ng/ml is defined as VD insufficiency [25]. While ~92% (12 of 13) of BRCA wt patients had healthy levels of VD (> 30 ng/ml serum calcifediol), 54% (6 of 11) of BRCA1 mut carriers exhibited VD insufficiency (21.7-27.7 ng/ml serum calcifediol) ( Table 2).…”

Section: Reduced Serum Vd Levels In Healthy Women With Brca1 Mutmentioning

confidence: 99%

Association between vitamin D and ovarian cancer development in BRCA1 mutation carriers

et al. 2020

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“…Atualmente, a deficiência de vitamina D é considerada uma epidemia, e a suplementação desta vitamina tem sido cada vez mais recomendada 39 . A suplementação com micronutrientes pode ajudar a evitar o desenvolvimento de doenças, contudo sua ingestão excessiva, principalmente das vitaminas lipossolúveis, pode trazer consequências à saúde, causando diversos problemas, como danos hepáticos, descamação na pele, enxaqueca e vômito 40 .…”

Section: Riscos à Saúdeunclassified

Suplementos vitamínicos e/ou minerais: regulamentação, consumo e implicações à saúde

2015

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Em decorrência das mudanças no padrão alimentar da população, a suplementação da dieta com micronutrientes é prática comum. A preocupação com a saúde e a facilidade de comercialização dos suplementos vitamínicos e/ou minerais, aliadas ao forte apelo publicitário, têm estimulado a população ao consumo indiscriminado desses produtos, o que pode acarretar riscos à saúde. Este trabalho teve como objetivo avaliar a legislação relativa ao cenário do consumo e segurança do uso de suplementos vitamínicos e/ou minerais no Brasil. Verificou-se que as legislações brasileiras a esse respeito são complexas, dificultando o entendimento das normas e a aplicação destas. Estudos sobre o consumo de suplementos pela população brasileira são limitados, e o consumo inadequado por falta de conhecimento é um potencial risco à saúde da população. Concluiu-se que há necessidade de implementação de políticas públicas que promovam o esclarecimento da população, dos profissionais da área de saúde e do comércio sobre o assunto.

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Vitamin D Insufficiency/Deficiency Management

Cited by 12 publications

References 1 publication

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

Association between vitamin D and ovarian cancer development in BRCA1 mutation carriers

Suplementos vitamínicos e/ou minerais: regulamentação, consumo e implicações à saúde

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