Vitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults

Cardoso-Sánchez, Laura Ivonne; Gómez-Díaz, Rita A.; Wacher, Niels H.

doi:10.1016/j.nutres.2015.05.019

Cited by 9 publications

(8 citation statements)

References 63 publications

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“…Therefore, vitamin D might have enhanced glucose utilization in the present participants. Vitamin D is thought to improve insulin sensitivity, insulin secretion and lipid metabolism; however, the present data from the serum analyses did not show such improvements. In contrast, the ΔRQ correlated with the average glycated hemoglobin level during the observation period in patients receiving alfacalcidol and those with increased 25[OH]D levels (Figure d).…”

Section: Discussioncontrasting

confidence: 97%

Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6‐month follow‐up evaluation

Ogata

Iwasaki

Ide

et al. 2017

J of Diabetes Invest

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Aims/IntroductionResting energy expenditure was associated with a serum bone turnover marker in postmenopausal women with type 2 diabetes (T2DMPW) in the present cross‐sectional study. To clarify the fundamental pathological factor for the correlation of bone metabolism and basal metabolism in type 2 diabetes, a 6‐month prospective follow‐up study was carried out with supplementation of vitamin D.Materials and MethodsA total of 44 T2DMPW were enrolled. The following factors were evaluated at the beginning and the end of the summer: procollagen type 1 N‐terminal propeptide, carboxy‐terminal collagen crosslinks‐1, intact parathyroid hormone and 25‐hydroxyvitamin D (25[OH]D), as well as diabetic complications, body composition, respiratory quotient and resting energy expenditure. A total of 23 patients with low 25(OH)D levels (˂20 ng/mL) were instructed to increase vitamin D levels by lifestyle change. Among them, 15 patients with osteoporosis were also administered alfacalcidol.ResultsSerum 25(OH)D increased in 25 patients and decreased in 19 patients. Patients who did not receive the study intervention at the start tended to have a decreased 2525(OH)D level; therefore, the average 25(OH)D level of all patients was not changed. Changes in resting energy expenditure were positively correlated with those of procollagen type 1 N‐terminal propeptide/carboxy‐terminal collagen crosslinks‐1. Changes in the respiratory quotient correlated with the mean glycated hemoglobin levels; procollagen type 1 N‐terminal propeptide levels positively correlated with serum 25(OH)D after the intervention. These correlations were prominent in patients with increased 25(OH)D and those with alfacalcidol supplementation.ConclusionsRestoration of vitamin D level might be a prerequisite for a normal correlation between bone and basal metabolism in T2DMPW. Lifestyle intervention for retention of vitamin D level is important even in summer, in T2DMPW.

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Section: Discussioncontrasting

confidence: 97%

Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6‐month follow‐up evaluation

Ogata

Iwasaki

Ide

et al. 2017

J of Diabetes Invest

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“…Our study is the first to report on the relationship between serum VD levels and IR parameters in adult patients with T1DM. In a previous study, Cardoso-Sanchez et al did not report a significant association between VD levels and IR in a population with adultonset latent autoimmune diabetes (LADA) [38]. However, the study group of Cardoso-Sanchez et al with LADA was relatively small (n = 33).…”

Section: Discussionmentioning

confidence: 93%

Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration

Kamińśki

Uruska

Rogowicz-Frontczak

et al. 2019

Exp Clin Endocrinol Diabetes

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Aim Type 1 diabetes mellitus (T1DM) is a disease characterized by an absolute deficiency of endogenous insulin secretion. Insulin resistance (IR) may develop among patients with T1DM. Vitamin D deficiency was reported to be a risk factor in the development of IR. The aim of the study was to assess the relationship between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and IR among patients with T1DM. Methods The test group consisted of 110 adult patients [males=65 (59%)] with T1DM. Participants were recruited in Poland between 1st October and 30th April in 2015/2016 and 2016/2017. VD serum level was assessed by ELISA array. IR was assessed by estimated Glucose Disposal Rate (eGDR). Results In the study group 21 (19%) patients were recognized as IR according to eGDR cut-offs (<7.5 mg/kg/min), 52 (47.3%) patients had VD deficiency (25(OH)D<20 ng/ml), 16 (14.5%) patients had 25(OH)D<10 ng/ml. Only 6 (5%) participants reported VD supplementation. Patients with IR, according to eGDR cut-off revealed significantly lower 25(OH)D serum level 15.7 (9.2–28.4) vs. 22.1 (13.0–38.4) ng/ml; p=0.04 as compared to patients without IR. R Spearman analysis found a positive relationship between VD and eGDR (Rs=0.27; p<0.01). Logistic regression analysis revealed significant relationship between the presence of IR and VD serum level/presence of 25(OH)D serum level below 10 ng/ml, both models adjusted to sex, age, BMI, LDL and triglycerides, accordingly (OR=0.95, CI: 0.90–0.99; p=0.04) and (OR=4.19, CI: 1.04–16.93; p=0.04). Conclusion The serum concentration of Vitamin D is negatively associated with insulin resistance in patients with T1DM and may have clinical implications.

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“…First, misclassification might exist in the type of T2DM as it has been shown that approximately 10% of typical T2DM of all ages is accounted for by latent autoimmune diabetes [32], for which we are not able to exclude from our analysis. Although the exact impact of this issue is unknown, it is possible that the association between vitamin D status and T2DM has been underestimated as it has been observed that vitamin D intake was associated with insulin resistance in patients with T2DM but not latent autoimmune diabetes [33]. Second, the 25OHD levels were analysed from serum samples that had been collected in 1980 and stored for 30 years in À20 C, which may be inaccurate and erroneously low.…”

Section: Discussionmentioning

confidence: 99%

Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study

Juonala

Pitkänen

et al. 2017

Annals of Medicine

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High serum 25OHD levels in youth, and from child to adult life, were associated with a reduced risk of developing T2DM in adulthood. Key Messages High serum 25OHD levels in youth, and between youth and adulthood, were associated with a lower risk of T2DM in adulthood. Each SD (15.2 nmol/L) increment in youth serum 25OHD levels was associated with a 26% reduction in odds for T2DM, which was independent of a number of confounding variables and other risk factors for T2DM. A similar magnitude of association was observed for the long-term 25OHD levels between youth and adulthood. These findings suggest a potentially simple and cost-effective strategy for reducing adulthood risk of T2DM starting in an earlier stage of life - improving and maintaining vitamin D status throughout youth and early adulthood.

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Vitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults

Cited by 9 publications

References 63 publications

Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6‐month follow‐up evaluation

Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6‐month follow‐up evaluation

Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration

Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study

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