Vitamin D is Not a Protective Factor in <scp>ALS</scp>

Blasco, Hélène; Hounoum, Blandine Madji; Dufour‐Rainfray, Diane; Patin, Franck; Maillot, F.; Beltran, S.; Gordon, Paul H.; Andres, Christian R.; Corcia, Philippe

doi:10.1111/cns.12423

Cited by 29 publications

(33 citation statements)

References 43 publications

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“…Moreover, vitamin D applied on motoneurons cultured in vitro seems to potentiate the effects of glial-and brainderived neurotrophic growth factors, protecting cells from Fas-induced cell death (Camu et al, 2014). Although ev- idence from the animal models suggests an effect of supplemental vitamin D on ALS, these positive results may not always extend to humans (Minshull et al, 2016;Blasco et al, 2015;Yang et al, 2016). Similarly to our results, studies in healthy subjects indicated that vitamin D intake did not improve muscle tropism and strength (Agergaard et al, 2015).…”

Section: Discussionsupporting

confidence: 75%

“…Camu et al (2014 found an association between low vitamin D levels and a shorter survival time in patients with ALS, even after excluding non-ambulatory patients with vitamin D deficiency, probably due to severely decreased physical activity (Camu et al, 2014). Other studies revealed that high vitamin D levels correlate with a worse prognosis in ALS patients (Blasco et al, 2015). The discrepancy between these data and ours might be because ALS patients can not perform adequate physical activity, and despite the vitamin D supplementation, they do not get those benefits observed in physically active patients (Al-Eisa et al, 2016;Agergaard et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…A recent study has proposed vitamin D supplementation as a potential treatment option to delay ALS progression (Karam et al, 2013). Different data have been published on an association between lower vitamin D levels and a faster rate of decline with shorter survival (Camu et al, 2014;Blasco et al, 2015). But the literature contains contradictory results on the association of vitamin D levels with clinical progression of ALS.…”

Section: Introductionmentioning

confidence: 99%

“…But the literature contains contradictory results on the association of vitamin D levels with clinical progression of ALS. In some studies, levels of vitamin D are associated with a better prognosis, in others with a worse prognosis (Karam et al, 2013;Camu et al, 2014;Blasco et al, 2015). Recent studies hypothesized a negative effect of vitamin D deficit on the structure and function of the neuromuscular junction, causing lack of a stress response in muscles (Gifondorwa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D in amyotrophic lateral sclerosis

Libonati¹,

Onesti²,

Gori³

et al. 2017

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SummaryVitamin D supplementation has been proposed as a potential treatment to delay amyotrophic lateral sclerosis (ALS) progression. The aims of this study were to compare retrospectively vitamin D blood levels in ALS patients with those in healthy subjects; to correlate vitamin D blood levels with clinical functions in patients; and to evaluate whether administration of vitamin D could modify the clinical progression of the disease. Vitamin D blood levels were evaluated in 57 ALS patients and in 57 healthy subjects. In the ALS patients the following clinical variables were evaluated every 3 months: Medical Research Council scale (MRC) score; revised ALS functional rating scale (ALSFRS-R) score; forced vital capacity (FVC). Twentyfour patients were treated with high doses of cholecalciferol. No significant differences were found between the vitamin D blood levels in the ALS patients (18.8 ± 12.2) and the healthy subjects (20.7 ± 10.1). The vitamin D levels in the ALS patientsdid not correlate with recorded clinical parameters. No clinical differences in terms of ALSFRS-R, MRC or FVC were found between the treated and the untreated patients over time. In ALS, as in other chronic neurological diseases, levels of vitamin D in blood appeared reduced, but no difference was found between the levels in ALS patients and in healthy subjects. Oral vitamin D supplementation in ALS patients was not associated with better prognosis in comparison with untreated ALS patients. Further prospective controlled studies are needed to clarify the effect of vitamin D on the progression of ALS disease.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D in amyotrophic lateral sclerosis

Libonati¹,

Onesti²,

Gori³

et al. 2017

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“…But as discussed by the authors, potential limitations of this study are its retrospective character and the sample size [131]. Two earlier studies also described an absent relationship between serum 25(OH)D 3 levels and prognosis in ALS [132,133]. A very recent study examined the outcome of supplementation of 50,000, 75,000, and 100,000 IU vitamin D 3 /month on motor dysfunction and clinical progression of ALS.…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 93%

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Lauer¹,

Janitschke²,

Hartmann³

et al. 2020

Vitamin D Deficiency

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Approximately 90% of the elderly population in the western countries has at least a mild to moderate vitamin D hypovitaminosis. Besides the well-known function of vitamin D in calcium homeostasis, it has been recently found that several enzymes and receptors involved in its homeostasis are expressed in the nervous system and brain suggesting also an important role in the brain homeostasis. Interestingly, epidemiological and clinical studies found reduced vitamin D level associated with an increased risk of several neurodegenerative disorders. In this chapter, we focus on a potential link between vitamin D and Alzheimer's disease, Parkinson's disease, multiple sclerosis, prion disease, and motor neuron disease. Epidemiological studies were summarized, an overview of the known potential underlying pathomolecular mechanisms are given, and results from clinical studies dealing with vitamin D supplementation were presented. As an outlook, recent literature suggesting an impact of vitamin D on autism spectrum disease, depression, and schizophrenia are briefly discussed. In conclusion, the identification of an abundant vitamin D metabolism in the brain and the tight link between the increasing number of several neurological and mental disorders emphasize the need of further research making a clear recommendation of the intake and supplementation of vitamin D in a growing elderly population.

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Association of 25‐hydroxyvitamin D status with brain volume changes

Lee

Yoon

Kim

et al. 2021

Food Science & Nutrition

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Vitamin D is known to be critical to brain function and has neuroprotective effects (Anjum et al., 2018). Low levels of blood vitamin D accelerate cognitive impairment, and it especially results in executive dysfunction and episodic memory impairment (Miller et al., 2015). This is known to happen through regulating the release of neurotrophic factors, increasing antioxidant capacity, and decreasing the production of inflammation markers (Eyles et al., 2005;Grant, 2009;Moore et al., 2005). The high density of vitamin D receptors (VDR) in the hippocampus, hypothalamus, thalamus, cortex, and substantia nigra suggests the potential of vitamin D to influence neurological conditions (Fleet, 2004). Vitamin D contributes to neuronal development by regulating the synthesis of nerve growth factor (NGF) and various neurotransmitters such as acetylcholine (Ach), dopamine (DA), and gamma-aminobutyric acid (GABA)

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Vitamin D is Not a Protective Factor in ALS

Cited by 29 publications

References 43 publications

Vitamin D in amyotrophic lateral sclerosis

Vitamin D in amyotrophic lateral sclerosis

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Association of 25‐hydroxyvitamin D status with brain volume changes

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