Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case–control study

Einisman, Helly; Reyes, María Loreto; Angulo, Jenniffer; Cerda, Jaime; López-Lastra, Marcelo; Castro-Rodriguez, José A.

doi:10.1111/pai.12409

Cited by 28 publications

(30 citation statements)

References 27 publications

(36 reference statements)

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“…Overall, no significant differences were found in Apal (rs7975232) and Taql (rs731236) in relationship to vitamin D levels, however a possible association was found between vitamin D sufficiency and Fokl C allele. 40 A more recent study has made attempts to shed more light into this subject. A meta-analysis was conducted the determine the relationship between childhood asthma and VDR gene polymorphisms, Apal (rs7975232), Bsml (rs1544410), Fokl (rs2228570) and Taql (rs731236).…”

Section: Childrenmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

101

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Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations and overall worse outcomes in patients with asthma. Given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Several studies have found that low serum levels of vitamin D (< 20 ng/ml) are associated with increased exacerbations, increased airway inflammation, decreased lung function and poor prognosis in asthmatic patients. Results from the in vitro and in vivo studies in animals and human have suggested that supplementation with vitamin D can ameliorate several hallmark features of asthma. However, the findings obtained from clinical trials are controversial and do not unequivocally support the beneficial role of vitamin D in asthma. Largely, interventional studies in children, pregnant women and adults have primarily found little-to-no effect of vitamin D supplementation on improved asthma symptoms, onset or progression of the disease. This could be related to the severity of the disease process and other confounding factors. Despite the conflicting data obtained from clinical trials, vitamin D deficiency does influence the inflammatory response in the airways. Further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce anti-inflammatory effects. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in bronchial asthma.

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Section: Childrenmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

101

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“…The significant differences between the FokI C allele and vitamin D insufficiency were found. Moreover, no dissimilarities between both ApaI, TaqI and the levels of vitamin D were shown [17].…”

Section: Childrenmentioning

confidence: 94%

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Szymczak

Pawliczak

2018

Advances in Respiratory Medicine

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Asthma -a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients. Thus, it provides positive relation between vitamin D and asthma. Increased prevalence of asthma over the past decades causes elevated interest in vitamin D supplementation that is even reported as a ,,potential therapeutic option''. Unfortunately, results of clinical trials are inconsistent and do not provide supportive information about positive role of vitamin D in asthma. Little or even no effect of supplementation of vitamin D in improvement of onset, symptoms or progression of asthma was found in comprehensive interventional studies in adults, children and pregnant woman. This review critically summarized the last years evidence of a relation between vitamin D and asthma in adults, children and pregnant women.

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“…47 Asma y DVD: Varios estudios han asociado la DVD con la gravedad del asma. Einisman et al, 48 no encontraron diferencias entre las concentraciones de 25(OH)D de niños saludables y asmáticos; sin embargo, dentro del grupo de niños asmáticos, encontraron diferencia en las concentraciones de suficiencia de 25(OH) D, que fue mayor en los niños que estaban en fase 4 de tratamiento de asma según la Global Initiative for Asthma (GINA) y, en este mismo grupo, encontraron que el alelo C del Fok I del receptor de VD estaba presente en todos los niños a diferencia de los otros niños con asma. Un metaanálisis reciente evaluó estudios del suplemento de VD (las dosis usadas fueron de 500 y 1200 UI de VD3 al día) y mostró una reducción significativa en el riesgo de exacerbación de asma (RR= 0,28; IC 95%: 0,12-0,64).…”

Section: Asmaunclassified

Deficiencia de vitamina D en la práctica clínica pediátrica

2018

Arch Argent Pediatr

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Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case–control study

Abstract: We found a possible association of vitamin D sufficiency status and FokI C allele with higher requirement of therapy to reach asthma control, suggesting that it may be involved in treatment response. Variations in VDR might also play a role in the 25OHD levels.

Cited by 28 publications

References 27 publications

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Deficiencia de vitamina D en la práctica clínica pediátrica

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